Identification of New Natural DNA G-Quadruplex Binders Selected by a Structure-Based Virtual Screening Approach

por Artese, Anna, Costa, Giosuè, Ortuso, Francesco, Parrotta, Lucia, Alcaro, Stefano
Publicado 2013

N-myristoylation determines dual targeting of mammalian NADH-cytochrome b(5) reductase to ER and mitochondrial outer membranes by a mechanism of kinetic partitioning

por Colombo, Sara, Longhi, Renato, Alcaro, Stefano, Ortuso, Francesco, Sprocati, Teresa, Flora, Adriano, Borgese, Nica
Publicado 2005

Molecular Modeling and Experimental Evaluation of Non-Chiral Components of Bergamot Essential Oil with Inhibitory Activity against Human Monoamine Oxidases

por Catalano, Raffaella, Procopio, Francesca, Chavarria, Daniel, Benfeito, Sofia, Alcaro, Stefano, Borges, Fernanda, Ortuso, Francesco
Publicado 2022

Ligand binding to telomeric G-quadruplex DNA investigated by funnel-metadynamics simulations

por Moraca, Federica, Amato, Jussara, Ortuso, Francesco, Artese, Anna, Pagano, Bruno, Novellino, Ettore, Alcaro, Stefano, Parrinello, Michele, Limongelli, Vittorio
Publicado 2017

Structure-Based Virtual Screening of Novel Natural Alkaloid Derivatives as Potential Binders of h-telo and c-myc DNA G-Quadruplex Conformations

por Rocca, Roberta, Moraca, Federica, Costa, Giosuè, Alcaro, Stefano, Distinto, Simona, Maccioni, Elias, Ortuso, Francesco, Artese, Anna, Parrotta, Lucia
Publicado 2014

Chemoinformatic Database Building and in Silico Hit-Identification of Potential Multi-Targeting Bioactive Compounds Extracted from Mushroom Species

por Maruca, Annalisa, Moraca, Federica, Rocca, Roberta, Molisani, Fulvia, Alcaro, Francesca, Gidaro, Maria Concetta, Alcaro, Stefano, Costa, Giosuè, Ortuso, Francesco
Publicado 2017

Folding intermediate states of the parallel human telomeric G-quadruplex DNA explored using Well-Tempered Metadynamics

por Rocca, Roberta, Palazzesi, Ferruccio, Amato, Jussara, Costa, Giosuè, Ortuso, Francesco, Pagano, Bruno, Randazzo, Antonio, Novellino, Ettore, Alcaro, Stefano, Moraca, Federica, Artese, Anna
Publicado 2020

Natural Products Extracted from Fungal Species as New Potential Anti-Cancer Drugs: A Structure-Based Drug Repurposing Approach Targeting HDAC7

por Maruca, Annalisa, Rocca, Roberta, Catalano, Raffaella, Mesiti, Francesco, Costa, Giosuè, Lanzillotta, Delia, Salatino, Alessandro, Ortuso, Francesco, Trapasso, Francesco, Alcaro, Stefano, Artese, Anna
Publicado 2020

The Mu.Ta.Lig. Chemotheca: A Community-Populated Molecular Database for Multi-Target Ligands Identification and Compound-Repurposing

por Ortuso, Francesco, Bagetta, Donatella, Maruca, Annalisa, Talarico, Carmine, Bolognesi, Maria L., Haider, Norbert, Borges, Fernanda, Bryant, Sharon, Langer, Thierry, Senderowitz, Hanoch, Alcaro, Stefano
Publicado 2018

4-(3-Nitrophenyl)thiazol-2-ylhydrazone derivatives as antioxidants and selective hMAO-B inhibitors: synthesis, biological activity and computational analysis

por Secci, Daniela, Carradori, Simone, Petzer, Anél, Guglielmi, Paolo, D’Ascenzio, Melissa, Chimenti, Paola, Bagetta, Donatella, Alcaro, Stefano, Zengin, Gokhan, Petzer, Jacobus P., Ortuso, Francesco
Publicado 2019

Multi-Targeting Bioactive Compounds Extracted from Essential Oils as Kinase Inhibitors

por Maruca, Annalisa, Lanzillotta, Delia, Rocca, Roberta, Lupia, Antonio, Costa, Giosuè, Catalano, Raffaella, Moraca, Federica, Gaudio, Eugenio, Ortuso, Francesco, Artese, Anna, Trapasso, Francesco, Alcaro, Stefano
Publicado 2020

