Cathepsin B Dipeptidyl Carboxypeptidase and Endopeptidase Activities Demonstrated across a Broad pH Range

por Yoon, Michael C., Hook, Vivian, O’Donoghue, Anthony J.
Publicado 2022

Distinct Cleavage Properties of Cathepsin B Compared to Cysteine Cathepsins Enable the Design and Validation of a Specific Substrate for Cathepsin B over a Broad pH Range

por Yoon, Michael C., Phan, Von, Podvin, Sonia, Mosier, Charles, O’Donoghue, Anthony J., Hook, Vivian
Publicado 2023

Giant magnetoresistive biosensors for real-time quantitative detection of protease activity

por Adem, Sandeep, Jain, Sonal, Sveiven, Michael, Zhou, Xiahan, O’Donoghue, Anthony J., Hall, Drew A.
Publicado 2020

Validation of Babesia proteasome as a drug target

por Jalovecka, Marie, Hartmann, David, Miyamoto, Yukiko, Eckmann, Lars, Hajdusek, Ondrej, O'Donoghue, Anthony J., Sojka, Daniel
Publicado 2018

Discovery of New Inhibitors of Hepatitis C Virus NS3/4A Protease and Its D168A Mutant

por Meewan, Ittipat, Zhang, Xingquan, Roy, Suchismita, Ballatore, Carlo, O’Donoghue, Anthony J., Schooley, Robert T., Abagyan, Ruben
Publicado 2019

Distinct Dibasic Cleavage Specificities of Neuropeptide-Producing Cathepsin L and Cathepsin V Cysteine Proteases Compared to PC1/3 and PC2 Serine Proteases

por Yoon, Michael C., Ames, Janneca, Mosier, Charles, Jiang, Zhenze, Podvin, Sonia, O’Donoghue, Anthony J., Hook, Vivian
Publicado 2022

Differential Neuropeptidomes of Dense Core Secretory Vesicles (DCSV) Produced at Intravesicular and Extracellular pH Conditions by Proteolytic Processing

por Jiang, Zhenze, Lietz, Christopher B., Podvin, Sonia, Yoon, Michael C., Toneff, Thomas, Hook, Vivian, O’Donoghue, Anthony J.
Publicado 2021

Activity profiling of peptidases in Angiostrongylus costaricensis first-stage larvae and adult worms

por Rebello, Karina M., McKerrow, James H., Mota, Ester M., O´Donoghue, Anthony J., Neves-Ferreira, Ana Gisele C.
Publicado 2018

A dual-binding magnetic immunoassay to predict spontaneous preterm birth

por Sveiven, Michael, Gassman, Andrew, Rosenberg, Joshua, Chan, Matthew, Boniface, Jay, O’Donoghue, Anthony J., Laurent, Louise C., Hall, Drew A.
Publicado 2023

Cysteine and Aspartyl Proteases Contribute to Protein Digestion in the Gut of Freshwater Planaria

por Goupil, Louise S., Ivry, Sam L., Hsieh, Ivy, Suzuki, Brian M., Craik, Charles S., O’Donoghue, Anthony J., McKerrow, James H.
Publicado 2016

Discovery of pH-Selective Marine and Plant Natural Product Inhibitors of Cathepsin B Revealed by Screening at Acidic and Neutral pH Conditions

por Phan, Von V., Mosier, Charles, Yoon, Michael C., Glukhov, Evgenia, Caffrey, Conor R., O’Donoghue, Anthony J., Gerwick, William H., Hook, Vivian
Publicado 2022

Global Substrate Profiling of Proteases in Human Neutrophil Extracellular Traps Reveals Consensus Motif Predominantly Contributed by Elastase

por O’Donoghue, Anthony J., Jin, Ye, Knudsen, Giselle M., Perera, Natascha C., Jenne, Dieter E., Murphy, John E., Craik, Charles S., Hermiston, Terry W.
Publicado 2013

Isoforms of Cathepsin B1 in Neurotropic Schistosomula of Trichobilharzia regenti Differ in Substrate Preferences and a Highly Expressed Catalytically Inactive Paralog Binds Cystati...

por Dvořáková, Hana, Leontovyč, Roman, Macháček, Tomáš, O'Donoghue, Anthony J., Šedo, Ondřej, Zdráhal, Zbyněk, Craik, Charles S., Caffrey, Conor R., Horák, Petr, Mikeš, Libor
Publicado 2020

Structural elucidation of recombinant Trichomonas vaginalis 20S proteasome bound to covalent inhibitors

por Silhan, Jan, Fajtova, Pavla, Bartosova, Jitka, Hurysz, Brianna M., Almaliti, Jehad, Miyamoto, Yukiko, Eckmann, Lars, Gerwick, William H., O’Donoghue, Anthony J., Boura, Evzen
Publicado 2023

A Dual‐Color Fluorescent Probe Allows Simultaneous Imaging of Main and Papain‐like Proteases of SARS‐CoV‐2‐Infected Cells for Accurate Detection and Rapid Inhibitor Screening...

por Cheng, Yong, Borum, Raina M., Clark, Alex E., Jin, Zhicheng, Moore, Colman, Fajtová, Pavla, O'Donoghue, Anthony J., Carlin, Aaron F., Jokerst, Jesse V.
Publicado 2022

Integrated Activity and Genetic Profiling of Secreted Peptidases in Cryptococcus neoformans Reveals an Aspartyl Peptidase Required for Low pH Survival and Virulence

por Clarke, Starlynn C., Dumesic, Phillip A., Homer, Christina M., O’Donoghue, Anthony J., La Greca, Florencia, Pallova, Lenka, Majer, Pavel, Madhani, Hiten D., Craik, Charles S.
Publicado 2016

The Pseudomonas aeruginosa protease LasB directly activates IL-1β

por Sun, Josh, LaRock, Doris L., Skowronski, Elaine A., Kimmey, Jacqueline M., Olson, Joshua, Jiang, Zhenze, O'Donoghue, Anthony J., Nizet, Victor, LaRock, Christopher N.
Publicado 2020

Insights into the catalytic properties of the mitochondrial rhomboid protease PARL

por Lysyk, Laine, Brassard, Raelynn, Arutyunova, Elena, Siebert, Verena, Jiang, Zhenze, Takyi, Emmanuella, Morrison, Melissa, Young, Howard S., Lemberg, Marius K., O’Donoghue, Anthony J., Lemieux, M. Joanne
Publicado 2021

A Parasite Cysteine Protease Is Key to Host Protein Degradation and Iron Acquisition

por O'Brien, Theresa C., Mackey, Zachary B., Fetter, Richard D., Choe, Youngchool, O'Donoghue, Anthony J., Zhou, Min, Craik, Charles S., Caffrey, Conor R., McKerrow, James H.
Publicado 2008

Molecular characterization and functional analysis of the Schistosoma mekongi Ca(2+)-dependent cysteine protease (calpain)

por Chaimon, Salisa, Limpanont, Yanin, Reamtong, Onrapak, Ampawong, Sumate, Phuphisut, Orawan, Chusongsang, Phiraphol, Ruangsittichai, Jiraporn, Boonyuen, Usa, Watthanakulpanich, Dorn, O’Donoghue, Anthony J., Caffrey, Conor R., Adisakwattana, Poom
Publicado 2019