Optimizing Treatment Options for Newly Diagnosed Acute Myeloid Leukemia in Older Patients with Comorbidities

por Oshikawa, Gaku, Sasaki, Koji
Publicado 2023

DNA Damage Stress and Inhibition of Jak2-V617F Cause Its Degradation and Synergistically Induce Apoptosis through Activation of GSK3β

por Nagao, Toshikage, Oshikawa, Gaku, Wu, Nan, Kurosu, Tetsuya, Miura, Osamu
Publicado 2011

PECAM-1 is involved in BCR/ABL signaling and may downregulate imatinib-induced apoptosis of Philadelphia chromosome-positive leukemia cells

por WU, NAN, KUROSU, TETSUYA, OSHIKAWA, GAKU, NAGAO, TOSHIKAGE, MIURA, OSAMU
Publicado 2012

Inhibition of the PI3K/Akt/GSK3 Pathway Downstream of BCR/ABL, Jak2-V617F, or FLT3-ITD Downregulates DNA Damage-Induced Chk1 Activation as Well as G2/M Arrest and Prominently Enhan...

por Kurosu, Tetsuya, Nagao, Toshikage, Wu, Nan, Oshikawa, Gaku, Miura, Osamu
Publicado 2013

Acute promyelocytic leukemia presenting as recurrent spinal myeloid sarcomas 3 years before developing leukemia: A case report with review of literature

por Yamashita, Tomoko, Nishijima, Akihiko, Noguchi, Yuma, Narukawa, Kensuke, Oshikawa, Gaku, Takano, Hina
Publicado 2019

Acute myeloid leukemia with t(3;21)(q26.2;q22) developing following low-dose methotrexate therapy for rheumatoid arthritis and expressing two AML1/MDS1/EVI1 fusion proteins: A case...

por Tanaka, Keisuke, Oshikawa, Gaku, Akiyama, Hiroki, Ishida, Shinya, Nagao, Toshikage, Yamamoto, Masahide, Miura, Osamu
Publicado 2017

Proliferation and Survival Signaling from Both Jak2-V617F and Lyn Involving GSK3 and mTOR/p70S6K/4EBP1 in PVTL-1 Cell Line Newly Established from Acute Myeloid Leukemia Transformed...

por Nagao, Toshikage, Kurosu, Tetsuya, Umezawa, Yoshihiro, Nogami, Ayako, Oshikawa, Gaku, Tohda, Shuji, Yamamoto, Masahide, Miura, Osamu
Publicado 2014

FLT3-ITD confers resistance to the PI3K/Akt pathway inhibitors by protecting the mTOR/4EBP1/Mcl-1 pathway through STAT5 activation in acute myeloid leukemia

por Nogami, Ayako, Oshikawa, Gaku, Okada, Keigo, Fukutake, Shusaku, Umezawa, Yoshihiro, Nagao, Toshikage, Kurosu, Tetsuya, Miura, Osamu
Publicado 2015

Mechanisms for mTORC1 activation and synergistic induction of apoptosis by ruxolitinib and BH3 mimetics or autophagy inhibitors in JAK2-V617F-expressing leukemic cells including ne...

por Ishida, Shinya, Akiyama, Hiroki, Umezawa, Yoshihiro, Okada, Keigo, Nogami, Ayako, Oshikawa, Gaku, Nagao, Toshikage, Miura, Osamu
Publicado 2018

P777: EFFICACY AND SAFETY OF ROMIPLOSTIM COMBINED WITH CYCLOSPORINE A AS A FIRST-LINE TREATMENT IN PATIENTS WITH APLASTIC ANEMIA: A PHASE 2/3 CLINICAL TRIAL.

por Chiba, Shigeru, Wook Lee, Jong, Ho Jang, Jun, Yoon, Sung-Soo, Oshikawa, Gaku, Usuki, Kensuke, Mun, Yeung-Chul, Kawakita, Toshiro, Imada, Kazunori, Cheong, June-Won, Noshiro, Masayoshi, Matsuda, Akira, Ozawa, Keiya, Mitani, Kinuko, Kanda, Yoshinobu, Nakao, Shinji
Publicado 2023

Importance of TKI treatment duration in treatment-free remission of chronic myeloid leukemia: results of the D-FREE study

por Yoshida, Chikashi, Yamaguchi, Hiroki, Doki, Noriko, Murai, Kazunori, Iino, Masaki, Hatta, Yoshihiro, Onizuka, Makoto, Yokose, Norio, Fujimaki, Katsumichi, Hagihara, Masao, Oshikawa, Gaku, Murayama, Kayoko, Kumagai, Takashi, Kimura, Shinya, Najima, Yuho, Iriyama, Noriyoshi, Tsutsumi, Ikuyo, Oba, Koji, Kojima, Hiroshi, Sakamaki, Hisashi, Inokuchi, Koiti
Publicado 2023