Targeting RIPK1 for the treatment of human diseases

por Degterev, Alexei, Ofengeim, Dimitry, Yuan, Junying
Publicado 2019

Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target

por Mifflin, Lauren, Ofengeim, Dimitry, Yuan, Junying
Publicado 2020

Synergistic effect of a novel autophagy inhibitor and Quizartinib enhances cancer cell death

por Ouchida, Amanda Tomie, Li, Yingbo, Geng, Jiefei, Najafov, Ayaz, Ofengeim, Dimitry, Sun, Xiaoxiao, Yu, Qiang, Yuan, Junying
Publicado 2018

The endogenous inhibitor of Akt, CTMP, is critical to ischemia-induced neuronal death

por Miyawaki, Takahiro, Ofengeim, Dimitry, Noh, Kyung-Min, Latuszek-Barrantes, Adrianna, Hemmings, Brian A., Follenzi, Antonia, Zukin, R. Suzanne
Publicado 2009

Global ischemia induces lysosomal-mediated degradation of mTOR and activation of autophagy in hippocampal neurons destined to die

por Hwang, Jee-Yeon, Gertner, Michael, Pontarelli, Fabrizio, Court-Vazquez, Brenda, Bennett, Michael Vander Laan, Ofengeim, Dimitry, Zukin, Ruth Suzanne
Publicado 2017

Activation of necroptosis in human and experimental cholestasis

por Afonso, Marta B, Rodrigues, Pedro M, Simão, André L, Ofengeim, Dimitry, Carvalho, Tânia, Amaral, Joana D, Gaspar, Maria M, Cortez-Pinto, Helena, Castro, Rui E, Yuan, Junying, Rodrigues, Cecília M P
Publicado 2016

N-terminally cleaved Bcl-x(L) mediates ischemia-induced neuronal death

por Ofengeim, Dimitry, Chen, Yingbei, Miyawaki, Takahiro, Li, Hongmei, Sacchetti, Silvio, Flannery, Richard J., Alavian, Kambiz N., Pontarelli, Fabrizio, Roelofs, Brian A., Hickman, John A., Hardwick, J. Marie, Zukin, R. Suzanne, Jonas, Elizabeth A.
Publicado 2012

RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis

por Zelic, Matija, Pontarelli, Fabrizio, Woodworth, Lisa, Zhu, Cheng, Mahan, Amy, Ren, Yi, LaMorte, Michael, Gruber, Ross, Keane, Aislinn, Loring, Pequita, Guo, Lilu, Xia, Tai-he, Zhang, Boyao, Orning, Pontus, Lien, Egil, Degterev, Alexei, Hammond, Timothy, Ofengeim, Dimitry
Publicado 2021

CSF1R signaling is a regulator of pathogenesis in progressive MS

por Hagan, Nellwyn, Kane, John L., Grover, Deepak, Woodworth, Lisa, Madore, Charlotte, Saleh, Jacqueline, Sancho, Jose, Liu, Jinyu, Li, Yi, Proto, Jonathan, Zelic, Matija, Mahan, Amy, Kothe, Michael, Scholte, Andrew A., Fitzgerald, Maria, Gisevius, Barbara, Haghikia, Aiden, Butovsky, Oleg, Ofengeim, Dimitry
Publicado 2020

Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death

por Xia, Hong-guang, Najafov, Ayaz, Geng, Jiefei, Galan-Acosta, Lorena, Han, Xuemei, Guo, Yuan, Shan, Bing, Zhang, Yaoyang, Norberg, Erik, Zhang, Tao, Pan, Lifeng, Liu, Junli, Coloff, Jonathan L., Ofengeim, Dimitry, Zhu, Hong, Wu, Kejia, Cai, Yu, Yates, John R., Zhu, Zhengjiang, Yuan, Junying, Vakifahmetoglu-Norberg, Helin
Publicado 2015

Correction: Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death

por Xia, Hong-guang, Najafov, Ayaz, Geng, Jiefei, Galan-Acosta, Lorena, Han, Xuemei, Guo, Yuan, Shan, Bing, Zhang, Yaoyang, Norberg, Erik, Zhang, Tao, Pan, Lifeng, Liu, Junli, Coloff, Jonathan L., Ofengeim, Dimitry, Zhu, Hong, Wu, Kejia, Cai, Yu, Yates, John R., Zhu, Zhengjiang, Yuan, Junying, Vakifahmetoglu-Norberg, Helin
Publicado 2016

Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration

por Ryan, Sean K., Zelic, Matija, Han, Yingnan, Teeple, Erin, Chen, Luoman, Sadeghi, Mahdiar, Shankara, Srinivas, Guo, Lilu, Li, Cong, Pontarelli, Fabrizio, Jensen, Elizabeth H., Comer, Ashley L., Kumar, Dinesh, Zhang, Mindy, Gans, Joseph, Zhang, Bailin, Proto, Jonathan D., Saleh, Jacqueline, Dodge, James C., Savova, Virginia, Rajpal, Deepak, Ofengeim, Dimitry, Hammond, Timothy R.
Publicado 2022

The SARS-CoV-2 main protease M(pro) causes microvascular brain pathology by cleaving NEMO in brain endothelial cells

por Wenzel, Jan, Lampe, Josephine, Müller-Fielitz, Helge, Schuster, Raphael, Zille, Marietta, Müller, Kristin, Krohn, Markus, Körbelin, Jakob, Zhang, Linlin, Özorhan, Ümit, Neve, Vanessa, Wagner, Julian U. G., Bojkova, Denisa, Shumliakivska, Mariana, Jiang, Yun, Fähnrich, Anke, Ott, Fabian, Sencio, Valentin, Robil, Cyril, Pfefferle, Susanne, Sauve, Florent, Coêlho, Caio Fernando Ferreira, Franz, Jonas, Spiecker, Frauke, Lembrich, Beate, Binder, Sonja, Feller, Nina, König, Peter, Busch, Hauke, Collin, Ludovic, Villaseñor, Roberto, Jöhren, Olaf, Altmeppen, Hermann C., Pasparakis, Manolis, Dimmeler, Stefanie, Cinatl, Jindrich, Püschel, Klaus, Zelic, Matija, Ofengeim, Dimitry, Stadelmann, Christine, Trottein, François, Nogueiras, Ruben, Hilgenfeld, Rolf, Glatzel, Markus, Prevot, Vincent, Schwaninger, Markus
Publicado 2021

