X-Ray Crystal Structure of the Ancestral 3-Ketosteroid Receptor–Progesterone–Mifepristone Complex Shows Mifepristone Bound at the Coactivator Binding Interface

por Colucci, Jennifer K., Ortlund, Eric A.
Publicado 2013

The structural basis of direct glucocorticoid-mediated transrepression

por Hudson, William H., Youn, Christine, Ortlund, Eric A.
Publicado 2012

Crystal Structure of the Mineralocorticoid Receptor DNA Binding Domain in Complex with DNA

por Hudson, William H., Youn, Christine, Ortlund, Eric A.
Publicado 2014

The first crystal structure of a DNA-free nuclear receptor DNA binding domain sheds light on DNA-driven allostery in the glucocorticoid receptor

por Frank, Filipp, Okafor, C. Denise, Ortlund, Eric A.
Publicado 2018

An epistatic ratchet constrains the direction of glucocorticoid receptor evolution

por Bridgham, Jamie T., Ortlund, Eric A., Thornton, Joseph W.
Publicado 2009

Mechanisms for the Evolution of a Derived Function in the Ancestral Glucocorticoid Receptor

por Carroll, Sean Michael, Ortlund, Eric A., Thornton, Joseph W.
Publicado 2011

Vestigialization of an Allosteric Switch: Genetic and Structural Mechanisms for the Evolution of Constitutive Activity in a Steroid Hormone Receptor

por Bridgham, Jamie T., Keay, June, Ortlund, Eric A., Thornton, Joseph W.
Publicado 2014

The nuclear receptor LRH‐1 discriminates between ligands using distinct allosteric signaling circuits

por Mays, Suzanne G., Hercules, David, Ortlund, Eric A., Okafor, C. Denise
Publicado 2023

Structural basis for glucocorticoid receptor recognition of both unmodified and methylated binding sites, precursors of a modern recognition element

por Liu, Xu, Weikum, Emily R, Tilo, Desiree, Vinson, Charles, Ortlund, Eric A
Publicado 2021

Structural characterization of life-extending Caenorhabditis elegans Lipid Binding Protein 8

por Tillman, Matthew C., Khadka, Manoj, Duffy, Jonathon, Wang, Meng C., Ortlund, Eric A.
Publicado 2019

African American Women with Cardiometabolic Complications of Pregnancy Have Decreased Serum Abundance of Specialized Pro-Resolving Lipid Mediators and Endocannabinoids

por Maner-Smith, Kristal M., Ferranti, Erin, Dunlop, Anne, Corwin, Elizabeth, Ortlund, Eric A.
Publicado 2022

Age- and Diet-Dependent Changes in Hepatic Lipidomic Profiles of Phospholipids in Male Mice: Age Acceleration in Cyp2b-Null Mice

por Heintz, Melissa M., Kumar, Ramiya, Maner-Smith, Kristal M., Ortlund, Eric A., Baldwin, William S.
Publicado 2022

Evolution of Minimal Specificity and Promiscuity in Steroid Hormone Receptors

por Eick, Geeta N., Colucci, Jennifer K., Harms, Michael J., Ortlund, Eric A., Thornton, Joseph W.
Publicado 2012

Identification of a lipid scrambling domain in ANO6/TMEM16F

por Yu, Kuai, Whitlock, Jarred M, Lee, Kyleen, Ortlund, Eric A, Yuan Cui, Yuan, Hartzell, H Criss
Publicado 2015

Enantiomer-specific activities of an LRH-1 and SF-1 dual agonist

por Mays, Suzanne G., Stec, Józef, Liu, Xu, D’Agostino, Emma H., Whitby, Richard J., Ortlund, Eric A.
Publicado 2020

Human CYP2B6 produces oxylipins from polyunsaturated fatty acids and reduces diet-induced obesity

por Heintz, Melissa M., Eccles, Jazmine A., Olack, Emily M., Maner-Smith, Kristal M., Ortlund, Eric A., Baldwin, William S.
Publicado 2022

Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes

por Weikum, Emily R., de Vera, Ian Mitchelle S., Nwachukwu, Jerome C., Hudson, William H., Nettles, Kendall W., Kojetin, Douglas J., Ortlund, Eric A.
Publicado 2017

Antidiabetic actions of a phosphatidylcholine ligand for nuclear receptor LRH-1

por Lee, Jae Man, Lee, Yoon Kwang, Mamrosh, Jennifer L., Busby, Scott A., Griffin, Patrick R., Pathak, Manish C., Ortlund, Eric A., Moore, David D.
Publicado 2011

The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells

por Moody, Jasmine C., Qadota, Hiroshi, Reedy, April R., Okafor, C. Denise, Shanmugan, Niveda, Matsunaga, Yohei, Christian, Courtney J., Ortlund, Eric A., Benian, Guy M.
Publicado 2020

Protein Evolution by Molecular Tinkering: Diversification of the Nuclear Receptor Superfamily from a Ligand-Dependent Ancestor

por Bridgham, Jamie T., Eick, Geeta N., Larroux, Claire, Deshpande, Kirti, Harms, Michael J., Gauthier, Marie E. A., Ortlund, Eric A., Degnan, Bernard M., Thornton, Joseph W.
Publicado 2010