Human Neural Progenitor Transplantation Rescues Behavior and Reduces α‐Synuclein in a Transgenic Model of Dementia with Lewy Bodies

por Goldberg, Natalie R.S., Marsh, Samuel E., Ochaba, Joseph, Shelley, Brandon C., Davtyan, Hayk, Thompson, Leslie M., Steffan, Joan S., Svendsen, Clive N., Blurton‐Jones, Mathew
Publicado 2017

A novel and translational role for autophagy in antisense oligonucleotide trafficking and activity

por Ochaba, Joseph, Powers, Andrew F, Tremble, Kaitlyn A, Greenlee, Sarah, Post, Noah M, Matson, John E, MacLeod, A Robert, Guo, Shuling, Aghajan, Mariam
Publicado 2019

Neural deficits in a mouse model of PACS1 syndrome are corrected with PACS1- or HDAC6-targeting therapy

por Villar-Pazos, Sabrina, Thomas, Laurel, Yang, Yunhan, Chen, Kun, Lyles, Jenea B., Deitch, Bradley J., Ochaba, Joseph, Ling, Karen, Powers, Berit, Gingras, Sebastien, Kordasiewicz, Holly B., Grubisha, Melanie J., Huang, Yanhua H., Thomas, Gary
Publicado 2023

RNA-targeted therapy corrects neuronal deficits in PACS1 syndrome mice

por Villar-Pazos, Sabrina, Thomas, Laurel, Yang, Yunhan, Chen, Kun, Lyles, Jenea B., Deitch, Bradley J., Ochaba, Joseph, Ling, Karen, Powers, Berit, Gingras, Sebastien, Kordasiewicz, Holly B., Grubisha, Melanie J., Huang, Yanhua H., Thomas, Gary
Publicado 2023

IKKβ slows Huntington’s disease progression in R6/1 mice

por Ochaba, Joseph, Fote, Gianna, Kachemov, Marketta, Thein, Soe, Yeung, Sylvia Y., Lau, Alice L., Hernandez, Sarah, Lim, Ryan G., Casale, Malcolm, Neel, Michael J., Monuki, Edwin S., Reidling, Jack, Housman, David E., Thompson, Leslie M., Steffan, Joan S.
Publicado 2019

Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington’s Disease Knock-In Mouse Models

por Franich, Nicholas R., Basso, Manuela, André, Emily A., Ochaba, Joseph, Kumar, Amit, Thein, Soe, Fote, Gianna, Kachemov, Marketta, Lau, Alice L., Yeung, Sylvia Y., Osmand, Alexander, Zeitlin, Scott O., Ratan, Rajiv R., Thompson, Leslie M., Steffan, Joan S.
Publicado 2018

SUMO-2 and PIAS1 Modulate Insoluble Mutant Huntingtin Protein Accumulation

por O’Rourke, Jacqueline Gire, Gareau, Jaclyn R., Ochaba, Joseph, Song, Wan, Raskó, Tamás, Reverter, David, Lee, John, Monteys, Alex Mas, Pallos, Judit, Mee, Lisa, Vashishtha, Malini, Apostol, Barbara L., Nicholson, Thomas Peter, Illes, Katalin, Zhu, Ya-Zhen, Dasso, Mary, Bates, Gillian P., Difiglia, Marian, Davidson, Beverly, Wanker, Erich E., Marsh, J. Lawrence, Lima, Christopher D., Steffan, Joan S., Thompson, Leslie M.
Publicado 2013

Human Neural Stem Cell Transplantation Rescues Functional Deficits in R6/2 and Q140 Huntington's Disease Mice

por Reidling, Jack C., Relaño-Ginés, Aroa, Holley, Sandra M., Ochaba, Joseph, Moore, Cindy, Fury, Brian, Lau, Alice, Tran, Andrew H., Yeung, Sylvia, Salamati, Delaram, Zhu, Chunni, Hatami, Asa, Cepeda, Carlos, Barry, Joshua A., Kamdjou, Talia, King, Alvin, Coleal-Bergum, Dane, Franich, Nicholas R., LaFerla, Frank M., Steffan, Joan S., Blurton-Jones, Mathew, Meshul, Charles K., Bauer, Gerhard, Levine, Michael S., Chesselet, Marie-Francoise, Thompson, Leslie M.
Publicado 2017

PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington’s disease

por Morozko, Eva L., Smith-Geater, Charlene, Monteys, Alejandro Mas, Pradhan, Subrata, Lim, Ryan G., Langfelder, Peter, Kachemov, Marketta, Hill, Austin, Stocksdale, Jennifer T., Cullis, Pieter R., Wu, Jie, Ochaba, Joseph, Miramontes, Ricardo, Chakraborty, Anirban, Hazra, Tapas K., Lau, Alice, St-cyr, Sophie, Orellana, Iliana, Kopan, Lexi, Wang, Keona Q., Yeung, Sylvia, Leavitt, Blair R., Reidling, Jack C., Yang, X. William, Steffan, Joan S., Davidson, Beverly L., Sarkar, Partha S., Thompson, Leslie M.
Publicado 2021