Differentiation of immortalized human multi-lineage progenitor to alveolar type 2-like cells: angiotensin-converting enzyme 2 expression and binding of severe acute respiratory syn...

por Collins, Daniel P., Osborn, Mark J., Steer, Clifford J.
Publicado 2021

Incorporation of Immune Checkpoint Blockade into Chimeric Antigen Receptor T Cells (CAR-Ts): Combination or Built-In CAR-T

por Yoon, Dok Hyun, Osborn, Mark J., Tolar, Jakub, Kim, Chong Jai
Publicado 2018

Revertant Mosaicism in Epidermolysis Bullosa

por Meyer-Mueller, Cameron, Osborn, Mark J., Tolar, Jakub, Boull, Christina, Ebens, Christen L.
Publicado 2022

Genome-wide Specificity of Highly Efficient TALENs and CRISPR/Cas9 for T Cell Receptor Modification

por Knipping, Friederike, Osborn, Mark J., Petri, Karl, Tolar, Jakub, Glimm, Hanno, von Kalle, Christof, Schmidt, Manfred, Gabriel, Richard
Publicado 2017

Engineering Human Cells Expressing CRISPR/Cas9-Synergistic Activation Mediators for Recombinant Protein Production

por Feser, Colby J., Williams, James M., Lammers, Daniel T., Bingham, Jason R., Eckert, Matthew J., Tolar, Jakub, Osborn, Mark J.
Publicado 2023

CRISPR/Cas9-Mediated Correction of the FANCD1 Gene in Primary Patient Cells

por Skvarova Kramarzova, Karolina, Osborn, Mark J., Webber, Beau R., DeFeo, Anthony P., McElroy, Amber N., Kim, Chong Jai, Tolar, Jakub
Publicado 2017

Engineering CRISPR/Cas9 for Multiplexed Recombinant Coagulation Factor Production

por Feser, Colby J., Lees, Christopher J., Lammers, Daniel T., Riddle, Megan J., Bingham, Jason R., Eckert, Matthew J., Tolar, Jakub, Osborn, Mark J.
Publicado 2022

Human CD19-specific switchable CAR T-cells are efficacious as constitutively active CAR T-cells but cause less morbidity in a mouse model of human CD19(+) malignancy

por Pennell, Christopher A, Campbell, Heather, Storlie, Meghan D, Bolivar-Wagers, Sara, Osborn, Mark J, Refaeli, Yosef, Jensen, Michael, Viaud, Sophie, Young, Travis S, Blazar, Bruce R
Publicado 2022

CRISPR/Cas9-Based Lateral Flow and Fluorescence Diagnostics

por Osborn, Mark J., Bhardwaj, Akshay, Bingea, Samuel P., Knipping, Friederike, Feser, Colby J., Lees, Christopher J., Collins, Daniel P., Steer, Clifford J., Blazar, Bruce R., Tolar, Jakub
Publicado 2021

Targeting G with TAL Effectors: A Comparison of Activities of TALENs Constructed with NN and NK Repeat Variable Di-Residues

por Christian, Michelle L., Demorest, Zachary L., Starker, Colby G., Osborn, Mark J., Nyquist, Michael D., Zhang, Yong, Carlson, Daniel F., Bradley, Philip, Bogdanove, Adam J., Voytas, Daniel F.
Publicado 2012

Keratinocytes from Induced Pluripotent Stem Cells in Junctional Epidermolysis Bullosa

por Tolar, Jakub, Xia, Lily, Lees, Chris J, Riddle, Megan, McElroy, Amber, Keene, Douglas R, Lund, Troy C, Osborn, Mark J, Marinkovich, M. Peter, Blazar, Bruce R, Wagner, John E
Publicado 2012

Patient-specific naturally gene-reverted induced pluripotent stem cells in recessive dystrophic epidermolysis bullosa

por Tolar, Jakub, McGrath, John A., Xia, Lily, Riddle, Megan, Lees, Chris J., Eide, Cindy, Keene, Douglas R., Liu, Lu, Osborn, Mark J., Lund, Troy C., Blazar, Bruce R., Wagner, John E.
Publicado 2013

