Trypanosoma brucei pteridine reductase 1 is essential for survival in vitro and for virulence in mice

por Sienkiewicz, Natasha, Ong, Han B, Fairlamb, Alan H
Publicado 2010

Characterisation of a putative glutamate 5‐kinase from Leishmania donovani

por Sienkiewicz, Natasha, Ong, Han B., Fairlamb, Alan H.
Publicado 2018

Dissecting the Metabolic Roles of Pteridine Reductase 1 in Trypanosoma brucei and Leishmania major

por Ong, Han B., Sienkiewicz, Natasha, Wyllie, Susan, Fairlamb, Alan H.
Publicado 2011

Trypanosoma brucei (UMP synthase null mutants) are avirulent in mice, but recover virulence upon prolonged culture in vitro while retaining pyrimidine auxotrophy

por Ong, Han B, Sienkiewicz, Natasha, Wyllie, Susan, Patterson, Stephen, Fairlamb, Alan H
Publicado 2013

Homoserine and quorum-sensing acyl homoserine lactones as alternative sources of threonine: a potential role for homoserine kinase in insect-stage Trypanosoma brucei

por Ong, Han B, Lee, Wai S, Patterson, Stephen, Wyllie, Susan, Fairlamb, Alan H
Publicado 2015

Trypanosoma brucei DHFR-TS Revisited: Characterisation of a Bifunctional and Highly Unstable Recombinant Dihydrofolate Reductase-Thymidylate Synthase

por Gibson, Marc W., Dewar, Simon, Ong, Han B., Sienkiewicz, Natasha, Fairlamb, Alan H.
Publicado 2016

The Role of Folate Transport in Antifolate Drug Action in Trypanosoma brucei

por Dewar, Simon, Sienkiewicz, Natasha, Ong, Han B., Wall, Richard J., Horn, David, Fairlamb, Alan H.
Publicado 2016

Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase

por Shanks, Emma J., Ong, Han B., Robinson, David A., Thompson, Stephen, Sienkiewicz, Natasha, Fairlamb, Alan H., Frearson, Julie A.
Publicado 2010

Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome

por Jones, Deuan C., Foth, Bernardo J., Urbaniak, Michael D., Patterson, Stephen, Ong, Han B., Berriman, Matthew, Fairlamb, Alan H.
Publicado 2015

Systematic identification of genes encoding cell surface and secreted proteins that are essential for in vitro growth and infection in Leishmania donovani

por Roberts, Adam J., Ong, Han B., Clare, Simon, Brandt, Cordelia, Harcourt, Katherine, Franssen, Susanne U., Cotton, James A., Müller-Sienerth, Nicole, Wright, Gavin J.
Publicado 2022

Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1

por Spinks, Daniel, Ong, Han B, Mpamhanga, Chidochangu P, Shanks, Emma J, Robinson, David A, Collie, Iain T, Read, Kevin D, Frearson, Julie A, Wyatt, Paul G, Brenk, Ruth, Fairlamb, Alan H, Gilbert, Ian H
Publicado 2011