Abnormal Metabolism in the Progression of Nonalcoholic Fatty Liver Disease to Hepatocellular Carcinoma: Mechanistic Insights to Chemoprevention

por Orabi, Danny, Berger, Nathan A., Brown, J. Mark
Publicado 2021

Flavin-Containing Monooxygenase 3 (FMO3) Is Critical for Dioxin-Induced Reorganization of the Gut Microbiome and Host Insulin Sensitivity

por Massey, William, Osborn, Lucas J., Banerjee, Rakhee, Horak, Anthony, Fung, Kevin K., Orabi, Danny, Chan, E. Ricky, Sangwan, Naseer, Wang, Zeneng, Brown, J. Mark
Publicado 2022

A surgical method for continuous intraportal infusion of gut microbial metabolites in mice

por Orabi, Danny, Osborn, Lucas J., Fung, Kevin, Massey, William, Horak, Anthony J., Aucejo, Federico, Choucair, Ibrahim, DeLucia, Beckey, Wang, Zeneng, Claesen, Jan, Brown, J. Mark
Publicado 2021

A Single Human-Relevant Fast Food Meal Rapidly Reorganizes Metabolomic and Transcriptomic Signatures in a Gut Microbiota-Dependent Manner

por Osborn, Lucas J., Orabi, Danny, Goudzari, Maryam, Sangwan, Naseer, Banerjee, Rakhee, Brown, Amanda L., Kadam, Anagha, Gromovsky, Anthony D., Linga, Pranavi, Cresci, Gail A. M., Mak, Tytus D., Willard, Belinda B., Claesen, Jan, Brown, J. Mark
Publicado 2021

A gut microbial metabolite of dietary polyphenols reverses obesity-driven hepatic steatosis

por Osborn, Lucas J., Schultz, Karlee, Massey, William, DeLucia, Beckey, Choucair, Ibrahim, Varadharajan, Venkateshwari, Banerjee, Rakhee, Fung, Kevin, Horak, Anthony J., Orabi, Danny, Nemet, Ina, Nagy, Laura E., Wang, Zeneng, Allende, Daniela S., Willard, Belinda B., Sangwan, Naseer, Hajjar, Adeline M., McDonald, Christine, Ahern, Philip P., Hazen, Stanley L., Brown, J. Mark, Claesen, Jan
Publicado 2022

Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease

por Helsley, Robert N, Varadharajan, Venkateshwari, Brown, Amanda L, Gromovsky, Anthony D, Schugar, Rebecca C, Ramachandiran, Iyappan, Fung, Kevin, Kabbany, Mohammad Nasser, Banerjee, Rakhee, Neumann, Chase K, Finney, Chelsea, Pathak, Preeti, Orabi, Danny, Osborn, Lucas J, Massey, William, Zhang, Renliang, Kadam, Anagha, Sansbury, Brian E, Pan, Calvin, Sacks, Jessica, Lee, Richard G, Crooke, Rosanne M, Graham, Mark J, Lemieux, Madeleine E, Gogonea, Valentin, Kirwan, John P, Allende, Daniela S, Civelek, Mete, Fox, Paul L, Rudel, Lawrence L, Lusis, Aldons J, Spite, Matthew, Brown, J Mark
Publicado 2019

Gut microbe-targeted choline trimethylamine lyase inhibition improves obesity via rewiring of host circadian rhythms

por Schugar, Rebecca C, Gliniak, Christy M, Osborn, Lucas J, Massey, William, Sangwan, Naseer, Horak, Anthony, Banerjee, Rakhee, Orabi, Danny, Helsley, Robert N, Brown, Amanda L, Burrows, Amy, Finney, Chelsea, Fung, Kevin K, Allen, Frederick M, Ferguson, Daniel, Gromovsky, Anthony D, Neumann, Chase, Cook, Kendall, McMillan, Amy, Buffa, Jennifer A, Anderson, James T, Mehrabian, Margarete, Goudarzi, Maryam, Willard, Belinda, Mak, Tytus D, Armstrong, Andrew R, Swanson, Garth, Keshavarzian, Ali, Garcia-Garcia, Jose Carlos, Wang, Zeneng, Lusis, Aldons J, Hazen, Stanley L, Brown, Jonathan Mark
Publicado 2022

Gut microbial trimethylamine is elevated in alcohol-associated hepatitis and contributes to ethanol-induced liver injury in mice

por Helsley, Robert N, Miyata, Tatsunori, Kadam, Anagha, Varadharajan, Venkateshwari, Sangwan, Naseer, Huang, Emily C, Banerjee, Rakhee, Brown, Amanda L, Fung, Kevin K, Massey, William J, Neumann, Chase, Orabi, Danny, Osborn, Lucas J, Schugar, Rebecca C, McMullen, Megan R, Bellar, Annette, Poulsen, Kyle L, Kim, Adam, Pathak, Vai, Mrdjen, Marko, Anderson, James T, Willard, Belinda, McClain, Craig J, Mitchell, Mack, McCullough, Arthur J, Radaeva, Svetlana, Barton, Bruce, Szabo, Gyongyi, Dasarathy, Srinivasan, Garcia-Garcia, Jose Carlos, Rotroff, Daniel M, Allende, Daniela S, Wang, Zeneng, Hazen, Stanley L, Nagy, Laura E, Brown, Jonathan Mark
Publicado 2022