Sphingolipid biosynthesis induces a conformational change in the murine norovirus receptor and facilitates viral infection

por Orchard, Robert C., Wilen, Craig B., Virgin, Herbert W.
Publicado 2018

A systematic exploration of the interactions between bacterial effector proteins and host cell membranes

por Weigele, Bethany A., Orchard, Robert C., Jimenez, Alyssa, Cox, Gregory W., Alto, Neal M.
Publicado 2017

Genome-wide CRISPR activation screen identifies JADE3 as an antiviral activator of NF-kB

por Munir, Moiz, Embry, Aaron, Doench, John G., Heaton, Nicholas S., Wilen, Craig B., Orchard, Robert C.
Publicado 2023

A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human Cells

por Selleck, Elizabeth M., Orchard, Robert C., Lassen, Kara G., Beatty, Wandy L., Xavier, Ramnik J., Levine, Beth, Virgin, Herbert W., Sibley, L. David
Publicado 2015

CD300LF Polymorphisms of Inbred Mouse Strains Confer Resistance to Murine Norovirus Infection in a Cell Type-Dependent Manner

por Furlong, Kevin, Biering, Scott B., Choi, Jayoung, Wilen, Craig B., Orchard, Robert C., Wobus, Christiane E., Nelson, Christopher A., Fremont, Daved H., Baldridge, Megan T., Randall, Glenn, Hwang, Seungmin
Publicado 2020

Structural basis for murine norovirus engagement of bile acids and the CD300lf receptor

por Nelson, Christopher A., Wilen, Craig B., Dai, Ya-Nan, Orchard, Robert C., Kim, Arthur S., Stegeman, Roderick A., Hsieh, Leon L., Smith, Thomas J., Virgin, Herbert W., Fremont, Daved H.
Publicado 2018

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

por Doench, John G., Fusi, Nicolo, Sullender, Meagan, Hegde, Mudra, Vaimberg, Emma W., Donovan, Katherine F., Smith, Ian, Tothova, Zuzana, Wilen, Craig, Orchard, Robert, Virgin, Herbert W., Listgarten, Jennifer, Root, David E.
Publicado 2016

Tuft-cell-intrinsic and -extrinsic mediators of norovirus tropism regulate viral immunity

por Strine, Madison S., Alfajaro, Mia Madel, Graziano, Vincent R., Song, Jaewon, Hsieh, Leon L., Hill, Ryan, Guo, Jun, VanDussen, Kelli L., Orchard, Robert C., Baldridge, Megan T., Lee, Sanghyun, Wilen, Craig B.
Publicado 2022

Reovirus infection is regulated by NPC1 and endosomal cholesterol homeostasis

por Ortega-Gonzalez, Paula, Taylor, Gwen, Jangra, Rohit K., Tenorio, Raquel, Fernandez de Castro, Isabel, Mainou, Bernardo A., Orchard, Robert C., Wilen, Craig B., Brigleb, Pamela H., Sojati, Jorna, Chandran, Kartik, Sachse, Martin, Risco, Cristina, Dermody, Terence S.
Publicado 2022

The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expression

por Wei, Jin, Alfajaro, Mia Madel, Cai, Wesley L., Graziano, Vincent R., Strine, Madison S., Filler, Renata B., Biering, Scott B., Sarnik, Sylvia A., Patel, Sonam, Menasche, Bridget L., Compton, Susan R., Konermann, Silvana, Hsu, Patrick D., Orchard, Robert C., Yan, Qin, Wilen, Craig B.
Publicado 2023

CD300lf is the primary physiologic receptor of murine norovirus but not human norovirus

por Graziano, Vincent R., Walker, Forrest C., Kennedy, Elizabeth A., Wei, Jin, Ettayebi, Khalil, Strine, Madison S., Filler, Renata B., Hassan, Ebrahim, Hsieh, Leon L., Kim, Arthur S., Kolawole, Abimbola O., Wobus, Christiane E., Lindesmith, Lisa C., Baric, Ralph S., Estes, Mary K., Orchard, Robert C., Baldridge, Megan T., Wilen, Craig B.
Publicado 2020

Select autophagy genes maintain quiescence of tissue-resident macrophages and increase susceptibility to Listeria monocytogenes

por Wang, Ya-Ting, Zaitsev, Konstantin, Lu, Qun, Li, Shan, Schaiff, W. Timothy, Kim, Ki-Wook, Droit, Lindsay, Wilen, Craig B., Desai, Chandni, Balce, Dale R., Orchard, Robert C., Orvedahl, Anthony, Park, Sunmin, Kreamalmeyer, Darren, Handley, Scott A., Pfeifer, John D., Baldridge, Megan T., Artyomov, Maxim N., Stallings, Christina L, Virgin, Herbert W.
Publicado 2020

Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival

por Redmann, Veronika, Lamb, Christopher A., Hwang, Seungmin, Orchard, Robert C., Kim, Sungsu, Razi, Minoo, Milam, Ashley, Park, Sunmin, Yokoyama, Christine C., Kambal, Amal, Kreamalmeyer, Darren, Bosch, Marie K., Xiao, Maolei, Green, Karen, Kim, Jungsu, Pruett-Miller, Shondra M., Ornitz, David M., Allen, Paul M., Beatty, Wandy L., Schmidt, Robert E., DiAntonio, Aaron, Tooze, Sharon A., Virgin, Herbert W.
Publicado 2016

Genome-wide CRISPR screen reveals host genes that regulate SARS-CoV-2 infection

por Wei, Jin, Alfajaro, Mia Madel, Hanna, Ruth E., DeWeirdt, Peter C., Strine, Madison S., Lu-Culligan, William J., Zhang, Shang-Min, Graziano, Vincent R., Schmitz, Cameron O., Chen, Jennifer S., Mankowski, Madeleine C., Filler, Renata B., Gasque, Victor, de Miguel, Fernando, Chen, Huacui, Oguntuyo, Kasopefoluwa, Abriola, Laura, Surovtseva, Yulia V., Orchard, Robert C., Lee, Benhur, Lindenbach, Brett, Politi, Katerina, van Dijk, David, Simon, Matthew D., Yan, Qin, Doench, John G., Wilen, Craig B.
Publicado 2020

Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection

por Wei, Jin, Alfajaro, Mia Madel, DeWeirdt, Peter C., Hanna, Ruth E., Lu-Culligan, William J., Cai, Wesley L., Strine, Madison S., Zhang, Shang-Min, Graziano, Vincent R., Schmitz, Cameron O., Chen, Jennifer S., Mankowski, Madeleine C., Filler, Renata B., Ravindra, Neal G., Gasque, Victor, de Miguel, Fernando J., Patil, Ajinkya, Chen, Huacui, Oguntuyo, Kasopefoluwa Y., Abriola, Laura, Surovtseva, Yulia V., Orchard, Robert C., Lee, Benhur, Lindenbach, Brett D., Politi, Katerina, van Dijk, David, Kadoch, Cigall, Simon, Matthew D., Yan, Qin, Doench, John G., Wilen, Craig B.
Publicado 2021