New tools for experimental diabetes research: Cellular reprogramming and genome editing

por Otonkoski, Timo
Publicado 2016

Stem Cell Based Models in Congenital Hyperinsulinism – Perspective on Practicalities and Possibilities

por Lithovius, Väinö, Otonkoski, Timo
Publicado 2022

Maturation of beta cells: lessons from in vivo and in vitro models

por Barsby, Tom, Otonkoski, Timo
Publicado 2022

Concise Review: Human Pluripotent Stem Cells for the Modeling of Pancreatic β‐Cell Pathology

por Balboa, Diego, Saarimäki‐Vire, Jonna, Otonkoski, Timo
Publicado 2018

In vitro beta-cell killing models using immune cells and human pluripotent stem cell-derived islets: Challenges and opportunities

por Halliez, Clémentine, Ibrahim, Hazem, Otonkoski, Timo, Mallone, Roberto
Publicado 2023

Genome editing of human pancreatic beta cell models: problems, possibilities and outlook

por Balboa, Diego, Prasad, Rashmi B., Groop, Leif, Otonkoski, Timo
Publicado 2019

Long-Term Outcome and Treatment in Persistent and Transient Congenital Hyperinsulinism: A Finnish Population-Based Study

por Männistö, Jonna M E, Jääskeläinen, Jarmo, Otonkoski, Timo, Huopio, Hanna
Publicado 2021

EGFR Signaling Promotes β-Cell Proliferation and Survivin Expression during Pregnancy

por Hakonen, Elina, Ustinov, Jarkko, Palgi, Jaan, Miettinen, Päivi J., Otonkoski, Timo
Publicado 2014

Conditionally Stabilized dCas9 Activator for Controlling Gene Expression in Human Cell Reprogramming and Differentiation

por Balboa, Diego, Weltner, Jere, Eurola, Solja, Trokovic, Ras, Wartiovaara, Kirmo, Otonkoski, Timo
Publicado 2015

sept7b is required for the differentiation of pancreatic endocrine progenitors

por Dash, Surjya Narayan, Hakonen, Elina, Ustinov, Jarkko, Otonkoski, Timo, Andersson, Olov, Lehtonen, Sanna
Publicado 2016

Simultaneous high-efficiency base editing and reprogramming of patient fibroblasts

por Jalil, Sami, Keskinen, Timo, Maldonado, Rocío, Sokka, Joonas, Trokovic, Ras, Otonkoski, Timo, Wartiovaara, Kirmo
Publicado 2021

Intestinal Commitment and Maturation of Human Pluripotent Stem Cells Is Independent of Exogenous FGF4 and R-spondin1

por Tamminen, Kaisa, Balboa, Diego, Toivonen, Sanna, Pakarinen, Mikko P., Wiener, Zoltan, Alitalo, Kari, Otonkoski, Timo
Publicado 2015

Integrative genomics and transcriptomics analysis of human embryonic and induced pluripotent stem cells

por Laurila, Kirsti, Autio, Reija, Kong, Lingjia, Närvä, Elisa, Hussein, Samer, Otonkoski, Timo, Lahesmaa, Riitta, Lähdesmäki, Harri
Publicado 2014

A Strong Contractile Actin Fence and Large Adhesions Direct Human Pluripotent Colony Morphology and Adhesion

por Närvä, Elisa, Stubb, Aki, Guzmán, Camilo, Blomqvist, Matias, Balboa, Diego, Lerche, Martina, Saari, Markku, Otonkoski, Timo, Ivaska, Johanna
Publicado 2017

Characterization of neural crest-derived stem cells isolated from human bone marrow for improvement of transplanted islet function

por Brboric, Anja, Vasylovska, Svitlana, Saarimäki-Vire, Jonna, Espes, Daniel, Caballero-Corbalan, José, Larfors, Gunnar, Otonkoski, Timo, Lau, Joey
Publicado 2019

High-throughput karyotyping of human pluripotent stem cells

por Lund, Riikka J., Nikula, Tuomas, Rahkonen, Nelly, Närvä, Elisa, Baker, Duncan, Harrison, Neil, Andrews, Peter, Otonkoski, Timo, Lahesmaa, Riitta
Publicado 2012

mtDNA Mutagenesis Disrupts Pluripotent Stem Cell Function by Altering Redox Signaling

por Hämäläinen, Riikka H., Ahlqvist, Kati J., Ellonen, Pekka, Lepistö, Maija, Logan, Angela, Otonkoski, Timo, Murphy, Michael P., Suomalainen, Anu
Publicado 2015

Human pluripotent reprogramming with CRISPR activators

por Weltner, Jere, Balboa, Diego, Katayama, Shintaro, Bespalov, Maxim, Krjutškov, Kaarel, Jouhilahti, Eeva-Mari, Trokovic, Ras, Kere, Juha, Otonkoski, Timo
Publicado 2018

Differentiating functional human islet-like aggregates from pluripotent stem cells

por Barsby, Tom, Ibrahim, Hazem, Lithovius, Väinö, Montaser, Hossam, Balboa, Diego, Vähäkangas, Eliisa, Chandra, Vikash, Saarimäki-Vire, Jonna, Otonkoski, Timo
Publicado 2022

A Novel Feeder-Free Culture System for Human Pluripotent Stem Cell Culture and Induced Pluripotent Stem Cell Derivation

por Vuoristo, Sanna, Toivonen, Sanna, Weltner, Jere, Mikkola, Milla, Ustinov, Jarkko, Trokovic, Ras, Palgi, Jaan, Lund, Riikka, Tuuri, Timo, Otonkoski, Timo
Publicado 2013