Residual Helicity at the Active Site of the Histidine Phosphocarrier, HPr, Modulates Binding Affinity to Its Natural Partners

por Neira, José L., Ortega-Alarcón, David, Rizzuti, Bruno, Palomino-Schätzlein, Martina, Velázquez-Campoy, Adrián, Falcó, Alberto
Publicado 2021

Molecular Context-Dependent Effects Induced by Rett Syndrome-Associated Mutations in MeCP2

por Ortega-Alarcon, David, Claveria-Gimeno, Rafael, Vega, Sonia, Jorge-Torres, Olga C., Esteller, Manel, Abian, Olga, Velazquez-Campoy, Adrian
Publicado 2020

Stabilization Effect of Intrinsically Disordered Regions on Multidomain Proteins: The Case of the Methyl-CpG Protein 2, MeCP2

por Ortega-Alarcon, David, Claveria-Gimeno, Rafael, Vega, Sonia, Jorge-Torres, Olga C., Esteller, Manel, Abian, Olga, Velazquez-Campoy, Adrian
Publicado 2021

Structural stability of SARS-CoV-2 3CLpro and identification of quercetin as an inhibitor by experimental screening

por Abian, Olga, Ortega-Alarcon, David, Jimenez-Alesanco, Ana, Ceballos-Laita, Laura, Vega, Sonia, Reyburn, Hugh T., Rizzuti, Bruno, Velazquez-Campoy, Adrian
Publicado 2020

Sub-Micromolar Inhibition of SARS-CoV-2 3CLpro by Natural Compounds

por Rizzuti, Bruno, Ceballos-Laita, Laura, Ortega-Alarcon, David, Jimenez-Alesanco, Ana, Vega, Sonia, Grande, Fedora, Conforti, Filomena, Abian, Olga, Velazquez-Campoy, Adrian
Publicado 2021

Rutin Is a Low Micromolar Inhibitor of SARS-CoV-2 Main Protease 3CLpro: Implications for Drug Design of Quercetin Analogs

por Rizzuti, Bruno, Grande, Fedora, Conforti, Filomena, Jimenez-Alesanco, Ana, Ceballos-Laita, Laura, Ortega-Alarcon, David, Vega, Sonia, Reyburn, Hugh T., Abian, Olga, Velazquez-Campoy, Adrian
Publicado 2021

MEP pathway products allosterically promote monomerization of deoxy-D-xylulose-5-phosphate synthase to feedback-regulate their supply

por Di, Xueni, Ortega-Alarcon, David, Kakumanu, Ramu, Iglesias-Fernandez, Javier, Diaz, Lucia, Baidoo, Edward E.K., Velazquez-Campoy, Adrian, Rodríguez-Concepción, Manuel, Perez-Gil, Jordi
Publicado 2022

Autochthonous Peruvian Natural Plants as Potential SARS-CoV-2 M(pro) Main Protease Inhibitors

por Peralta-Moreno, Maria Nuria, Anton-Muñoz, Vanessa, Ortega-Alarcon, David, Jimenez-Alesanco, Ana, Vega, Sonia, Abian, Olga, Velazquez-Campoy, Adrian, Thomson, Timothy M., Granadino-Roldán, José Manuel, Machicado, Claudia, Rubio-Martinez, Jaime
Publicado 2023

Discovery of Diverse Natural Products as Inhibitors of SARS-CoV-2 M(pro) Protease through Virtual Screening

por Rubio-Martínez, Jaime, Jiménez-Alesanco, Ana, Ceballos-Laita, Laura, Ortega-Alarcón, David, Vega, Sonia, Calvo, Cristina, Benítez, Cristina, Abian, Olga, Velázquez-Campoy, Adrián, Thomson, Timothy M., Granadino-Roldán, José Manuel, Gómez-Gutiérrez, Patricia, Pérez, Juan J.
Publicado 2021

l-Arginine Improves Solubility and ANTI SARS-CoV-2 Mpro Activity of Rutin but Not the Antiviral Activity in Cells

por Sancineto, Luca, Ostacolo, Carmine, Ortega-Alarcon, David, Jimenez-Alesanco, Ana, Ceballos-Laita, Laura, Vega, Sonia, Abian, Olga, Velazquez-Campoy, Adrian, Moretti, Silvia, Dabrowska, Agnieszka, Botwina, Pawel, Synowiec, Aleksandra, Kula-Pacurar, Anna, Pyrc, Krzysztof, Iraci, Nunzio, Santi, Claudio
Publicado 2021

