Rapid Synthesis and Screening of Chemically Activated Transcription Factors with GFP-based Reporters

por McIsaac, R. Scott, Oakes, Benjamin L., Botstein, David, Noyes, Marcus B.
Publicado 2013

Deep sequencing of large library selections allows computational discovery of diverse sets of zinc fingers that bind common targets

por Persikov, Anton V., Rowland, Elizabeth F., Oakes, Benjamin L., Singh, Mona, Noyes, Marcus B.
Publicado 2014

Synthetic gene expression perturbation systems with rapid, tunable, single-gene specificity in yeast

por McIsaac, R. Scott, Oakes, Benjamin L., Wang, Xin, Dummit, Krysta A., Botstein, David, Noyes, Marcus B.
Publicado 2013

Programmable RNA recognition and cleavage by CRISPR/Cas9

por O’Connell, Mitchell R., Oakes, Benjamin L., Sternberg, Samuel H., East-Seletsky, Alexandra, Kaplan, Matias, Doudna, Jennifer A.
Publicado 2014

Profiling of engineering hotspots identifies an allosteric CRISPR-Cas9 switch

por Oakes, Benjamin L, Nadler, Dana C., Flamholz, Avi, Fellmann, Christof, Staahl, Brett T., Doudna, Jennifer A., Savage, David F.
Publicado 2016

A systematic survey of the Cys(2)His(2) zinc finger DNA-binding landscape

por Persikov, Anton V., Wetzel, Joshua L., Rowland, Elizabeth F., Oakes, Benjamin L., Xu, Denise J., Singh, Mona, Noyes, Marcus B.
Publicado 2015

Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors

por Huang, Tony P., Zhao, Kevin T., Miller, Shannon M., Gaudelli, Nicole M., Oakes, Benjamin L., Fellmann, Christof, Savage, David F., Liu, David R.
Publicado 2019

Multi-reporter selection for the design of active and more specific zinc-finger nucleases for genome editing

por Oakes, Benjamin L., Xia, Danny F., Rowland, Elizabeth F., Xu, Denise J., Ankoudinova, Irina, Borchardt, Jennifer S., Zhang, Lei, Li, Patrick, Miller, Jeffrey C., Rebar, Edward J., Noyes, Marcus B.
Publicado 2016

Comprehensive deletion landscape of CRISPR-Cas9 identifies minimal RNA-guided DNA-binding modules

por Shams, Arik, Higgins, Sean A., Fellmann, Christof, Laughlin, Thomas G., Oakes, Benjamin L., Lew, Rachel, Kim, Shin, Lukarska, Maria, Arnold, Madeline, Staahl, Brett T., Doudna, Jennifer A., Savage, David F.
Publicado 2021

Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs

por Kundert, Kale, Lucas, James E., Watters, Kyle E., Fellmann, Christof, Ng, Andrew H., Heineike, Benjamin M., Fitzsimmons, Christina M., Oakes, Benjamin L., Qu, Jiuxin, Prasad, Neha, Rosenberg, Oren S., Savage, David F., El-Samad, Hana, Doudna, Jennifer A., Kortemme, Tanja
Publicado 2019

CRISPR-CasX is an RNA-dominated enzyme active for human genome editing

por Liu, Jun-Jie, Orlova, Natalia, Oakes, Benjamin L., Ma, Enbo, Spinner, Hannah B., Baney, Katherine L.M., Chuck, Jonathan, Tan, Dan, Knott, Gavin J., Harrington, Lucas B., Al-Shayeb, Basem, Wagner, Alexander, Brötzmann, Julian, Staahl, Brett T., Talyor, Kian L., Desmarais, John, Nogales, Eva, Doudna, Jennifer A.
Publicado 2019

The impact of tumor epithelial and microenvironmental heterogeneity on treatment responses in HER2(+) breast cancer

por Janiszewska, Michalina, Stein, Shayna, Metzger Filho, Otto, Eng, Jennifer, Kingston, Natalie L., Harper, Nicholas W., Rye, Inga H., Alečković, Maša, Trinh, Anne, Murphy, Katherine C., Marangoni, Elisabetta, Cristea, Simona, Oakes, Benjamin, Winer, Eric P., Krop, Ian E., Russnes, Hege G., Spellman, Paul T., Bucher, Elmar, Hu, Zhi, Chin, Koei, Gray, Joe W., Michor, Franziska, Polyak, Kornelia
Publicado 2021