Distinct Ubiquitin Binding Modes Exhibited by SH3 Domains: Molecular Determinants and Functional Implications

por Ortega Roldan, Jose L., Casares, Salvador, Ringkjøbing Jensen, Malene, Cárdenes, Nayra, Bravo, Jerónimo, Blackledge, Martin, Azuaga, Ana I., van Nuland, Nico A. J.
Publicado 2013

A Zn(2+)-triggered two-step mechanism of CLIC1 membrane insertion and activation into chloride channels

por Varela, Lorena, Hendry, Alex C., Cassar, Joseph, Martin-Escolano, Ruben, Cantoni, Diego, Ossa, Felipe, Edwards, John C., Abdul-Salam, Vahitha, Ortega-Roldan, Jose L.
Publicado 2022

Structure-based discovery and in vitro validation of inhibitors of chloride intracellular channel 4 protein

por Olotu, Fisayo, Medina-Carmona, Encarnacion, Serrano-Sanchez, Angela, Ossa, Felipe, El-Hamdaoui, Abdelaziz, Bishop, Özlem Tastan, Ortega-Roldan, Jose L., Abdul-Salam, Vahitha B.
Publicado 2022

Discovery and Rational Mutagenesis of Methionine Sulfoxide Reductase Biocatalysts To Expand the Substrate Scope of the Kinetic Resolution of Chiral Sulfoxides

por Anselmi, Silvia, Carvalho, Alexandra T. P., Serrano-Sanchez, Angela, Ortega-Roldan, Jose L., Caswell, Jill, Omar, Iman, Perez-Ortiz, Gustavo, Barry, Sarah M., Moody, Thomas S., Castagnolo, Daniele
Publicado 2023

Establishing the selective phospholipid membrane coordination, permeation and lysis properties for a series of ‘druggable’ supramolecular self-associating antimicrobial amphiphiles...

por Boles, Jessica E., Bennett, Charlotte, Baker, Jennifer, Hilton, Kira L. F., Kotak, Hiral A., Clark, Ewan R., Long, Yifan, White, Lisa J., Lai, Hin Yuk, Hind, Charlotte K., Sutton, J. Mark, Garrett, Michelle D., Cheasty, Anne, Ortega-Roldan, Jose L., Charles, Mark, Haynes, Cally J. E., Hiscock, Jennifer R.
Publicado 2022