Apoptotic cell death in disease—Current understanding of the NCCD 2023

por Vitale, Ilio, Pietrocola, Federico, Guilbaud, Emma, Aaronson, Stuart A., Abrams, John M., Adam, Dieter, Agostini, Massimiliano, Agostinis, Patrizia, Alnemri, Emad S., Altucci, Lucia, Amelio, Ivano, Andrews, David W., Aqeilan, Rami I., Arama, Eli, Baehrecke, Eric H., Balachandran, Siddharth, Bano, Daniele, Barlev, Nickolai A., Bartek, Jiri, Bazan, Nicolas G., Becker, Christoph, Bernassola, Francesca, Bertrand, Mathieu J. M., Bianchi, Marco E., Blagosklonny, Mikhail V., Blander, J. Magarian, Blandino, Giovanni, Blomgren, Klas, Borner, Christoph, Bortner, Carl D., Bove, Pierluigi, Boya, Patricia, Brenner, Catherine, Broz, Petr, Brunner, Thomas, Damgaard, Rune Busk, Calin, George A., Campanella, Michelangelo, Candi, Eleonora, Carbone, Michele, Carmona-Gutierrez, Didac, Cecconi, Francesco, Chan, Francis K. -M., Chen, Guo-Qiang, Chen, Quan, Chen, Youhai H., Cheng, Emily H., Chipuk, Jerry E., Cidlowski, John A., Ciechanover, Aaron, Ciliberto, Gennaro, Conrad, Marcus, Cubillos-Ruiz, Juan R., Czabotar, Peter E., D’Angiolella, Vincenzo, Daugaard, Mads, Dawson, Ted M., Dawson, Valina L., De Maria, Ruggero, De Strooper, Bart, Debatin, Klaus-Michael, Deberardinis, Ralph J., Degterev, Alexei, Del Sal, Giannino, Deshmukh, Mohanish, Di Virgilio, Francesco, Diederich, Marc, Dixon, Scott J., Dynlacht, Brian D., El-Deiry, Wafik S., Elrod, John W., Engeland, Kurt, Fimia, Gian Maria, Galassi, Claudia, Ganini, Carlo, Garcia-Saez, Ana J., Garg, Abhishek D., Garrido, Carmen, Gavathiotis, Evripidis, Gerlic, Motti, Ghosh, Sourav, Green, Douglas R., Greene, Lloyd A., Gronemeyer, Hinrich, Häcker, Georg, Hajnóczky, György, Hardwick, J. Marie, Haupt, Ygal, He, Sudan, Heery, David M., Hengartner, Michael O., Hetz, Claudio, Hildeman, David A., Ichijo, Hidenori, Inoue, Satoshi, Jäättelä, Marja, Janic, Ana, Joseph, Bertrand, Jost, Philipp J., Kanneganti, Thirumala-Devi, Karin, Michael, Kashkar, Hamid, Kaufmann, Thomas, Kelly, Gemma L., Kepp, Oliver, Kimchi, Adi, Kitsis, Richard N., Klionsky, Daniel J., Kluck, Ruth, Krysko, Dmitri V., Kulms, Dagmar, Kumar, Sharad, Lavandero, Sergio, Lavrik, Inna N., Lemasters, John J., Liccardi, Gianmaria, Linkermann, Andreas, Lipton, Stuart A., Lockshin, Richard A., López-Otín, Carlos, Luedde, Tom, MacFarlane, Marion, Madeo, Frank, Malorni, Walter, Manic, Gwenola, Mantovani, Roberto, Marchi, Saverio, Marine, Jean-Christophe, Martin, Seamus J., Martinou, Jean-Claude, Mastroberardino, Pier G., Medema, Jan Paul, Mehlen, Patrick, Meier, Pascal, Melino, Gerry, Melino, Sonia, Miao, Edward A., Moll, Ute M., Muñoz-Pinedo, Cristina, Murphy, Daniel J., Niklison-Chirou, Maria Victoria, Novelli, Flavia, Núñez, Gabriel, Oberst, Andrew, Ofengeim, Dimitry, Opferman, Joseph T., Oren, Moshe, Pagano, Michele, Panaretakis, Theocharis, Pasparakis, Manolis, Penninger, Josef M., Pentimalli, Francesca, Pereira, David M., Pervaiz, Shazib, Peter, Marcus E., Pinton, Paolo, Porta, Giovanni, Prehn, Jochen H. M., Puthalakath, Hamsa, Rabinovich, Gabriel A., Rajalingam, Krishnaraj, Ravichandran, Kodi S., Rehm, Markus, Ricci, Jean-Ehrland, Rizzuto, Rosario, Robinson, Nirmal, Rodrigues, Cecilia M. P., Rotblat, Barak, Rothlin, Carla V., Rubinsztein, David C., Rudel, Thomas, Rufini, Alessandro, Ryan, Kevin M., Sarosiek, Kristopher A., Sawa, Akira, Sayan, Emre, Schroder, Kate, Scorrano, Luca, Sesti, Federico, Shao, Feng, Shi, Yufang, Sica, Giuseppe S., Silke, John, Simon, Hans-Uwe, Sistigu, Antonella, Stephanou, Anastasis, Stockwell, Brent R., Strapazzon, Flavie, Strasser, Andreas, Sun, Liming, Sun, Erwei, Sun, Qiang, Szabadkai, Gyorgy, Tait, Stephen W. G., Tang, Daolin, Tavernarakis, Nektarios, Troy, Carol M., Turk, Boris, Urbano, Nicoletta, Vandenabeele, Peter, Vanden Berghe, Tom, Vander Heiden, Matthew G., Vanderluit, Jacqueline L., Verkhratsky, Alexei, Villunger, Andreas, von Karstedt, Silvia, Voss, Anne K., Vousden, Karen H., Vucic, Domagoj, Vuri, Daniela, Wagner, Erwin F., Walczak, Henning, Wallach, David, Wang, Ruoning, Wang, Ying, Weber, Achim, Wood, Will, Yamazaki, Takahiro, Yang, Huang-Tian, Zakeri, Zahra, Zawacka-Pankau, Joanna E., Zhang, Lin, Zhang, Haibing, Zhivotovsky, Boris, Zhou, Wenzhao, Piacentini, Mauro, Kroemer, Guido, Galluzzi, Lorenzo
Publicado 2023