A new brain‐penetrant glucosylceramide synthase inhibitor as potential Therapeutics for Gaucher disease

por Fujii, Takahiro, Tanaka, Yuta, Oki, Hideyuki, Sato, Sho, Shibata, Sachio, Maru, Takamitsu, Tanaka, Yuta, Tanaka, Maiko, Onishi, Tomohiro
Publicado 2021

LSD1 enzyme inhibitor TAK-418 unlocks aberrant epigenetic machinery and improves autism symptoms in neurodevelopmental disorder models

por Baba, Rina, Matsuda, Satoru, Arakawa, Yuuichi, Yamada, Ryuji, Suzuki, Noriko, Ando, Tatsuya, Oki, Hideyuki, Igaki, Shigeru, Daini, Masaki, Hattori, Yasushi, Matsumoto, Shigemitsu, Ito, Mitsuhiro, Nakatani, Atsushi, Kimura, Haruhide
Publicado 2021

Design, Synthesis, and Biological Evaluation of a Novel Series of 4-Guanidinobenzoate Derivatives as Enteropeptidase Inhibitors with Low Systemic Exposure for the Treatment of Obes...

por Ikeda, Zenichi, Kakegawa, Keiko, Kikuchi, Fumiaki, Itono, Sachiko, Oki, Hideyuki, Yashiro, Hiroaki, Hiyoshi, Hideyuki, Tsuchimori, Kazue, Hamagami, Kenichi, Watanabe, Masanori, Sasaki, Masako, Ishihara, Youko, Tohyama, Kimio, Kitazaki, Tomoyuki, Maekawa, Tsuyoshi, Sasaki, Minoru
Publicado 2022