Induction of Sphk1 activity in obese adipose tissue macrophages promotes survival

por Gabriel, Tanit L., Mirzaian, Mina, Hooibrink, Berend, Ottenhoff, Roelof, van Roomen, Cindy, Aerts, Johannes M. F. G., van Eijk, Marco
Publicado 2017

Identification of the ER-resident E3 ubiquitin ligase RNF145 as a novel LXR-regulated gene

por Cook, Emma C. L., Nelson, Jessica K., Sorrentino, