The Molecular Mechanism of Action of Artemisinin—The Debate Continues

por O’Neill, Paul M., Barton, Victoria E., Ward, Stephen A.
Publicado 2010

Synthesis of MeBmt and related derivatives via syn-selective ATH-DKR

por Rolt, Adam, O'Neill, Paul M., Liang, T. Jake, Stachulski, Andrew V.
Publicado 2019

Unprecedented Convergent Synthesis of Sugar-Functionalization of Phosphinic Acids under Metal-Free Conditions

por Abdou, Moaz M., O’Neill, Paul M., Amigues, Eric, Matziari, Magdalini
Publicado 2022

Study of the antimalarial activity of 4-aminoquinoline compounds against chloroquine-sensitive and chloroquine-resistant parasite strains

por Lawrenson, Alexandre S., Cooper, David L., O’Neill, Paul M., Berry, Neil G.
Publicado 2018

Recent Advances of DprE1 Inhibitors against Mycobacterium tuberculosis: Computational Analysis of Physicochemical and ADMET Properties

por Amado, Patrícia S. M., Woodley, Christopher, Cristiano, Maria L. S., O’Neill, Paul M.
Publicado 2022

Antimalarial Agents as Therapeutic Tools Against Toxoplasmosis—A Short Bridge between Two Distant Illnesses

por Secrieru, Alina, Costa, Inês C. C., O’Neill, Paul M., Cristiano, Maria L. S.
Publicado 2020

Design, Synthesis, and Study of a Novel RXPA380–Proline Hybrid (RXPA380-P) as an Antihypertensive Agent

por Abdou, Moaz M., Dong, Dewen, O’Neill, Paul M., Amigues, Eric, Matziari, Magdalini
Publicado 2022

Novel Selenium-based compounds with therapeutic potential for SOD1-linked amyotrophic lateral sclerosis

por Amporndanai, Kangsa, Rogers, Michael, Watanabe, Seiji, Yamanaka, Koji, O'Neill, Paul M., Hasnain, S. Samar
Publicado 2020

Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential

por Antoine, Thomas, Fisher, Nicholas, Amewu, Richard, O'Neill, Paul M., Ward, Stephen A., Biagini, Giancarlo A.
Publicado 2014

Control and regulation of S‐Adenosylmethionine biosynthesis by the regulatory β subunit and quinolone‐based compounds

por Panmanee, Jiraporn, Bradley‐Clarke, Jack, Mato, Jose M., O'Neill, Paul M., Antonyuk, Svetlana V., Hasnain, S. Samar
Publicado 2019

A Click Chemistry‐Based Proteomic Approach Reveals that 1,2,4‐Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile

por Ismail, Hanafy M., Barton, Victoria E., Panchana, Matthew, Charoensutthivarakul, Sitthivut, Biagini, Giancarlo A., Ward, Stephen A., O'Neill, Paul M.
Publicado 2016

A Click Chemistry‐Based Proteomic Approach Reveals that 1,2,4‐Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile

por Ismail, Hanafy M., Barton, Victoria E., Panchana, Matthew, Charoensutthivarakul, Sitthivut, Biagini, Giancarlo A., Ward, Stephen A., O'Neill, Paul M.
Publicado 2016

Antimalarial pharmacology and therapeutics of atovaquone

por Nixon, Gemma L., Moss, Darren M., Shone, Alison E., Lalloo, David G., Fisher, Nicholas, O'Neill, Paul M., Ward, Stephen A., Biagini, Giancarlo A.
Publicado 2013

X-ray and cryo-EM structures of inhibitor-bound cytochrome bc (1) complexes for structure-based drug discovery

por Amporndanai, Kangsa, Johnson, Rachel M., O’Neill, Paul M., Fishwick, Colin W. G., Jamson, Alexander H., Rawson, Shaun, Muench, Stephen P., Hasnain, S. Samar, Antonyuk, Svetlana V.
Publicado 2018

Ebselen as template for stabilization of A4V mutant dimer for motor neuron disease therapy

por Chantadul, Varunya, Wright, Gareth S. A., Amporndanai, Kangsa, Shahid, Munazza, Antonyuk, Svetlana V., Washbourn, Gina, Rogers, Michael, Roberts, Natalie, Pye, Matthew, O’Neill, Paul M., Hasnain, S. Samar
Publicado 2020

Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications

por Walsh, Joanne, Jenkins, Rosalind E., Wong, Michael, Olayanju, Adedamola, Powell, Helen, Copple, Ian, O’Neill, Paul M., Goldring, Christopher E.P., Kitteringham, Neil R., Park, B. Kevin
Publicado 2014

Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives

por Amporndanai, Kangsa, Meng, Xiaoli, Shang, Weijuan, Jin, Zhenmig, Rogers, Michael, Zhao, Yao, Rao, Zihe, Liu, Zhi-Jie, Yang, Haitao, Zhang, Leike, O’Neill, Paul M., Samar Hasnain, S.
Publicado 2021

The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation

por Capper, Michael J., Wright, Gareth S. A., Barbieri, Letizia, Luchinat, Enrico, Mercatelli, Eleonora, McAlary, Luke, Yerbury, Justin J., O’Neill, Paul M., Antonyuk, Svetlana V., Banci, Lucia, Hasnain, S. Samar
Publicado 2018

α-Methyl-α-phenylsuccinimide ameliorates neurodegeneration in a C. elegans model of TDP-43 proteinopathy

por Wong, Shi Quan, Pontifex, Matthew G., Phelan, Marie M., Pidathala, Chandra, Kraemer, Brian C., Barclay, Jeff W., Berry, Neil G., O'Neill, Paul M., Burgoyne, Robert D., Morgan, Alan
Publicado 2018

The Molecular Basis of Folate Salvage in Plasmodium falciparum: CHARACTERIZATION OF TWO FOLATE TRANSPORTERS

por Salcedo-Sora, J. Enrique, Ochong, Edwin, Beveridge, Susan, Johnson, David, Nzila, Alexis, Biagini, Giancarlo A., Stocks, Paul A., O'Neill, Paul M., Krishna, Sanjeev, Bray, Patrick G., Ward, Stephen A.
Publicado 2011