Cell cycle regulators control mesoderm specification in human pluripotent stem cells

por Yiangou, Loukia, Grandy, Rodrigo A., Osnato, Anna, Ortmann, Daniel, Sinha, Sanjay, Vallier, Ludovic
Publicado 2019

Inducible and Deterministic Forward Programming of Human Pluripotent Stem Cells into Neurons, Skeletal Myocytes, and Oligodendrocytes

por Pawlowski, Matthias, Ortmann, Daniel, Bertero, Alessandro, Tavares, Joana M., Pedersen, Roger A., Vallier, Ludovic, Kotter, Mark R.N.
Publicado 2017

Analysis of endothelial-to-haematopoietic transition at the single cell level identifies cell cycle regulation as a driver of differentiation

por Canu, Giovanni, Athanasiadis, Emmanouil, Grandy, Rodrigo A., Garcia-Bernardo, Jose, Strzelecka, Paulina M., Vallier, Ludovic, Ortmann, Daniel, Cvejic, Ana
Publicado 2020

Epigenetic and transcriptional regulations prime cell fate before division during human pluripotent stem cell differentiation

por Madrigal, Pedro, Deng, Siwei, Feng, Yuliang, Militi, Stefania, Goh, Kim Jee, Nibhani, Reshma, Grandy, Rodrigo, Osnato, Anna, Ortmann, Daniel, Brown, Stephanie, Pauklin, Siim
Publicado 2023

Brachyury and SMAD signalling collaboratively orchestrate distinct mesoderm and endoderm gene regulatory networks in differentiating human embryonic stem cells

por Faial, Tiago, Bernardo, Andreia S., Mendjan, Sasha, Diamanti, Evangelia, Ortmann, Daniel, Gentsch, George E., Mascetti, Victoria L., Trotter, Matthew W. B., Smith, James C., Pedersen, Roger A.
Publicado 2015

BRACHYURY and CDX2 Mediate BMP-Induced Differentiation of Human and Mouse Pluripotent Stem Cells into Embryonic and Extraembryonic Lineages

por Bernardo, Andreia S., Faial, Tiago, Gardner, Lucy, Niakan, Kathy K., Ortmann, Daniel, Senner, Claire E., Callery, Elizabeth M., Trotter, Matthew W., Hemberger, Myriam, Smith, James C., Bardwell, Lee, Moffett, Ashley, Pedersen, Roger A.
Publicado 2011

Single-Cell Sequencing of Developing Human Gut Reveals Transcriptional Links to Childhood Crohn’s Disease

por Elmentaite, Rasa, Ross, Alexander D.B., Roberts, Kenny, James, Kylie R., Ortmann, Daniel, Gomes, Tomás, Nayak, Komal, Tuck, Liz, Pritchard, Sophie, Bayraktar, Omer Ali, Heuschkel, Robert, Vallier, Ludovic, Teichmann, Sarah A., Zilbauer, Matthias
Publicado 2020

TGFβ signalling is required to maintain pluripotency of human naïve pluripotent stem cells

por Osnato, Anna, Brown, Stephanie, Krueger, Christel, Andrews, Simon, Collier, Amanda J, Nakanoh, Shota, Quiroga Londoño, Mariana, Wesley, Brandon T, Muraro, Daniele, Brumm, A Sophie, Niakan, Kathy K, Vallier, Ludovic, Ortmann, Daniel, Rugg-Gunn, Peter J
Publicado 2021

Method to Synchronize Cell Cycle of Human Pluripotent Stem Cells without Affecting Their Fundamental Characteristics

por Yiangou, Loukia, Grandy, Rodrigo A., Morell, Carola M., Tomaz, Rute A., Osnato, Anna, Kadiwala, Juned, Muraro, Daniele, Garcia-Bernardo, Jose, Nakanoh, Shota, Bernard, William G., Ortmann, Daniel, McCarthy, Davis J., Simonic, Ingrid, Sinha, Sanjay, Vallier, Ludovic
Publicado 2018

