Gain-of-function mutant p53 promotes the oncogenic potential of head and neck squamous cell carcinoma cells by targeting the transcription factors FOXO3a and FOXM1

por Tanaka, Noriaki, Zhao, Mei, Tang, Lin, Patel, Ameeta A., Xi, Qing, Van, Hieu T., Takahashi, Hideaki, Osman, Abdullah A., Zhang, Jiexin, Wang, Jing, Myers, Jeffrey N., Zhou, Ge
Publicado 2017

Local Anti–PD-1 Delivery Prevents Progression of Premalignant Lesions in a 4NQO-Oral Carcinogenesis Mouse Model

por Shi, Yewen, Xie, Tong-xin, Leach, David G., Wang, Bingbing, Young, Simon, Osman, Abdullah A., Sikora, Andrew G., Ren, Xiaoyong, Hartgerink, Jeffrey D., Myers, Jeffrey N., Rangel, Roberto
Publicado 2021

TP53 gain-of-function mutation modulates the immunosuppressive microenvironment in non-HPV-associated oral squamous cell carcinoma

por Shi, Yewen, Ren, Xiaoyong, Cao, Shaolong, Chen, Xi, Yuan, Bo, Brasil da Costa, Fabio Henrique, Rodriguez Rosario, Alanis E, Corona, Arnoldo, Michikawa, Chieko, Veeramachaneni, Ratna, Osman, Abdullah A, Xie, Tongxin, Wang, Wenyi, Sikora, Andrew G, Myers, Jeffrey N, Rangel, Roberto
Publicado 2023

Mutant p53 drives an immune cold tumor immune microenvironment in oral squamous cell carcinoma

por Shi, Yewen, Xie, Tongxin, Wang, Bingbing, Wang, Rong, Cai, Yu, Yuan, Bo, Gleber-Netto, Frederico O., Tian, Xiangjun, Rodriguez-Rosario, Alanis E., Osman, Abdullah A., Wang, Jing, Pickering, Curtis R., Ren, Xiaoyong, Sikora, Andrew G., Myers, Jeffrey N., Rangel, Roberto
Publicado 2022

Dysregulation and Epigenetic Reprogramming of NRF2 Signaling Axis Promote Acquisition of Cisplatin Resistance and Metastasis in Head and Neck Squamous Cell Carcinoma

por Osman, Abdullah A., Arslan, Emre, Bartels, Mason, Michikawa, Chieko, Lindemann, Antje, Tomczak, Katarzyna, Yu, Wangjie, Sandulache, Vlad, Ma, Wencai, Shen, Li, Wang, Jing, Singh, Anand K., Frederick, Mitchell J., Spencer, Nakia D., Kovacs, Jeffery, Heffernan, Timothy, Symmans, William F., Rai, Kunal, Myers, Jeffrey N.
Publicado 2023

Evolutionary Action Score of TP53 Analysis in Pathologically High-Risk Human Papillomavirus-Negative Head and Neck Cancer From a Phase 2 Clinical Trial: NRG Oncology Radiation Ther...

por Michikawa, Chieko, Torres-Saavedra, Pedro A., Silver, Natalie L., Harari, Paul M., Kies, Merrill S., Rosenthal, David I., Le, Quynh-Thu, Jordan, Richard C., Duose, Dzifa Y., Mallampati, Saradhi, Trivedi, Sanchit, Luthra, Rajyalakshmi, Wistuba, Ignacio I., Osman, Abdullah A., Lichtarge, Olivier, Foote, Robert L., Parvathaneni, Upendra, Hayes, D. Neil, Pickering, Curtis R., Myers, Jeffrey N.
Publicado 2022