Enhanced prime editing systems by manipulating cellular determinants of editing outcomes

por Chen, Peter J., Hussmann, Jeffrey A., Yan, Jun, Knipping, Friederike, Ravisankar, Purnima, Chen, Pin-Fang, Chen, Cidi, Nelson, James W., Newby, Gregory A., Sahin, Mustafa, Osborn, Mark J., Weissman, Jonathan S., Adamson, Britt, Liu, David R.
Publicado 2021

Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins

por Banskota, Samagya, Raguram, Aditya, Suh, Susie, Du, Samuel W., Davis, Jessie R., Choi, Elliot H., Wang, Xiao, Nielsen, Sarah C., Newby, Gregory A., Randolph, Peyton B., Osborn, Mark J., Musunuru, Kiran, Palczewski, Krzysztof, Liu, David R.
Publicado 2022

Evolution of an adenine base editor into a small, efficient cytosine base editor with low off-target activity

por Neugebauer, Monica E., Hsu, Alvin, Arbab, Mandana, Krasnow, Nicholas A., McElroy, Amber N., Pandey, Smriti, Doman, Jordan L., Huang, Tony P., Raguram, Aditya, Banskota, Samagya, Newby, Gregory A., Tolar, Jakub, Osborn, Mark J., Liu, David R.
Publicado 2022

CRISPR/Cas9-Based Cellular Engineering for Targeted Gene Overexpression

por Osborn, Mark J., Lees, Christopher J., McElroy, Amber N., Merkel, Sarah C., Eide, Cindy R., Mathews, Wendy, Feser, Colby J., Tschann, Madison, McElmury, Ron T., Webber, Beau R., Kim, Chong Jai, Blazar, Bruce R., Tolar, Jakub
Publicado 2018

Prokaryotic soluble expression and purification of bioactive human fibroblast growth factor 21 using maltose-binding protein

por Nguyen, Anh Ngoc, Song, Jung-A, Nguyen, Minh Tan, Do, Bich Hang, Kwon, Grace G., Park, Sang Su, Yoo, Jiwon, Jang, Jaepyeong, Jin, Jonghwa, Osborn, Mark J., Jang, Yeon Jin, Thi Vu, Thu Trang, Oh, Heung-Bum, Choe, Han
Publicado 2017

Granulocyte colony-stimulating factor (GCSF) fused with Fc Domain produced from E. coli is less effective than Polyethylene Glycol-conjugated GCSF

por Do, Bich Hang, Kang, Hyo Jeong, Song, Jung-A, Nguyen, Minh Tan, Park, Sangsu, Yoo, Jiwon, Nguyen, Anh Ngoc, Kwon, Grace G., Jang, Jaepyeong, Jang, Mihee, Lee, Sunju, So, Seoungjun, Sim, Seongrak, Lee, Kyung Jin, Osborn, Mark J., Choe, Han
Publicado 2017

Rapid generation of Col7a1(−/−) mouse model of recessive dystrophic epidermolysis bullosa and partial rescue via immunosuppressive dermal mesenchymal stem cells

por Webber, Beau R., O’Connor, Kyle T., McElmurry, Ron T., Durgin, Elise N., Eide, Cindy, Lees, Christopher J., Riddle, Megan J., Mathews, Wendy, Frank, Natasha Y., Kluth, Mark A., Ganss, Christoph, Moriarity, Branden S., Frank, Markus H., Osborn, Mark J., Tolar, Jakub
Publicado 2017

CRISPR/Cas9-based genetic correction for recessive dystrophic epidermolysis bullosa

por Webber, Beau R, Osborn, Mark J, McElroy, Amber N, Twaroski, Kirk, Lonetree, Cara-lin, DeFeo, Anthony P, Xia, Lily, Eide, Cindy, Lees, Christopher J, McElmurry, Ron T, Riddle, Megan J, Kim, Chong Jai, Patel, Dharmeshkumar D, Blazar, Bruce R, Tolar, Jakub
Publicado 2016