Mechanism of Darunavir (DRV)’s High Genetic Barrier to HIV-1 Resistance: A Key V32I Substitution in Protease Rarely Occurs, but Once It Occurs, It Predisposes HIV-1 To Develop DRV...

por Aoki, Manabu, Das, Debananda, Hayashi, Hironori, Aoki-Ogata, Hiromi, Takamatsu, Yuki, Ghosh, Arun K., Mitsuya, Hiroaki
Publicado 2018

Is human chorionic gonadotropin supplementation beneficial for frozen and thawed embryo transfer in estrogen/progesterone replacement cycles?: A randomized clinical trial

por Shiotani, Masahide, Matsumoto, Yukiko, Okamoto, Eri, Yamada, Satoshi, Mizusawa, Yuri, Furuhashi, Kohyu, Ogata, Hiromi, Ogata, Seiji, Kokeguchi, Shoji
Publicado 2017

Anti‐EGFR scFv tetramer (tetrabody) with a stable monodisperse structure, strong anticancer effect, and a long in vivo half‐life

por Asano, Ryutaro, Koyama, Noriaki, Hagiwara, Yasuyo, Masakari, Yosuke, Orimo, Ryota, Arai, Kyoko, Ogata, Hiromi, Furumoto, Shozo, Umetsu, Mitsuo, Kumagai, Izumi
Publicado 2016

Structural considerations for functional anti-EGFR × anti-CD3 bispecific diabodies in light of domain order and binding affinity

por Asano, Ryutaro, Nagai, Keisuke, Makabe, Koki, Takahashi, Kento, Kumagai, Takashi, Kawaguchi, Hiroko, Ogata, Hiromi, Arai, Kyoko, Umetsu, Mitsuo, Kumagai, Izumi
Publicado 2018

Build-up functionalization of anti-EGFR × anti-CD3 bispecific diabodies by integrating high-affinity mutants and functional molecular formats

por Asano, Ryutaro, Hosokawa, Katsuhiro, Taki, Shintaro, Konno, Shota, Shimomura, Ippei, Ogata, Hiromi, Okada, Mai, Arai, Kyoko, Onitsuka, Masayoshi, Omasa, Takeshi, Nakanishi, Takeshi, Umetsu, Mitsuo, Kumagai, Izumi
Publicado 2020

Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity

por Bulut, Haydar, Hattori, Shin-ichiro, Aoki-Ogata, Hiromi, Hayashi, Hironori, Das, Debananda, Aoki, Manabu, Davis, David A., Rao, Kalapala Venkateswara, Nyalapatla, Prasanth R., Ghosh, Arun K., Mitsuya, Hiroaki
Publicado 2020

Rearranging the domain order of a diabody-based IgG-like bispecific antibody enhances its antitumor activity and improves its degradation resistance and pharmacokinetics

por Asano, Ryutaro, Shimomura, Ippei, Konno, Shota, Ito, Akiko, Masakari, Yosuke, Orimo, Ryota, Taki, Shintaro, Arai, Kyoko, Ogata, Hiromi, Okada, Mai, Furumoto, Shozo, Onitsuka, Masayoshi, Omasa, Takeshi, Hayashi, Hiroki, Katayose, Yu, Unno, Michiaki, Kudo, Toshio, Umetsu, Mitsuo, Kumagai, Izumi
Publicado 2014

GRL-142 binds to and impairs HIV-1 integrase nuclear localization signal and potently suppresses highly INSTI-resistant HIV-1 variants

por Aoki, Manabu, Aoki-Ogata, Hiromi, Bulut, Haydar, Hayashi, Hironori, Takamune, Nobutoki, Kishimoto, Naoki, Tanaka, Hiroki, Higashi-Kuwata, Nobuyo, Hattori, Shin-ichiro, Das, Debananda, Venkateswara Rao, Kalapala, Iwama, Kazuya, Davis, David A., Hasegawa, Kazuya, Murayama, Kazutaka, Yarchoan, Robert, Ghosh, Arun K., Pau, Alice K., Machida, Shinichi, Misumi, Shogo, Mitsuya, Hiroaki
Publicado 2023

A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency

por Aoki, Manabu, Hayashi, Hironori, Rao, Kalapala Venkateswara, Das, Debananda, Higashi-Kuwata, Nobuyo, Bulut, Haydar, Aoki-Ogata, Hiromi, Takamatsu, Yuki, Yedidi, Ravikiran S, Davis, David A, Hattori, Shin-ichiro, Nishida, Noriko, Hasegawa, Kazuya, Takamune, Nobutoki, Nyalapatla, Prasanth R, Osswald, Heather L, Jono, Hirofumi, Saito, Hideyuki, Yarchoan, Robert, Misumi, Shogo, Ghosh, Arun K, Mitsuya, Hiroaki
Publicado 2017