Human FcRn Tissue Expression Profile and Half-Life in PBMCs

por Fan, Yao-Yun, Farrokhi, Vahid, Caiazzo, Teresa, Wang, Mengmeng, O’Hara, Denise M., Neubert, Hendrik
Publicado 2019

Physiologically relevant binding affinity quantification of monoclonal antibody PF‐00547659 to mucosal addressin cell adhesion molecule for in vitro in vivo correlation

por Wang, Mengmeng, Kussrow, Amanda K, Ocana, Mireia Fernandez, Chabot, Jeffrey R, Lepsy, Christopher S, Bornhop, Darryl J, O'Hara, Denise M
Publicado 2016

Changes in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor (FcRn) and pharmacokinetics

por Piche-Nicholas, Nicole M., Avery, Lindsay B., King, Amy C., Kavosi, Mania, Wang, Mengmeng, O'Hara, Denise M., Tchistiakova, Lioudmila, Katragadda, Madan
Publicado 2017

Understanding Lung Deposition of Alpha-1 Antitrypsin in Acute Experimental Mouse Lung Injury Model Using Fluorescence Microscopy

por Wang, Mengmeng, Zhan, Yutian, Chen, Jianqing, Rong, Haojing, O'Neil, Shawn P., Ghosh, Brahma, Nguyen, Vuong, Owens, Jane, Li, Xianfeng, O'Hara, Denise M.
Publicado 2016

Glyco-engineered Long Acting FGF21 Variant with Optimal Pharmaceutical and Pharmacokinetic Properties to Enable Weekly to Twice Monthly Subcutaneous Dosing

por Weng, Yan, Ishino, Tetsuya, Sievers, Annette, Talukdar, Saswata, Chabot, Jeffrey R., Tam, Amy, Duan, Weili, Kerns, Kelvin, Sousa, Eric, He, Tao, Logan, Alison, Lee, Darwin, Li, Dongmei, Zhou, Yingjiang, Bernardo, Barbara, Joyce, Alison, Kavosi, Mania, O’Hara, Denise M., Clark, Tracey, Guo, Jie, Giragossian, Craig, Stahl, Mark, Calle, Roberto A., Kriz, Ron, Somers, Will, Lin, Laura
Publicado 2018