Development of a Highly Potent Transthyretin Amyloidogenesis Inhibitor: Design, Synthesis, and Evaluation

por Pinheiro, Francisca, Pallarès, Irantzu, Peccati, Francesca, Sánchez-Morales, Adrià, Varejão, Nathalia, Bezerra, Filipa, Ortega-Alarcon, David, Gonzalez, Danilo, Osorio, Marcelo, Navarro, Susanna, Velázquez-Campoy, Adrián, Almeida, Maria Rosário, Reverter, David, Busqué, Félix, Alibés, Ramon, Sodupe, Mariona, Ventura, Salvador
Publicado 2022

Seleno-Functionalization of Quercetin Improves the Non-Covalent Inhibition of M(pro) and Its Antiviral Activity in Cells against SARS-CoV-2

por Mangiavacchi, Francesca, Botwina, Pawel, Menichetti, Elena, Bagnoli, Luana, Rosati, Ornelio, Marini, Francesca, Fonseca, Sérgio F., Abenante, Laura, Alves, Diego, Dabrowska, Agnieszka, Kula-Pacurar, Anna, Ortega-Alarcon, David, Jimenez-Alesanco, Ana, Ceballos-Laita, Laura, Vega, Sonia, Rizzuti, Bruno, Abian, Olga, Lenardão, Eder J., Velazquez-Campoy, Adrian, Pyrc, Krzysztof, Sancineto, Luca, Santi, Claudio
Publicado 2021

Reproducibility and accuracy of microscale thermophoresis in the NanoTemper Monolith: a multi laboratory benchmark study

por López-Méndez, Blanca, Baron, Bruno, Brautigam, Chad A., Jowitt, Thomas A., Knauer, Stefan H., Uebel, Stephan, Williams, Mark A., Sedivy, Arthur, Abian, Olga, Abreu, Celeste, Adamczyk, Malgorzata, Bal, Wojciech, Berger, Sylvie, Buell, Alexander K., Carolis, Carlo, Daviter, Tina, Fish, Alexander, Garcia-Alai, Maria, Guenther, Christian, Hamacek, Josef, Holková, Jitka, Houser, Josef, Johnson, Chris, Kelly, Sharon, Leech, Andrew, Mas, Caroline, Matulis, Daumantas, McLaughlin, Stephen H., Montserret, Roland, Nasreddine, Rouba, Nehmé, Reine, Nguyen, Quyen, Ortega-Alarcón, David, Perez, Kathryn, Pirc, Katja, Piszczek, Grzegorz, Podobnik, Marjetka, Rodrigo, Natalia, Rokov-Plavec, Jasmina, Schaefer, Susanne, Sharpe, Tim, Southall, June, Staunton, David, Tavares, Pedro, Vanek, Ondrej, Weyand, Michael, Wu, Di
Publicado 2021

Correction to: Reproducibility and accuracy of microscale thermophoresis in the NanoTemper Monolith: a multi laboratory benchmark study

por López-Méndez, Blanca, Baron, Bruno, Brautigam, Chad A., Jowitt, Thomas A., Knauer, Stefan H., Uebel, Stephan, Williams, Mark A., Sedivy, Arthur, Abian, Olga, Abreu, Celeste, Adamczyk, Malgorzata, Bal, Wojciech, Berger, Sylvie, Buell, Alexander K., Carolis, Carlo, Daviter, Tina, Fish, Alexander, Garcia-Alai, Maria, Guenther, Christian, Hamacek, Josef, Holková, Jitka, Houser, Josef, Johnson, Chris, Kelly, Sharon, Leech, Andrew, Mas, Caroline, Matulis, Daumantas, McLaughlin, Stephen H., Montserret, Roland, Nasreddine, Rouba, Nehmé, Reine, Nguyen, Quyen, Ortega-Alarcón, David, Perez, Kathryn, Pirc, Katja, Piszczek, Grzegorz, Podobnik, Marjetka, Rodrigo, Natalia, Rokov-Plavec, Jasmina, Schaefer, Susanne, Sharpe, Tim, Southall, June, Staunton, David, Tavares, Pedro, Vanek, Ondrej, Weyand, Michael, Wu, Di
Publicado 2021