The G9a Histone Methyltransferase Inhibitor BIX-01294 Modulates Gene Expression during Plasmodium falciparum Gametocyte Development and Transmission

por Ngwa, Che Julius, Kiesow, Meike Jutta, Orchard, Lindsey Marie, Farrukh, Afia, Llinás, Manuel, Pradel, Gabriele
Publicado 2019

H3K36 methylation reprograms gene expression to drive early gametocyte development in Plasmodium falciparum

por Connacher, Jessica, Josling, Gabrielle A., Orchard, Lindsey M., Reader, Janette, Llinás, Manuel, Birkholtz, Lyn-Marié
Publicado 2021

Dissecting the role of PfAP2-G in malaria gametocytogenesis

por Josling, Gabrielle A., Russell, Timothy J., Venezia, Jarrett, Orchard, Lindsey, van Biljon, Riëtte, Painter, Heather J., Llinás, Manuel
Publicado 2020

Refining the transcriptome of the human malaria parasite Plasmodium falciparum using amplification-free RNA-seq

por Chappell, Lia, Ross, Philipp, Orchard, Lindsey, Russell, Timothy J., Otto, Thomas D., Berriman, Matthew, Rayner, Julian C., Llinás, Manuel
Publicado 2020

Hierarchical transcriptional control regulates Plasmodium falciparum sexual differentiation

por van Biljon, Riëtte, van Wyk, Roelof, Painter, Heather J., Orchard, Lindsey, Reader, Janette, Niemand, Jandeli, Llinás, Manuel, Birkholtz, Lyn-Marie
Publicado 2019

Transcriptional Profiling Defines Histone Acetylation as a Regulator of Gene Expression during Human-to-Mosquito Transmission of the Malaria Parasite Plasmodium falciparum

por Ngwa, Che J., Kiesow, Meike J., Papst, Olga, Orchard, Lindsey M., Filarsky, Michael, Rosinski, Alina N., Voss, Till S., Llinás, Manuel, Pradel, Gabriele
Publicado 2017

Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages

por Okombo, John, Mok, Sachel, Qahash, Tarrick, Yeo, Tomas, Bath, Jade, Orchard, Lindsey M., Owens, Edward, Koo, Imhoi, Albert, Istvan, Llinás, Manuel, Fidock, David A.
Publicado 2022

The transcriptional regulator HDP1 controls expansion of the inner membrane complex during early sexual differentiation of malaria parasites

por Campelo Morillo, Riward A., Tong, Xinran, Xie, Wei, Abel, Steven, Orchard, Lindsey M., Daher, Wassim, Patel, Dinshaw J., Llinás, Manuel, Le Roch, Karine G., Kafsack, Björn F.C.
Publicado 2022

Characterization of the Plasmodium falciparum and P. berghei glycerol 3‐phosphate acyltransferase involved in FASII fatty acid utilization in the malaria parasite apicoplast

por Shears, Melanie J., MacRae, James I., Mollard, Vanessa, Goodman, Christopher D., Sturm, Angelika, Orchard, Lindsey M., Llinás, Manuel, McConville, Malcolm J., Botté, Cyrille Y., McFadden, Geoffrey I.
Publicado 2016

A seven-helix protein constitutes stress granules crucial for regulating translation during human-to-mosquito transmission of Plasmodium falciparum

por Bennink, Sandra, von Bohl, Andreas, Ngwa, Che J., Henschel, Leonie, Kuehn, Andrea, Pilch, Nicole, Weißbach, Tim, Rosinski, Alina N., Scheuermayer, Matthias, Repnik, Urska, Przyborski, Jude M., Minns, Allen M., Orchard, Lindsey M., Griffiths, Gareth, Lindner, Scott E., Llinás, Manuel, Pradel, Gabriele
Publicado 2018

A single-nucleotide polymorphism in a Plasmodium berghei ApiAP2 transcription factor alters the development of host immunity

por Akkaya, Munir, Bansal, Abhisheka, Sheehan, Patrick W., Pena, Mirna, Molina-Cruz, Alvaro, Orchard, Lindsey M., Cimperman, Clare K., Qi, Chen-Feng, Ross, Philipp, Yazew, Takele, Sturdevant, Daniel, Anzick, Sarah L., Thiruvengadam, Girija, Otto, Thomas Dan, Billker, Oliver, Llinás, Manuel, Miller, Louis H., Pierce, Susan K.
Publicado 2020

Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box

por Reader, Janette, van der Watt, Mariëtte E., Taylor, Dale, Le Manach, Claire, Mittal, Nimisha, Ottilie, Sabine, Theron, Anjo, Moyo, Phanankosi, Erlank, Erica, Nardini, Luisa, Venter, Nelius, Lauterbach, Sonja, Bezuidenhout, Belinda, Horatscheck, Andre, van Heerden, Ashleigh, Spillman, Natalie J., Cowell, Anne N., Connacher, Jessica, Opperman, Daniel, Orchard, Lindsey M., Llinás, Manuel, Istvan, Eva S., Goldberg, Daniel E., Boyle, Grant A., Calvo, David, Mancama, Dalu, Coetzer, Theresa L., Winzeler, Elizabeth A., Duffy, James, Koekemoer, Lizette L., Basarab, Gregory, Chibale, Kelly, Birkholtz, Lyn-Marié
Publicado 2021