Transcriptional Regulation of Sphingosine Kinase 1

por Bonica, Joseph, Mao, Cungui, Obeid, Lina M., Hannun, Yusuf A.
Publicado 2020

Inhibition of Caspases Inhibits the Release of Apoptotic Bodies: Bcl-2 Inhibits the Initiation of Formation of Apoptotic Bodies in Chemotherapeutic Agent-induced Apoptosis

por Zhang, Jiandi, Reedy, Mary C., Hannun, Yusuf A., Obeid, Lina M.
Publicado 1999

Inhibition of Sphingosine Kinase-2 in a Murine Model of Lupus Nephritis

por Snider, Ashley J., Ruiz, Phillip, Obeid, Lina M., Oates, Jim C.
Publicado 2013

CHK1 regulates NF-κB signaling upon DNA damage in p53- deficient cells and associated tumor-derived microvesicles

por Carroll, Brittany L., Pulkoski-Gross, Michael J., Hannun, Yusuf A., Obeid, Lina M.
Publicado 2016

AKT as a key target for growth promoting functions of neutral ceramidase in colon cancer cells

por Coant, Nicolas, García-Barros, Mónica, Zhang, Qifeng, Obeid, Lina M., Hannun, Yusuf A.
Publicado 2018

Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response

por Xu, Ruijuan, Wang, Kai, Mileva, Izolda, Hannun, Yusuf A., Obeid, Lina M., Mao, Cungui
Publicado 2016

A role for caspase‐2 in sphingosine kinase 1 proteolysis in response to doxorubicin in breast cancer cells – implications for the CHK1‐suppressed pathway

por Carroll, Brittany L., Bonica, Joseph, Shamseddine, Achraf A., Hannun, Yusuf A., Obeid, Lina M.
Publicado 2017

Alkaline ceramidase catalyzes the hydrolysis of ceramides via a catalytic mechanism shared by Zn(2+)-dependent amidases

por Yi, Jae Kyo, Xu, Ruijuan, Obeid, Lina M., Hannun, Yusuf A., Airola, Michael V., Mao, Cungui
Publicado 2022

Co-ordinated activation of classical and novel PKC isoforms is required for PMA-induced mTORC1 activation

por Liu, Mengling, Clarke, Christopher J., Salama, Mohamed F., Choi, Yeon Ja, Obeid, Lina M., Hannun, Yusuf A.
Publicado 2017

Loss of sphingosine kinase 1 increases lung metastases in the MMTV-PyMT mouse model of breast cancer

por Velazquez, Fabiola N., Zhang, Leiqing, Viscardi, Valentina, Trocchia, Carolena, Hannun, Yusuf A., Obeid, Lina M., Snider, Ashley J.
Publicado 2021

Cytokine Response Modifier A (CrmA) Inhibits Ceramide Formation in Response to Tumor Necrosis Factor (TNF)-α: CrmA and Bcl-2 Target Distinct Components in the Apoptotic Pathway

por Dbaibo, Ghassan S., Perry, David K., Gamard, Chris J., Platt, Rheanna, Poirier, Guy G., Obeid, Lina M., Hannun, Yusuf A.
Publicado 1997

Defining a role for sphingosine kinase 1 in p53-dependent tumors

por Heffernan-Stroud, Linda A., Helke, Kristi L., Jenkins, Russell W., De Costa, Anna-Maria, Hannun, Yusuf A., Obeid, Lina M.
Publicado 2011

Molecular Characterization of Rice OsLCB2a1 Gene and Functional Analysis of its Role in Insect Resistance

por Begum, Mahfuj A., Shi, Xiao-Xiao, Tan, Ye, Zhou, Wen-Wu, Hannun, Yusuf, Obeid, Lina, Mao, Cungui, Zhu, Zeng-Rong
Publicado 2016

Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2

por Xu, Ruijuan, Garcia-Barros, Monica, Wen, Sally, Li, Fang, Lin, Chih-Li, Hannun, Yusuf A., Obeid, Lina M., Mao, Cungui
Publicado 2017

Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis

por Ponnusamy, Suriyan, Selvam, Shanmugam Panneer, Mehrotra, Shikhar, Kawamori, Toshihiko, Snider, Ashley J, Obeid, Lina M, Shao, Yuan, Sabbadini, Roger, Ogretmen, Besim
Publicado 2012

Activation of p38 Mitogen-Activated Protein Kinase in Gaucher’s Disease

por Kitatani, Kazuyuki, Wada, Masayuki, Perry, David, Usui, Toshinori, Sun, Ying, Obeid, Lina M., Yaegashi, Nobuo, Grabowski, Gregory A., Hannun, Yusuf A.
Publicado 2015

Accumulation of Long-Chain Glycosphingolipids during Aging Is Prevented by Caloric Restriction

por Hernández-Corbacho, María José, Jenkins, Russell W., Clarke, Christopher J., Hannun, Yusuf A., Obeid, Lina M., Snider, Ashley J., Siskind, Leah J.
Publicado 2011

Targeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides

por Trayssac, Magali, Clarke, Christopher J., Stith, Jeffrey L., Snider, Justin M., Newen, Naomi, Gault, Christopher R., Hannun, Yusuf A., Obeid, Lina M.
Publicado 2021

PKCα is required for Akt-mTORC1 activation in Non-Small Cell Lung Carcinoma (NSCLC) with EGFR mutation

por Salama, Mohamed F., Liu, Mengling, Clarke, Christopher J., Espaillat, Mel Pilar, Haley, John, Jin, Ting, Wang, Daifeng, Obeid, Lina M., Hannun, Yusuf A.
Publicado 2019

Neutral sphingomyelinase 2 regulates inflammatory responses in monocytes/macrophages induced by TNF-α

por Al-Rashed, Fatema, Ahmad, Zunair, Thomas, Reeby, Melhem, Motasem, Snider, Ashley J., Obeid, Lina M., Al-Mulla, Fahd, Hannun, Yusuf A., Ahmad, Rasheed
Publicado 2020