The SMAD2/3 interactome reveals that TGFβ controls m(6)A mRNA methylation in pluripotency

por Bertero, Alessandro, Brown, Stephanie, Madrigal, Pedro, Osnato, Anna, Ortmann, Daniel, Yiangou, Loukia, Kadiwala, Juned, Hubner, Nina C., de los Mozos, Igor Ruiz, Sadee, Christoph, Lenaerts, An-Sofie, Nakanoh, Shota, Grandy, Rodrigo, Farnell, Edward, Ule, Jernej, Stunnenberg, Hendrik G., Mendjan, Sasha, Vallier, Ludovic
Publicado 2018

Generation of functional hepatocytes by forward programming with nuclear receptors

por Tomaz, Rute A, Zacharis, Ekaterini D, Bachinger, Fabian, Wurmser, Annabelle, Yamamoto, Daniel, Petrus-Reurer, Sandra, Morell, Carola M, Dziedzicka, Dominika, Wesley, Brandon T, Geti, Imbisaat, Segeritz, Charis-Patricia, de Brito, Miguel C, Chhatriwala, Mariya, Ortmann, Daniel, Saeb-Parsy, Kourosh, Vallier, Ludovic
Publicado 2022

Human axial progenitors generate trunk neural crest cells in vitro

por Frith, Thomas JR, Granata, Ilaria, Wind, Matthew, Stout, Erin, Thompson, Oliver, Neumann, Katrin, Stavish, Dylan, Heath, Paul R, Ortmann, Daniel, Hackland, James OS, Anastassiadis, Konstantinos, Gouti, Mina, Briscoe, James, Wilson, Valerie, Johnson, Stuart L, Placzek, Marysia, Guarracino, Mario R, Andrews, Peter W, Tsakiridis, Anestis
Publicado 2018

Optimized inducible shRNA and CRISPR/Cas9 platforms for in vitro studies of human development using hPSCs

por Bertero, Alessandro, Pawlowski, Matthias, Ortmann, Daniel, Snijders, Kirsten, Yiangou, Loukia, Cardoso de Brito, Miguel, Brown, Stephanie, Bernard, William G., Cooper, James D., Giacomelli, Elisa, Gambardella, Laure, Hannan, Nicholas R. F., Iyer, Dharini, Sampaziotis, Fotios, Serrano, Felipe, Zonneveld, Mariëlle C. F., Sinha, Sanjay, Kotter, Mark, Vallier, Ludovic
Publicado 2016

Naive Pluripotent Stem Cells Exhibit Phenotypic Variability that Is Driven by Genetic Variation

por Ortmann, Daniel, Brown, Stephanie, Czechanski, Anne, Aydin, Selcan, Muraro, Daniele, Huang, Yuanhua, Tomaz, Rute A., Osnato, Anna, Canu, Giovanni, Wesley, Brandon T., Skelly, Daniel A., Stegle, Oliver, Choi, Ted, Churchill, Gary A., Baker, Christopher L., Rugg-Gunn, Peter J., Munger, Steven C., Reinholdt, Laura G., Vallier, Ludovic
Publicado 2020

Retinoic acid signaling modulation guides in vitro specification of human heart field-specific progenitor pools

por Zawada, Dorota, Kornherr, Jessica, Meier, Anna B., Santamaria, Gianluca, Dorn, Tatjana, Nowak-Imialek, Monika, Ortmann, Daniel, Zhang, Fangfang, Lachmann, Mark, Dreßen, Martina, Ortiz, Mariaestela, Mascetti, Victoria L., Harmer, Stephen C., Nobles, Muriel, Tinker, Andrew, De Angelis, Maria Teresa, Pedersen, Roger A., Grote, Phillip, Laugwitz, Karl-Ludwig, Moretti, Alessandra, Goedel, Alexander
Publicado 2023