Inhibition of the STAT5/Pim Kinase Axis Enhances Cytotoxic Effects of Proteasome Inhibitors on FLT3-ITD–Positive AML Cells by Cooperatively Inhibiting the mTORC1/4EBP1/S6K/Mcl-1 Pa...

por Nogami, Ayako, Okada, Keigo, Ishida, Shinya, Akiyama, Hiroki, Umezawa, Yoshihiro, Miura, Osamu
Publicado 2018

FLT3-ITD Activates RSK1 to Enhance Proliferation and Survival of AML Cells by Activating mTORC1 and eIF4B Cooperatively with PIM or PI3K and by Inhibiting Bad and BIM

por Watanabe, Daisuke, Nogami, Ayako, Okada, Keigo, Akiyama, Hiroki, Umezawa, Yoshihiro, Miura, Osamu
Publicado 2019

Successful treatment with bortezomib for refractory fever associated with myelodysplastic syndrome with underlying lymphoplasmacytic lymphoma

por Motomura, Yotaro, Umezawa, Yoshihiro, Arimatsu, Tomoyuki, Okada, Keigo, Miura, Osamu, Kumagai, Takashi
Publicado 2022

FLT3-ITD induces expression of Pim kinases through STAT5 to confer resistance to the PI3K/Akt pathway inhibitors on leukemic cells by enhancing the mTORC1/Mcl-1 pathway

por Okada, Keigo, Nogami, Ayako, Ishida, Shinya, Akiyama, Hiroki, Chen, Cheng, Umezawa, Yoshihiro, Miura, Osamu
Publicado 2017

Inhibition of USP9X Downregulates JAK2-V617F and Induces Apoptosis Synergistically with BH3 Mimetics Preferentially in Ruxolitinib-Persistent JAK2-V617F-Positive Leukemic Cells

por Akiyama, Hiroki, Umezawa, Yoshihiro, Watanabe, Daisuke, Okada, Keigo, Ishida, Shinya, Nogami, Ayako, Miura, Osamu
Publicado 2020

Efficacy and Safety of Balloon Kyphoplasty for Pathological Vertebral Fractures in Patients with Hematological Malignancies in Our Institution

por Okada, Keigo, Fujiwara, Hiroki, Arimatsu, Tomoyuki, Motomura, Yotaro, Kato, Tsuyoshi, Takezako, Naoki, Kumagai, Takashi
Publicado 2020

FLT3-ITD confers resistance to the PI3K/Akt pathway inhibitors by protecting the mTOR/4EBP1/Mcl-1 pathway through STAT5 activation in acute myeloid leukemia

por Nogami, Ayako, Oshikawa, Gaku, Okada, Keigo, Fukutake, Shusaku, Umezawa, Yoshihiro, Nagao, Toshikage, Kurosu, Tetsuya, Miura, Osamu
Publicado 2015

Mechanisms for mTORC1 activation and synergistic induction of apoptosis by ruxolitinib and BH3 mimetics or autophagy inhibitors in JAK2-V617F-expressing leukemic cells including ne...

por Ishida, Shinya, Akiyama, Hiroki, Umezawa, Yoshihiro, Okada, Keigo, Nogami, Ayako, Oshikawa, Gaku, Nagao, Toshikage, Miura, Osamu
Publicado 2018

A novel chimeric antigen receptor (CAR) system using an exogenous protease, in which activation of T cells is controlled by expression patterns of cell-surface proteins on target c...

por Aoyama, Satoru, Yasuda, Shunichiro, Li, Huixin, Watanabe, Daisuke, Umezawa, Yoshihiro, Okada, Keigo, Nogami, Ayako, Miura, Osamu, Kawamata, Norihiko
Publicado 2022

An Antibody-Drug Conjugate That Selectively Targets Human Monocyte Progenitors for Anti-Cancer Therapy

por Izumi, Yuta, Kanayama, Masashi, Shen, Zhongchuzi, Kai, Masayuki, Kawamura, Shunsuke, Akiyama, Megumi, Yamamoto, Masahide, Nagao, Toshikage, Okada, Keigo, Kawamata, Norihiko, Toyota, Shigeo, Ohteki, Toshiaki
Publicado 2021

Lymphoproliferative disorder risk after methotrexate treatment for rheumatoid arthritis

por Tanaka, Keisuke, Ichikawa, Ayako, Umezawa, Natsuka, Yamamoto, Kouhei, Yoshifuji, Kota, Okada, Keigo, Nogami, Ayako, Umezawa, Yoshihiro, Nagao, Toshikage, Sakashita, Chizuko, Mori, Takehiko, Tohda, Shuji, Koike, Ryuji, Yasuda, Shinsuke, Yamamoto, Masahide
Publicado 2023