Mechanistic Insights into the Role of Molecular Chaperones in Protein Misfolding Diseases: From Molecular Recognition to Amyloid Disassembly

por Hervás, Rubén, Oroz, Javier
Publicado 2020

Molecular basis of the interaction of Hsp90 with its co‐chaperone Hop

por Lott, Antonia, Oroz, Javier, Zweckstetter, Markus
Publicado 2020

Dynamic Aha1 co‐chaperone binding to human Hsp90

por Oroz, Javier, Blair, Laura J., Zweckstetter, Markus
Publicado 2019

Do polyproline II helix associations modulate biomolecular condensates?

por Mompeán, Miguel, Oroz, Javier, Laurents, Douglas V.
Publicado 2021

Structural transitions in Orb2 prion-like domain relevant for functional aggregation in memory consolidation

por Oroz, Javier, Félix, Sara S., Cabrita, Eurico J., Laurents, Douglas V.
Publicado 2021

Fused in sarcoma undergoes cold denaturation: Implications for phase separation

por Félix, Sara S., Laurents, Douglas V., Oroz, Javier, Cabrita, Eurico J.
Publicado 2023

Nanomechanics of tip-link cadherins

por Oroz, Javier, Galera-Prat, Albert, Hervás, Rubén, Valbuena, Alejandro, Fernández-Bravo, Débora, Carrión-Vázquez, Mariano
Publicado 2019

Global Structure of the Intrinsically Disordered Protein Tau Emerges from Its Local Structure

por Stelzl, Lukas S., Pietrek, Lisa M., Holla, Andrea, Oroz, Javier, Sikora, Mateusz, Köfinger, Jürgen, Schuler, Benjamin, Zweckstetter, Markus, Hummer, Gerhard
Publicado 2022

Molecular mechanism for the synchronized electrostatic coacervation and co-aggregation of alpha-synuclein and tau

por Gracia, Pablo, Polanco, David, Tarancón-Díez, Jorge, Serra, Ilenia, Bracci, Maruan, Oroz, Javier, Laurents, Douglas V., García, Inés, Cremades, Nunilo
Publicado 2022

Metamorphism in TDP-43 prion-like domain determines chaperone recognition

por Carrasco, Jaime, Antón, Rosa, Valbuena, Alejandro, Pantoja-Uceda, David, Mukhi, Mayur, Hervás, Rubén, Laurents, Douglas V., Gasset, María, Oroz, Javier
Publicado 2023

Common Features at the Start of the Neurodegeneration Cascade

por Hervás, Rubén, Oroz, Javier, Galera-Prat, Albert, Goñi, Oscar, Valbuena, Alejandro, Vera, Andrés M., Gómez-Sicilia, Àngel, Losada-Urzáiz, Fernando, Uversky, Vladimir N., Menéndez, Margarita, Laurents, Douglas V., Bruix, Marta, Carrión-Vázquez, Mariano
Publicado 2012

Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex

por Oroz, Javier, Chang, Bliss J., Wysoczanski, Piotr, Lee, Chung-Tien, Pérez-Lara, Ángel, Chakraborty, Pijush, Hofele, Romina V., Baker, Jeremy D., Blair, Laura J., Biernat, Jacek, Urlaub, Henning, Mandelkow, Eckhard, Dickey, Chad A., Zweckstetter, Markus
Publicado 2018

Mapping Interactions with the Chaperone Network Reveals Factors that Protect Against Tau Aggregation

por Mok, Sue-Ann, Condello, Carlo, Freilich, Rebecca, Gillies, Anne, Arhar, Taylor, Oroz, Javier, Kadavath, Harindranath, Julien, Olivier, Assimon, Victoria A., Rauch, Jennifer N., Dunyak, Bryan M., Lee, Jungsoon, Tsai, Francis T.F., Wilson, Mark R., Zweckstetter, Markus, Dickey, Chad A., Gestwicki, Jason E.
Publicado 2018