Prediction of Metabolite‐to‐Parent Drug Exposure: Derivation and Application of a Mechanistic Static Model

por Callegari, Ernesto, Varma, Manthena V.S., Obach, R. Scott
Publicado 2020

Mini‐Review: Comprehensive Drug Disposition Knowledge Generated in the Modern Human Radiolabeled ADME Study

por Spracklin, Douglas K., Chen, Danny, Bergman, Arthur J., Callegari, Ernesto, Obach, R. Scott
Publicado 2020

Structure-Guided In Vitro to In Vivo Pharmacokinetic Optimization of Propargyl-Linked Antifolates

por Lombardo, M.N., G-Dayanandan, N., Keshipeddy, S., Zhou, W., Si, D., Reeve, S.M., Alverson, J., Barney, P., Walker, L., Hoody, J., Priestley, N.D., Obach, R.S., Wright, D.L.
Publicado 2019

Late-Stage Microsomal Oxidation Reduces Drug–Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189

por Stepan, Antonia F., Tran, Tuan P., Helal, Christopher J., Brown, Maria S., Chang, Cheng, O’Connor, Rebecca E., De Vivo, Michael, Doran, Shawn D., Fisher, Ethan L., Jenkinson, Stephen, Karanian, David, Kormos, Bethany L., Sharma, Raman, Walker, Gregory S., Wright, Ann S., Yang, Edward X., Brodney, Michael A., Wager, Travis T., Verhoest, Patrick R., Obach, R. Scott
Publicado 2018

Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19

por Boras, Britton, Jones, Rhys M., Anson, Brandon J., Arenson, Dan, Aschenbrenner, Lisa, Bakowski, Malina A., Beutler, Nathan, Binder, Joseph, Chen, Emily, Eng, Heather, Hammond, Holly, Hammond, Jennifer, Haupt, Robert E., Hoffman, Robert, Kadar, Eugene P., Kania, Rob, Kimoto, Emi, Kirkpatrick, Melanie G., Lanyon, Lorraine, Lendy, Emma K., Lillis, Jonathan R., Logue, James, Luthra, Suman A., Ma, Chunlong, Mason, Stephen W., McGrath, Marisa E., Noell, Stephen, Obach, R. Scott, O’ Brien, Matthew N., O’Connor, Rebecca, Ogilvie, Kevin, Owen, Dafydd, Pettersson, Martin, Reese, Matthew R., Rogers, Thomas F., Rosales, Romel, Rossulek, Michelle I., Sathish, Jean G., Shirai, Norimitsu, Steppan, Claire, Ticehurst, Martyn, Updyke, Lawrence W., Weston, Stuart, Zhu, Yuao, White, Kris M., García-Sastre, Adolfo, Wang, Jun, Chatterjee, Arnab K., Mesecar, Andrew D., Frieman, Matthew B., Anderson, Annaliesa S., Allerton, Charlotte
Publicado 2021