How many kinases are druggable? A review of our current understanding

por Anderson, Brian, Rosston, Peter, Ong, Han Wee, Hossain, Mohammad Anwar, Davis-Gilbert, Zachary W., Drewry, David H.
Publicado 2023

Optimization of 3-Cyano-7-cyclopropylamino-pyrazolo[1,5-a]pyrimidines Toward the Development of an In Vivo Chemical Probe for CSNK2A

por Yang, Xuan, Ong, Han Wee, Dickmander, Rebekah J., Smith, Jeffery L., Brown, Jason W., Tao, William, Chang, Edcon, Moorman, Nathaniel J., Axtman, Alison D., Willson, Timothy M.
Publicado 2023

Optimization of 3-Cyano-7-cyclopropylamino-pyrazolo[1,5-a]pyrimidines toward the Development of an In Vivo Chemical Probe for CSNK2A

por Yang, Xuan, Ong, Han Wee, Dickmander, Rebekah J., Smith, Jeffery L., Brown, Jason W., Tao, William, Chang, Edcon, Moorman, Nathaniel J., Axtman, Alison D., Willson, Timothy M.
Publicado 2023

Identification of Novel 2,4,5-Trisubstituted Pyrimidines as Potent Dual Inhibitors of Plasmodial PfGSK3/PfPK6 with Activity against Blood Stage Parasites In Vitro

por Galal, Kareem A., Truong, Anna, Kwarcinski, Frank, de Silva, Chandi, Avalani, Krisha, Havener, Tammy M., Chirgwin, Michael E., Merten, Eric, Ong, Han Wee, Willis, Caleb, Abdelwaly, Ahmad, Helal, Mohamed A., Derbyshire, Emily R., Zutshi, Reena, Drewry, David H.
Publicado 2022

Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective

por Ong, Han Wee, Liang, Yi, Richardson, William, Lowry, Emily R., Wells, Carrow I., Chen, Xiangrong, Silvestre, Margaux, Dempster, Kelvin, Silvaroli, Josie A., Smith, Jeffery L., Wichterle, Hynek, Pabla, Navjot S., Ultanir, Sila K., Bullock, Alex N., Drewry, David H., Axtman, Alison D.
Publicado 2023

A Potent and Selective CDKL5/GSK3 Chemical Probe is Neuroprotective

por Ong, Han Wee, Liang, Yi, Richardson, William, Lowry, Emily R., Wells, Carrow I., Chen, Xiangrong, Silvestre, Margaux, Dempster, Kelvin, Silvaroli, Josie A., Smith, Jeffery L., Wichterle, Hynek, Pabla, Navjot S., Ultanir, Sila K., Bullock, Alex N., Drewry, David H., Axtman, Alison D.
Publicado 2023

Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology

por Castano, Anna, Silvestre, Margaux, Wells, Carrow I, Sanderson, Jennifer L, Ferrer, Carla A, Ong, Han Wee, Lang, Yi, Richardson, William, Silvaroli, Josie A, Bashore, Frances M, Smith, Jeffery L, Genereux, Isabelle M, Dempster, Kelvin, Drewry, David H, Pabla, Navlot S, Bullock, Alex N, Benke, Tim A, Ultanir, Sila K, Axtman, Alison D
Publicado 2023