Targeting the undruggable: exploiting neomorphic features of fusion oncoproteins in childhood sarcomas for innovative therapies

por Knott, Maximilian M. L., Hölting, Tilman L. B., Ohmura, Shunya, Kirchner, Thomas, Cidre-Aranaz, Florencia, Grünewald, Thomas G. P.
Publicado 2020

Neomorphic DNA-binding enables tumor-specific therapeutic gene expression in fusion-addicted childhood sarcoma

por Hölting, Tilman L. B., Cidre-Aranaz, Florencia, Matzek, Dana, Popper, Bastian, Jacobi, Severin J., Funk, Cornelius M., Geyer, Florian H., Li, Jing, Piseddu, Ignazio, Cadilha, Bruno L., Ledderose, Stephan, Zwilling, Jennifer, Ohmura, Shunya, Anz, David, Künkele, Annette, Klauschen, Frederick, Grünewald, Thomas G. P., Knott, Maximilian M. L.
Publicado 2022

Targeting the CALCB/RAMP1 axis inhibits growth of Ewing sarcoma

por Dallmayer, Marlene, Li, Jing, Ohmura, Shunya, Alba Rubio, Rebeca, Baldauf, Michaela C., Hölting, Tilman L. B., Musa, Julian, Knott, Max M. L., Stein, Stefanie, Cidre-Aranaz, Florencia, Wehweck, Fabienne S., Romero-Pérez, Laura, Gerke, Julia S., Orth, Martin F., Marchetto, Aruna, Kirchner, Thomas, Bach, Horacio, Sannino, Giuseppina, Grünewald, Thomas G. P.
Publicado 2019

Translational evidence for RRM2 as a prognostic biomarker and therapeutic target in Ewing sarcoma

por Ohmura, Shunya, Marchetto, Aruna, Orth, Martin F., Li, Jing, Jabar, Susanne, Ranft, Andreas, Vinca, Endrit, Ceranski, Katharina, Carreño-Gonzalez, Martha J., Romero-Pérez, Laura, Wehweck, Fabienne S., Musa, Julian, Bestvater, Felix, Knott, Maximilian M. L., Hölting, Tilman L. B., Hartmann, Wolfgang, Dirksen, Uta, Kirchner, Thomas, Cidre-Aranaz, Florencia, Grünewald, Thomas G. P.
Publicado 2021

Robust diagnosis of Ewing sarcoma by immunohistochemical detection of super-enhancer-driven EWSR1-ETS targets

por Baldauf, Michaela C., Orth, Martin F., Dallmayer, Marlene, Marchetto, Aruna, Gerke, Julia S., Rubio, Rebeca Alba, Kiran, Merve M., Musa, Julian, Knott, Maximilian M. L., Ohmura, Shunya, Li, Jing, Akpolat, Nusret, Akatli, Ayse N., Özen, Özlem, Dirksen, Uta, Hartmann, Wolfgang, de Alava, Enrique, Baumhoer, Daniel, Sannino, Giuseppina, Kirchner, Thomas, Grünewald, Thomas G. P.
Publicado 2017

Systematic multi-omics cell line profiling uncovers principles of Ewing sarcoma fusion oncogene-mediated gene regulation

por Orth, Martin F., Surdez, Didier, Faehling, Tobias, Ehlers, Anna C., Marchetto, Aruna, Grossetête, Sandrine, Volckmann, Richard, Zwijnenburg, Danny A., Gerke, Julia S., Zaidi, Sakina, Alonso, Javier, Sastre, Ana, Baulande, Sylvain, Sill, Martin, Cidre-Aranaz, Florencia, Ohmura, Shunya, Kirchner, Thomas, Hauck, Stefanie M., Reischl, Eva, Gymrek, Melissa, Pfister, Stefan M., Strauch, Konstantin, Koster, Jan, Delattre, Olivier, Grünewald, Thomas G.P.
Publicado 2022

Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer

por Li, Jing, Ohmura, Shunya, Marchetto, Aruna, Orth, Martin F., Imle, Roland, Dallmayer, Marlene, Musa, Julian, Knott, Maximilian M. L., Hölting, Tilman L. B., Stein, Stefanie, Funk, Cornelius M., Sastre, Ana, Alonso, Javier, Bestvater, Felix, Kasan, Merve, Romero-Pérez, Laura, Hartmann, Wolfgang, Ranft, Andreas, Banito, Ana, Dirksen, Uta, Kirchner, Thomas, Cidre-Aranaz, Florencia, Grünewald, Thomas G. P.
Publicado 2021

Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma

por Marchetto, Aruna, Ohmura, Shunya, Orth, Martin F., Knott, Maximilian M. L., Colombo, Maria V., Arrigoni, Chiara, Bardinet, Victor, Saucier, David, Wehweck, Fabienne S., Li, Jing, Stein, Stefanie, Gerke, Julia S., Baldauf, Michaela C., Musa, Julian, Dallmayer, Marlene, Romero-Pérez, Laura, Hölting, Tilman L. B., Amatruda, James F., Cossarizza, Andrea, Henssen, Anton G., Kirchner, Thomas, Moretti, Matteo, Cidre-Aranaz, Florencia, Sannino, Giuseppina, Grünewald, Thomas G. P.
Publicado 2020

Publisher Correction: Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma

por Marchetto, Aruna, Ohmura, Shunya, Orth, Martin F., Knott, Maximilian M. L., Colombo, Maria V., Arrigoni, Chiara, Bardinet, Victor, Saucier, David, Wehweck, Fabienne S., Li, Jing, Stein, Stefanie, Gerke, Julia S., Baldauf, Michaela C., Musa, Julian, Dallmayer, Marlene, Romero-Pérez, Laura, Hölting, Tilman L. B., Amatruda, James F., Cossarizza, Andrea, Henssen, Anton G., Kirchner, Thomas, Moretti, Matteo, Cidre-Aranaz, Florencia, Sannino, Giuseppina, Grünewald, Thomas G. P.
Publicado 2020

Gene expression and immunohistochemical analyses identify SOX2 as major risk factor for overall survival and relapse in Ewing sarcoma patients

por Sannino, Giuseppina, Marchetto, Aruna, Ranft, Andreas, Jabar, Susanne, Zacherl, Constanze, Alba-Rubio, Rebeca, Stein, Stefanie, Wehweck, Fabienne S., Kiran, Merve M., Hölting, Tilman L.B., Musa, Julian, Romero-Pérez, Laura, Cidre-Aranaz, Florencia, Knott, Maximilian M.L., Li, Jing, Jürgens, Heribert, Sastre, Ana, Alonso, Javier, Da Silveira, Willian, Hardiman, Gary, Gerke, Julia S., Orth, Martin F., Hartmann, Wolfgang, Kirchner, Thomas, Ohmura, Shunya, Dirksen, Uta, Grünewald, Thomas G.P.
Publicado 2019

High Specificity of BCL11B and GLG1 for EWSR1-FLI1 and EWSR1-ERG Positive Ewing Sarcoma

por Orth, Martin F., Hölting, Tilman L. B., Dallmayer, Marlene, Wehweck, Fabienne S., Paul, Tanja, Musa, Julian, Baldauf, Michaela C., Surdez, Didier, Delattre, Olivier, Knott, Maximilian M. L., Romero-Pérez, Laura, Kasan, Merve, Cidre-Aranaz, Florencia, Gerke, Julia S., Ohmura, Shunya, Li, Jing, Marchetto, Aruna, Henssen, Anton G., Özen, Özlem, Sugita, Shintaro, Hasegawa, Tadashi, Kanaseki, Takayuki, Bertram, Stefanie, Dirksen, Uta, Hartmann, Wolfgang, Kirchner, Thomas, Grünewald, Thomas G. P.
Publicado 2020

