Citius, Altius, Fortius: Performance in a Bottle for CAR T-Cells

por Ayari, Asma, O’Connor, Roddy S.
Publicado 2020

Beyond the Lactate Paradox: How Lactate and Acidity Impact T Cell Therapies against Cancer

por Tu, Violet Y., Ayari, Asma, O’Connor, Roddy S.
Publicado 2021

Humanized Chimeric Antigen Receptor (CAR) T cells

por Kozani, Pouya Safarzadeh, Kozani, Pooria Safarzadeh, O’Connor, Roddy S.
Publicado 2021

Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47-mediated ‘don’t eat me signal’.

por Liu, Mingen, O’Connor, Roddy S., Trefely, Sophie, Graham, Kathleen, Snyder, Nathaniel W., Beatty, Gregory L
Publicado 2019

F-actin polymerization and retrograde flow drive sustained PLCγ1 signaling during T cell activation

por Babich, Alexander, Li, Shuixing, O'Connor, Roddy S., Milone, Michael C., Freedman, Bruce D., Burkhardt, Janis K.
Publicado 2012

Recent Metabolic Advances for Preventing and Treating Acute and Chronic Graft Versus Host Disease

por Mohamed, Fathima A., Thangavelu, Govindarajan, Rhee, Stephanie Y., Sage, Peter T., O’Connor, Roddy S., Rathmell, Jeffrey C., Blazar, Bruce R.
Publicado 2021

Enhancing CAR T function with the engineered secretion of C. perfringens neuraminidase

por Durgin, Joseph S., Thokala, Radhika, Johnson, Lexus, Song, Edward, Leferovich, John, Bhoj, Vijay, Ghassemi, Saba, Milone, Michael, Binder, Zev, O'Rourke, Donald M., O'Connor, Roddy S.
Publicado 2022

Quantification of lactoyl-CoA (lactyl-CoA) by liquid chromatography mass spectrometry in mammalian cells and tissues

por Varner, Erika L., Trefely, Sophie, Bartee, David, von Krusenstiern, Eliana, Izzo, Luke, Bekeova, Carmen, O'Connor, Roddy S., Seifert, Erin L., Wellen, Kathryn E., Meier, Jordan L., Snyder, Nathaniel W.
Publicado 2020

CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy

por Rodriguez-Garcia, Alba, Lynn, Rachel C., Poussin, Mathilde, Eiva, Monika A., Shaw, Lauren C., O’Connor, Roddy S., Minutolo, Nicholas G., Casado-Medrano, Victoria, Lopez, Gonzalo, Matsuyama, Takami, Powell, Daniel J.
Publicado 2021

The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations

por O’Connor, Roddy S., Guo, Lili, Ghassemi, Saba, Snyder, Nathaniel W., Worth, Andrew J., Weng, Liwei, Kam, Yoonseok, Philipson, Benjamin, Trefely, Sophie, Nunez-Cruz, Selene, Blair, Ian A., June, Carl H., Milone, Michael C.
Publicado 2018

Sequential Exposure to IL21 and IL15 During Human Natural Killer Cell Expansion Optimizes Yield and Function

por Zhang, Caimei, Kadu, Siddhant, Xiao, Yansen, Johnson, Omar, Kelly, Andre, O'Connor, Roddy S., Lai, Meizan, Kong, Hong, Srivatsa, Sriram, Tai, Victoria, Greenblatt, Eli, Holmes, Matthew, Riley, James L., June, Carl H., Sheppard, Neil C.
Publicado 2023

CAR T-Cells Depend on the Coupling of NADH Oxidation with ATP Production

por Garcia-Canaveras, Juan C., Heo, David, Trefely, Sophie, Leferovich, John, Xu, Chong, Philipson, Benjamin I., Ghassemi, Saba, Milone, Michael C., Moon, Edmund K., Snyder, Nathaniel W., June, Carl H., Rabinowitz, Joshua D., O’Connor, Roddy S.
Publicado 2021

Enhancing Chimeric Antigen Receptor T Cell Anti-tumor Function through Advanced Media Design

por Ghassemi, Saba, Martinez-Becerra, Francisco J., Master, Alyssa M., Richman, Sarah A., Heo, David, Leferovich, John, Tu, Yitao, García-Cañaveras, Juan Carlos, Ayari, Asma, Lu, Yinan, Wang, Ai, Rabinowitz, Joshua D., Milone, Michael C., June, Carl H., O’Connor, Roddy S.
Publicado 2020

Case Report: Prolonged Survival Following EGFRvIII CAR T Cell Treatment for Recurrent Glioblastoma

por Durgin, Joseph S., Henderson, Fraser, Nasrallah, MacLean P., Mohan, Suyash, Wang, Sumei, Lacey, Simon F., Melenhorst, Jan Joseph, Desai, Arati S., Lee, John Y. K., Maus, Marcela V., June, Carl H., Brem, Steven, O’Connor, Roddy S., Binder, Zev, O’Rourke, Donald M.
Publicado 2021

Rapid manufacturing of non-activated potent CAR T cells

por Ghassemi, Saba, Durgin, Joseph S., Nunez-Cruz, Selene, Patel, Jai, Leferovich, John, Pinzone, Marilia, Shen, Feng, Cummins, Katherine D., Plesa, Gabriela, Cantu, Vito Adrian, Reddy, Shantan, Bushman, Frederic D., Gill, Saar I., O’Doherty, Una, O’Connor, Roddy S., Milone, Michael C.
Publicado 2022

Targeting PARP11 to avert immunosuppression and improve CAR T therapy in solid tumors

por Zhang, Hongru, Yu, Pengfei, Tomar, Vivek S., Chen, Xiangjie, Atherton, Matthew J., Lu, Zhen, Zhang, Hong-Guang, Li, Shifeng, Ortiz, Angelica, Gui, Jun, Leu, N. Adrian, Yan, Fangxue, Blanco, Andres, Meyer-Ficca, Mirella L., Meyer, Ralph G., Beiting, Daniel P., Li, Jinyang, Nunez-Cruz, Selene, O’Connor, Roddy S., Johnson, Lexus R., Minn, Andy J., George, Subin S., Koumenis, Constantinos, Diehl, J. Alan, Milone, Michael C., Zheng, Hui, Fuchs, Serge Y.
Publicado 2022