A novel thiophene‐3‐carboxamide analog of annonaceous acetogenin exhibits antitumor activity via inhibition of mitochondrial complex I

por Akatsuka, Akinobu, Kojima, Naoto, Okamura, Mutsumi, Dan, Shingo, Yamori, Takao
Publicado 2016

Structure–antitumor activity relationship of hybrid acetogenins focusing on connecting groups between heterocycles and the linker moiety

por Ohta, Kaito, Fushimi, Tetsuya, Okamura, Mutsumi, Akatsuka, Akinobu, Dan, Shingo, Iwasaki, Hiroki, Yamashita, Masayuki, Kojima, Naoto
Publicado 2022

Loss of the Phenolic Hydroxyl Group and Aromaticity from the Side Chain of Anti-Proliferative 10-Methyl-aplog-1, a Simplified Analog of Aplysiatoxin, Enhances Its Tumor-Promoting a...

por Hanaki, Yusuke, Kikumori, Masayuki, Tokuda, Harukuni, Okamura, Mutsumi, Dan, Shingo, Adachi, Naoko, Saito, Naoaki, Yanagita, Ryo C., Irie, Kazuhiro
Publicado 2017

Subtype-selective induction of apoptosis in translocation-related sarcoma cells induced by PUMA and BIM upon treatment with pan-PI3K inhibitors

por Isoyama, Sho, Tamaki, Naomi, Noguchi, Yutaka, Okamura, Mutsumi, Yoshimatsu, Yuki, Kondo, Tadashi, Suzuki, Takeshi, Yaguchi, Shin-ichi, Dan, Shingo
Publicado 2023

AMF-26, a Novel Inhibitor of the Golgi System, Targeting ADP-ribosylation Factor 1 (Arf1) with Potential for Cancer Therapy

por Ohashi, Yoshimi, Iijima, Hiroshi, Yamaotsu, Noriyuki, Yamazaki, Kanami, Sato, Shigeo, Okamura, Mutsumi, Sugimoto, Kenji, Dan, Shingo, Hirono, Shuichi, Yamori, Takao
Publicado 2012

Basal expression of insulin-like growth factor 1 receptor determines intrinsic resistance of cancer cells to a phosphatidylinositol 3-kinase inhibitor ZSTK474

por Isoyama, Sho, Kajiwara, Gensei, Tamaki, Naomi, Okamura, Mutsumi, Yoshimi, Hisashi, Nakamura, Naoki, Kawamura, Kento, Nishimura, Yumiko, Namatame, Nachi, Yamori, Takao, Dan, Shingo
Publicado 2015

Antitumor profile of the PI3K inhibitor ZSTK474 in human sarcoma cell lines

por Namatame, Nachi, Tamaki, Naomi, Yoshizawa, Yuya, Okamura, Mutsumi, Nishimura, Yumiko, Yamazaki, Kanami, Tanaka, Miwa, Nakamura, Takuro, Semba, Kentaro, Yamori, Takao, Yaguchi, Shin-ichi, Dan, Shingo
Publicado 2018

Targeting the Golgi apparatus to overcome acquired resistance of non-small cell lung cancer cells to EGFR tyrosine kinase inhibitors

por Ohashi, Yoshimi, Okamura, Mutsumi, Katayama, Ryohei, Fang, Siyang, Tsutsui, Saki, Akatsuka, Akinobu, Shan, Mingde, Choi, Hyeong-Wook, Fujita, Naoya, Yoshimatsu, Kentaro, Shiina, Isamu, Yamori, Takao, Dan, Shingo
Publicado 2017