Systematic identification of cancer-specific MHC-binding peptides with RAVEN

por Baldauf, Michaela C., Gerke, Julia S., Kirschner, Andreas, Blaeschke, Franziska, Effenberger, Manuel, Schober, Kilian, Rubio, Rebeca Alba, Kanaseki, Takayuki, Kiran, Merve M., Dallmayer, Marlene, Musa, Julian, Akpolat, Nurset, Akatli, Ayse N., Rosman, Fernando C., Özen, Özlem, Sugita, Shintaro, Hasegawa, Tadashi, Sugimura, Haruhiko, Baumhoer, Daniel, Knott, Maximilian M. L., Sannino, Giuseppina, Marchetto, Aruna, Li, Jing, Busch, Dirk H., Feuchtinger, Tobias, Ohmura, Shunya, Orth, Martin F., Thiel, Uwe, Kirchner, Thomas, Grünewald, Thomas G. P.
Publicado 2018

Integrative gene network and functional analyses identify a prognostically relevant key regulator of metastasis in Ewing sarcoma

por Cidre-Aranaz, Florencia, Li, Jing, Hölting, Tilman L. B., Orth, Martin F., Imle, Roland, Kutschmann, Stefanie, Ammirati, Giulia, Ceranski, Katharina, Carreño-Gonzalez, Martha Julia, Kasan, Merve, Marchetto, Aruna, Funk, Cornelius M., Bestvater, Felix, Bersini, Simone, Arrigoni, Chiara, Moretti, Matteo, Thiel, Uwe, Baumhoer, Daniel, Sahm, Felix, Pfister, Stefan M., Hartmann, Wolfgang, Dirksen, Uta, Romero-Pérez, Laura, Banito, Ana, Ohmura, Shunya, Musa, Julian, Kirchner, Thomas, Knott, Maximilian M. L., Grünewald, Thomas G. P.
Publicado 2022

Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes

por Musa, Julian, Cidre-Aranaz, Florencia, Aynaud, Marie-Ming, Orth, Martin F., Knott, Maximilian M. L., Mirabeau, Olivier, Mazor, Gal, Varon, Mor, Hölting, Tilman L. B., Grossetête, Sandrine, Gartlgruber, Moritz, Surdez, Didier, Gerke, Julia S., Ohmura, Shunya, Marchetto, Aruna, Dallmayer, Marlene, Baldauf, Michaela C., Stein, Stefanie, Sannino, Giuseppina, Li, Jing, Romero-Pérez, Laura, Westermann, Frank, Hartmann, Wolfgang, Dirksen, Uta, Gymrek, Melissa, Anderson, Nathaniel D., Shlien, Adam, Rotblat, Barak, Kirchner, Thomas, Delattre, Olivier, Grünewald, Thomas G. P.
Publicado 2019

Sarcoma treatment in the era of molecular medicine

por Grünewald, Thomas GP, Alonso, Marta, Avnet, Sofia, Banito, Ana, Burdach, Stefan, Cidre‐Aranaz, Florencia, Di Pompo, Gemma, Distel, Martin, Dorado‐Garcia, Heathcliff, Garcia‐Castro, Javier, González‐González, Laura, Grigoriadis, Agamemnon E, Kasan, Merve, Koelsche, Christian, Krumbholz, Manuela, Lecanda, Fernando, Lemma, Silvia, Longo, Dario L, Madrigal‐Esquivel, Claudia, Morales‐Molina, Álvaro, Musa, Julian, Ohmura, Shunya, Ory, Benjamin, Pereira‐Silva, Miguel, Perut, Francesca, Rodriguez, Rene, Seeling, Carolin, Al Shaaili, Nada, Shaabani, Shabnam, Shiavone, Kristina, Sinha, Snehadri, Tomazou, Eleni M, Trautmann, Marcel, Vela, Maria, Versleijen‐Jonkers, Yvonne MH, Visgauss, Julia, Zalacain, Marta, Schober, Sebastian J, Lissat, Andrej, English, William R, Baldini, Nicola, Heymann, Dominique
Publicado 2020