Somatic Mutations Reveal Lineage Relationships and Age-Related Mutagenesis in Human Hematopoiesis

por Osorio, Fernando G., Rosendahl Huber, Axel, Oka, Rurika, Verheul, Mark, Patel, Sachin H., Hasaart, Karlijn, de la Fonteijne, Lisanne, Varela, Ignacio, Camargo, Fernando D., van Boxtel, Ruben
Publicado 2018

Genome-wide mapping of transcriptional enhancer candidates using DNA and chromatin features in maize

por Oka, Rurika, Zicola, Johan, Weber, Blaise, Anderson, Sarah N., Hodgman, Charlie, Gent, Jonathan I., Wesselink, Jan-Jaap, Springer, Nathan M., Hoefsloot, Huub C. J., Turck, Franziska, Stam, Maike
Publicado 2017

Mutation Signatures of Pediatric Acute Myeloid Leukemia and Normal Blood Progenitors Associated with Differential Patient Outcomes

por Brandsma, Arianne M., Bertrums, Eline J.M., van Roosmalen, Markus J., Hofman, Damon A., Oka, Rurika, Verheul, Mark, Manders, Freek, Ubels, Joske, Belderbos, Mirjam E., van Boxtel, Ruben
Publicado 2021

MutationalPatterns: the one stop shop for the analysis of mutational processes

por Manders, Freek, Brandsma, Arianne M., de Kanter, Jurrian, Verheul, Mark, Oka, Rurika, van Roosmalen, Markus J., van der Roest, Bastiaan, van Hoeck, Arne, Cuppen, Edwin, van Boxtel, Ruben
Publicado 2022

Evaluating CRISPR-based prime editing for cancer modeling and CFTR repair in organoids

por Geurts, Maarten H, de Poel, Eyleen, Pleguezuelos-Manzano, Cayetano, Oka, Rurika, Carrillo, Léo, Andersson-Rolf, Amanda, Boretto, Matteo, Brunsveld, Jesse E, van Boxtel, Ruben, Beekman, Jeffrey M, Clevers, Hans
Publicado 2021

Molecular characterization of Barrett’s esophagus at single-cell resolution

por Busslinger, Georg A., de Barbanson, Buys, Oka, Rurika, Weusten, Bas L. A., de Maat, Michiel, van Hillegersberg, Richard, Brosens, Lodewijk A. A., van Boxtel, Ruben, van Oudenaarden, Alexander, Clevers, Hans
Publicado 2021

Human induced pluripotent stem cells display a similar mutation burden as embryonic pluripotent cells in vivo

por Hasaart, Karlijn A.L., Manders, Freek, Ubels, Joske, Verheul, Mark, van Roosmalen, Markus J., Groenen, Niels M., Oka, Rurika, Kuijk, Ewart, Lopes, Susana M. Chuva de Sousa, Boxtel, Ruben van
Publicado 2022

Antiviral treatment causes a unique mutational signature in cancers of transplantation recipients

por de Kanter, Jurrian K., Peci, Flavia, Bertrums, Eline, Rosendahl Huber, Axel, van Leeuwen, Anaïs, van Roosmalen, Markus J., Manders, Freek, Verheul, Mark, Oka, Rurika, Brandsma, Arianne M., Bierings, Marc, Belderbos, Mirjam, van Boxtel, Ruben
Publicado 2021

In vivo cytidine base editing of hepatocytes without detectable off-target mutations in RNA and DNA

por Villiger, Lukas, Rothgangl, Tanja, Witzigmann, Dominik, Oka, Rurika, Lin, Paulo J.C., Qi, Weihong, Janjuha, Sharan, Berk, Christian, Ringnalda, Femke, Beattie, Mitchell B., Stoffel, Markus, Thöny, Beat, Hall, Jonathan, Rehrauer, Hubert, van Boxtel, Ruben, Tam, Ying K., Schwank, Gerald
Publicado 2021

Prime editing for functional repair in patient-derived disease models

por Schene, Imre F., Joore, Indi P., Oka, Rurika, Mokry, Michal, van Vugt, Anke H. M., van Boxtel, Ruben, van der Doef, Hubert P. J., van der Laan, Luc J. W., Verstegen, Monique M. A., van Hasselt, Peter M., Nieuwenhuis, Edward E. S., Fuchs, Sabine A.
Publicado 2020

Elevated Mutational Age in Blood of Children Treated for Cancer Contributes to Therapy-Related Myeloid Neoplasms

por Bertrums, Eline J.M., Rosendahl Huber, Axel K.M., de Kanter, Jurrian K., Brandsma, Arianne M., van Leeuwen, Anaïs J.C.N., Verheul, Mark, van den Heuvel-Eibrink, Marry M., Oka, Rurika, van Roosmalen, Markus J., de Groot-Kruseman, Hester A., Zwaan, C. Michel, Goemans, Bianca F., van Boxtel, Ruben
Publicado 2022

Defects in 8-oxo-guanine repair pathway cause high frequency of C > A substitutions in neuroblastoma

por van den Boogaard, Marlinde L., Oka, Rurika, Hakkert, Anne, Schild, Linda, Ebus, Marli E., van Gerven, Michael R., Zwijnenburg, Danny A., Molenaar, Piet, Hoyng, Lieke L., Dolman, M. Emmy M., Essing, Anke H. W., Koopmans, Bianca, Helleday, Thomas, Drost, Jarno, van Boxtel, Ruben, Versteeg, Rogier, Koster, Jan, Molenaar, Jan J.
Publicado 2021

In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels

por Rothgangl, Tanja, Dennis, Melissa K., Lin, Paulo J. C., Oka, Rurika, Witzigmann, Dominik, Villiger, Lukas, Qi, Weihong, Hruzova, Martina, Kissling, Lucas, Lenggenhager, Daniela, Borrelli, Costanza, Egli, Sabina, Frey, Nina, Bakker, Noëlle, Walker, John A., Kadina, Anastasia P., Victorov, Denis V., Pacesa, Martin, Kreutzer, Susanne, Kontarakis, Zacharias, Moor, Andreas, Jinek, Martin, Weissman, Drew, Stoffel, Markus, van Boxtel, Ruben, Holden, Kevin, Pardi, Norbert, Thöny, Beat, Häberle, Johannes, Tam, Ying K., Semple, Sean C., Schwank, Gerald
Publicado 2021

An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity

por Calandrini, Camilla, Schutgens, Frans, Oka, Rurika, Margaritis, Thanasis, Candelli, Tito, Mathijsen, Luka, Ammerlaan, Carola, van Ineveld, Ravian L., Derakhshan, Sepide, de Haan, Sanne, Dolman, Emmy, Lijnzaad, Philip, Custers, Lars, Begthel, Harry, Kerstens, Hindrik H. D., Visser, Lindy L., Rookmaaker, Maarten, Verhaar, Marianne, Tytgat, Godelieve A. M., Kemmeren, Patrick, de Krijger, Ronald R., Al-Saadi, Reem, Pritchard-Jones, Kathy, Kool, Marcel, Rios, Anne C., van den Heuvel-Eibrink, Marry M., Molenaar, Jan J., van Boxtel, Ruben, Holstege, Frank C. P., Clevers, Hans, Drost, Jarno
Publicado 2020