GBT440 reverses sickling of sickled red blood cells under hypoxic conditions in vitro

por Dufu, Kobina, Oksenberg, Donna
Publicado 2018

GBT440 Inhibits Sickling of Sickle Cell Trait Blood Under In Vitro Conditions Mimicking Strenuous Exercise

por Dufu, Kobina, Lehrer-Graiwer, Josh, Ramos, Eleanor, Oksenberg, Donna
Publicado 2016

Rheological Impact of GBT1118 Cessation in a Sickle Mouse Model

por Kanne, Celeste K., Nebor, Danitza, Pochron, Mira, Oksenberg, Donna, Sheehan, Vivien A.
Publicado 2021

Development and validation of an oxygen dissociation assay, a screening platform for discovering, and characterizing hemoglobin–oxygen affinity modifiers

por Patel, Mira P, Siu, Vincent, Silva-Garcia, Abel, Xu, Qing, Li, Zhe, Oksenberg, Donna
Publicado 2018

Pharmacokinetics and pharmacodynamics of voxelotor (GBT440) in healthy adults and patients with sickle cell disease

por Hutchaleelaha, Athiwat, Patel, Mira, Washington, Carla, Siu, Vincent, Allen, Elizabeth, Oksenberg, Donna, Gretler, Daniel D., Mant, Timothy, Lehrer‐Graiwer, Josh
Publicado 2019

A Pharmacological Screening Approach for Discovery of Neuroprotective Compounds in Ischemic Stroke

por Beraki, Simret, Litrus, Lily, Soriano, Liza, Monbureau, Marie, To, Lillian K., Braithwaite, Steven P., Nikolich, Karoly, Urfer, Roman, Oksenberg, Donna, Shamloo, Mehrdad
Publicado 2013

The effect of the antisickling compound GBT1118 on the permeability of red blood cells from patients with sickle cell anemia

por Al Balushi, Halima, Dufu, Kobina, Rees, David C., Brewin, John N., Hannemann, Anke, Oksenberg, Donna, Lu, David C.‐Y., Gibson, John S.
Publicado 2019

Increased hemoglobin–oxygen affinity ameliorates bleomycin‐induced hypoxemia and pulmonary fibrosis

por Geng, Xin, Dufu, Kobina, Hutchaleelaha, Athiwat, Xu, Qing, Li, Zhe, Li, Chien‐Ming, Patel, Mira P., Vlahakis, Nicholas, Lehrer‐Graiwer, Josh, Oksenberg, Donna
Publicado 2016

Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin

por Metcalf, Brian, Chuang, Chihyuan, Dufu, Kobina, Patel, Mira P., Silva-Garcia, Abel, Johnson, Carl, Lu, Qing, Partridge, James R., Patskovska, Larysa, Patskovsky, Yury, Almo, Steven C., Jacobson, Matthew P., Hua, Lan, Xu, Qing, Gwaltney, Stephen L., Yee, Calvin, Harris, Jason, Morgan, Bradley P., James, Joyce, Xu, Donghong, Hutchaleelaha, Athiwat, Paulvannan, Kumar, Oksenberg, Donna, Li, Zhe
Publicado 2017