Fosfomycin as a potential therapy for the treatment of systemic infections: a population pharmacokinetic model to simulate multiple dosing regimens

por Ortiz Zacarías, Natalia V., Dijkmans, Anneke C., Burggraaf, Jacobus, Mouton, Johan W., Wilms, Erik B., van Nieuwkoop, Cees, Touw, Daan J., Kamerling, Ingrid M. C., Stevens, Jasper
Publicado 2018

Synthesis and Pharmacological Evaluation of Triazolopyrimidinone Derivatives as Noncompetitive, Intracellular Antagonists for CC Chemokine Receptors 2 and 5

por Ortiz Zacarías, Natalia V., van Veldhoven, Jacobus P. D., den Hollander, Lisa S., Dogan, Burak, Openy, Joseph, Hsiao, Ya-Yun, Lenselink, Eelke B., Heitman, Laura H., IJzerman, Adriaan P.
Publicado 2019

Development of the First Potential Nonpeptidic Positron Emission Tomography Tracer for the Imaging of CCR2 Receptors

por Wagner, Stefan, de Moura Gatti, Fernando, Silva, Daniel G., Ortiz Zacarias, Natalia V., Zweemer, Annelien J. M., Hermann, Sven, De Maria, Monica, Koch, Michael, Weiss, Christina, Schepmann, Dirk, Heitman, Laura H., Tschammer, Nuska, Kopka, Klaus, Junker, Anna
Publicado 2020

Design and Characterization of an Intracellular Covalent Ligand for CC Chemokine Receptor 2

por Ortiz Zacarías, Natalia V., Chahal, Kirti K., Šimková, Tereza, van der Horst, Cas, Zheng, Yi, Inoue, Asuka, Theunissen, Emy, Mallee, Lloyd, van der Es, Daan, Louvel, Julien, IJzerman, Adriaan P., Handel, Tracy M., Kufareva, Irina, Heitman, Laura H.
Publicado 2021

Pyrrolone Derivatives as Intracellular Allosteric Modulators for Chemokine Receptors: Selective and Dual-Targeting Inhibitors of CC Chemokine Receptors 1 and 2

por Ortiz Zacarías, Natalia V., van Veldhoven, Jacobus P. D., Portner, Laura, van Spronsen, Eric, Ullo, Salviana, Veenhuizen, Margo, van der Velden, Wijnand J. C., Zweemer, Annelien J. M., Kreekel, Roy M., Oenema, Kenny, Lenselink, Eelke B., Heitman, Laura H., IJzerman, Adriaan P.
Publicado 2018

A novel CCR2 antagonist inhibits atherogenesis in apoE deficient mice by achieving high receptor occupancy

por Bot, Ilze, Ortiz Zacarías, Natalia V., de Witte, Wilhelmus E. A., de Vries, Henk, van Santbrink, Peter J., van der Velden, Daniël, Kröner, Mara J., van der Berg, Dirk-Jan, Stamos, Dean, de Lange, Elizabeth C. M., Kuiper, Johan, IJzerman, Adriaan P., Heitman, Laura H.
Publicado 2017

Structure of CC Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists

por Zheng, Yi, Qin, Ling, Ortiz Zacarías, Natalia V., de Vries, Henk, Han, Gye Won, Gustavsson, Martin, Dabros, Marta, Zhao, Chunxia, Cherney, Robert J., Carter, Percy, Stamos, Dean, Abagyan, Ruben, Cherezov, Vadim, Stevens, Raymond C., IJzerman, Adriaan P., Heitman, Laura H., Tebben, Andrew, Kufareva, Irina, Handel, Tracy M.
Publicado 2016