Selective inhibition of carbonic anhydrase IX and XII by coumarin and psoralen derivatives

por Meleddu, Rita, Deplano, Serenella, Maccioni, Elias, Ortuso, Francesco, Cottiglia, Filippo, Secci, Daniela, Onali, Alessia, Sanna, Erica, Angeli, Andrea, Angius, Rossella, Alcaro, Stefano, Supuran, Claudiu T., Distinto, Simona
Publicado 2021

Design, Synthesis, and Evaluation of New Tripeptides as COX-2 Inhibitors

por Vernieri, Ermelinda, Gomez-Monterrey, Isabel, Milite, Ciro, Grieco, Paolo, Musella, Simona, Bertamino, Alessia, Scognamiglio, Ilaria, Alcaro, Stefano, Artese, Anna, Ortuso, Francesco, Novellino, Ettore, Sala, Marina, Campiglia, Pietro
Publicado 2013

Exploring new structural features of the 4-[(3-methyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzenesulphonamide scaffold for the inhibition of human carbonic anhydrases

por Distinto, Simona, Meleddu, Rita, Ortuso, Francesco, Cottiglia, Filippo, Deplano, Serenella, Sequeira, Lisa, Melis, Claudia, Fois, Benedetta, Angeli, Andrea, Capasso, Clemente, Angius, Rossella, Alcaro, Stefano, Supuran, Claudiu T., Maccioni, Elias
Publicado 2019

Benzo[b]tiophen-3-ol derivatives as effective inhibitors of human monoamine oxidase: design, synthesis, and biological activity

por Guglielmi, Paolo, Secci, Daniela, Petzer, Anél, Bagetta, Donatella, Chimenti, Paola, Rotondi, Giulia, Ferrante, Claudio, Recinella, Lucia, Leone, Sheila, Alcaro, Stefano, Zengin, Gokhan, Petzer, Jacobus P., Ortuso, Francesco, Carradori, Simone
Publicado 2019

A Fhit-mimetic peptide suppresses annexin A4-mediated chemoresistance to paclitaxel in lung cancer cells

por Gaudio, Eugenio, Paduano, Francesco, Ngankeu, Apollinaire, Ortuso, Francesco, Lovat, Francesca, Pinton, Sandra, D'Agostino, Sabrina, Zanesi, Nicola, Aqeilan, Rami I., Campiglia, Pietro, Novellino, Ettore, Alcaro, Stefano, Croce, Carlo M., Trapasso, Francesco
Publicado 2016

Ferritin Heavy Chain Binds Peroxiredoxin 6 and Inhibits Cell Proliferation and Migration

por Di Sanzo, Maddalena, Cozzolino, Flora, Battaglia, Anna Martina, Aversa, Ilenia, Monaco, Vittoria, Sacco, Alessandro, Biamonte, Flavia, Palmieri, Camillo, Procopio, Francesca, Santamaria, Gianluca, Ortuso, Francesco, Pucci, Piero, Monti, Maria, Faniello, Maria Concetta
Publicado 2022

Exploring New Scaffolds for the Dual Inhibition of HIV-1 RT Polymerase and Ribonuclease Associated Functions

por Meleddu, Rita, Corona, Angela, Distinto, Simona, Cottiglia, Filippo, Deplano, Serenella, Sequeira, Lisa, Secci, Daniela, Onali, Alessia, Sanna, Erica, Esposito, Francesca, Cirone, Italo, Ortuso, Francesco, Alcaro, Stefano, Tramontano, Enzo, Mátyus, Péter, Maccioni, Elias
Publicado 2021

Chromene Derivatives as Selective TERRA G-Quadruplex RNA Binders with Antiproliferative Properties

por Rocca, Roberta, Scionti, Francesca, Nadai, Matteo, Moraca, Federica, Maruca, Annalisa, Costa, Giosuè, Catalano, Raffaella, Juli, Giada, Di Martino, Maria Teresa, Ortuso, Francesco, Alcaro, Stefano, Tagliaferri, Pierosandro, Tassone, Pierfrancesco, Richter, Sara N., Artese, Anna
Publicado 2022

Fhit Delocalizes Annexin A4 from Plasma Membrane to Cytosol and Sensitizes Lung Cancer Cells to Paclitaxel

por Gaudio, Eugenio, Paduano, Francesco, Spizzo, Riccardo, Ngankeu, Apollinaire, Zanesi, Nicola, Gaspari, Marco, Ortuso, Francesco, Lovat, Francesca, Rock, Jonathan, Hill, Grace A., Kaou, Mohamed, Cuda, Giovanni, Aqeilan, Rami I., Alcaro, Stefano, Croce, Carlo M., Trapasso, Francesco
Publicado 2013