A thorough QTc study demonstrates that olmesartan medoxomil does not prolong the QTc interval

por Mendell, Jeanne, Matsushima, Nobuko, O'Reilly, Terry E., Lee, James
Publicado 2015

2389. Effect of Rezafungin on QT Interval in Healthy Subjects

por Flanagan, Shawn, Goodman, Daniel B, Rao, Pallavi, Jandourek, Alena, O’Reilly, Terry, Sandison, Taylor
Publicado 2018

SAT-430 A Phase 1 Study in Healthy Volunteers to Assess the Safety, Tolerability, and Pharmacokinetics of ONO-5788: A Novel Oral Small Molecule Somatostatin Receptor Type-2 Agonist

por Kaviya, Arpeat, O'Reilly, Terry, Batonga, Joelle, Seki, Akiteru, Beale, Dominic, Yoneda, Kazuhiro, Bruce, Mark
Publicado 2019

First‐in‐Human Study of AG10, a Novel, Oral, Specific, Selective, and Potent Transthyretin Stabilizer for the Treatment of Transthyretin Amyloidosis: A Phase 1 Safety, Tolerability...

por Fox, Jonathan C., Hellawell, Jennifer L., Rao, Satish, O'Reilly, Terry, Lumpkin, Rick, Jernelius, Jesper, Gretler, Daniel, Sinha, Uma
Publicado 2019

Safety, Tolerability, Pharmacokinetics, and Concentration-QTc Analysis of Tetrodotoxin: A Randomized, Dose Escalation Study in Healthy Adults

por Kavoosi, Mojgan, O’Reilly, Terry E., Kavoosi, Mehran, Chai, Peng, Engel, Caroline, Korz, Walter, Gallen, Christopher C., Lester, Robert M.
Publicado 2020

Pharmacokinetics and Macrophage Inhibitory Cytokine‐1 Pharmacodynamics of the Murine Double Minute 2 Inhibitor, Navtemadlin (KRT‐232) in Fed and Fasted Healthy Subjects

por Wong, Shekman, Krejsa, Cecile, Lee, Dana, Harris, Anna, Simard, Emilie, Wang, Xiaohui, Allard, Martine, Podoll, Terry, O'Reilly, Terry, Slatter, J. Greg
Publicado 2022

Inhibition of fatty acid synthase with FT‐4101 safely reduces hepatic de novo lipogenesis and steatosis in obese subjects with non‐alcoholic fatty liver disease: Results from two e...

por Beysen, Carine, Schroeder, Patricia, Wu, Eric, Brevard, Julie, Ribadeneira, Maria, Lu, Wei, Dole, Kiran, O'Reilly, Terry, Morrow, Linda, Hompesch, Marcus, Hellerstein, Marc K., Li, Kelvin, Johansson, Lars, Kelly, Patrick F.
Publicado 2020

A large multicentre, randomized, double‐blind, cross‐over study in healthy volunteers to compare pharmacokinetics, pharmacodynamics and safety of a pegfilgrastim biosimilar with it...

por Bellon, Anne, Wang, Jessie, Skerjanec, Andrej, Velinova, Maria, Dickerson, Daniel, Sabet, Ahad, Ngo, Ly, O'Reilly, Terry, Tomek, Charles, Schussler, Steven, Schier‐Mumzhiu, Stefanie, Gattu, Sreekanth, Koch, Sven D., Schelcher, Celine, Dobreva, Miryana, Boldea, Anca, Nakov, Roumen, Otto, Gordon P.
Publicado 2020

Safety and immunogenicity of intramuscular, single-dose V590 (rVSV-SARS-CoV-2 Vaccine) in healthy adults: Results from a phase 1 randomised, double-blind, placebo-controlled, dose-...

por Robbins, Jonathan A., Tait, Dereck, Huang, Qinlei, Dubey, Sheri, Crumley, Tami, Cote, Josee, Luk, Julie, Sachs, Jeffrey R., Rutkowski, Kathryn, Park, Harriet, Schwab, Robert, Howitt, William Joseph, Rondon, Juan Carlos, Hernandez-Illas, Martha, O'Reilly, Terry, Smith, William, Simon, Jakub, Hardalo, Cathy, Zhao, Xuemei, Wnek, Richard, Cope, Alethea, Lai, Eseng, Annunziato, Paula, Guris, Dalya, Stoch, S. Aubrey
Publicado 2022