LRRK2 and α-Synuclein: Distinct or Synergistic Players in Parkinson’s Disease?

por O’Hara, Darren M., Pawar, Grishma, Kalia, Suneil K., Kalia, Lorraine V.
Publicado 2020

Dichloroacetate Stabilizes Mitochondrial Fusion Dynamics in Models of Neurodegeneration

por O’Hara, Darren, Davis, Gavin M., Adlesic, Natalie A., Hayes, Jerrard M., Davey, Gavin P.
Publicado 2019

BAG5 Promotes Alpha-Synuclein Oligomer Formation and Functionally Interacts With the Autophagy Adaptor Protein p62

por Friesen, Erik L., Zhang, Yu Tong, Earnshaw, Rebecca, De Snoo, Mitch L., O’Hara, Darren M., Agapova, Victoria, Chau, Hien, Ngana, Sophie, Chen, Kevin S., Kalia, Lorraine V., Kalia, Suneil K.
Publicado 2020

Early-onset impairment of the ubiquitin-proteasome system in dopaminergic neurons caused by α-synuclein

por McKinnon, Chris, De Snoo, Mitchell L., Gondard, Elise, Neudorfer, Clemens, Chau, Hien, Ngana, Sophie G., O’Hara, Darren M., Brotchie, Jonathan M., Koprich, James B., Lozano, Andres M., Kalia, Lorraine V., Kalia, Suneil K.
Publicado 2020

Bcl-2-associated athanogene 5 (BAG5) regulates Parkin-dependent mitophagy and cell death

por De Snoo, Mitchell L., Friesen, Erik L., Zhang, Yu Tong, Earnshaw, Rebecca, Dorval, Geneviève, Kapadia, Minesh, O’Hara, Darren M., Agapova, Victoria, Chau, Hien, Pellerito, Ornella, Tang, Matthew Y., Wang, Xinzhu, Schmitt-Ulms, Gerold, Durcan, Thomas M., Fon, Edward A., Kalia, Lorraine V., Kalia, Suneil K.
Publicado 2019

Disrupting the α-synuclein-ESCRT interaction with a peptide inhibitor mitigates neurodegeneration in preclinical models of Parkinson’s disease

por Nim, Satra, O’Hara, Darren M., Corbi-Verge, Carles, Perez-Riba, Albert, Fujisawa, Kazuko, Kapadia, Minesh, Chau, Hien, Albanese, Federica, Pawar, Grishma, De Snoo, Mitchell L., Ngana, Sophie G., Kim, Jisun, El-Agnaf, Omar M. A., Rennella, Enrico, Kay, Lewis E., Kalia, Suneil K., Kalia, Lorraine V., Kim, Philip M.
Publicado 2023

Small molecule inhibitors of α-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in C. elegans

por Chen, Kevin S., Menezes, Krystal, Rodgers, Jarlath B., O’Hara, Darren M., Tran, Nhat, Fujisawa, Kazuko, Ishikura, Seiya, Khodaei, Shahin, Chau, Hien, Cranston, Anna, Kapadia, Minesh, Pawar, Grishma, Ping, Susan, Krizus, Aldis, Lacoste, Alix, Spangler, Scott, Visanji, Naomi P., Marras, Connie, Majbour, Nour K., El-Agnaf, Omar M. A., Lozano, Andres M., Culotti, Joseph, Suo, Satoshi, Ryu, William S., Kalia, Suneil K., Kalia, Lorraine V.
Publicado 2021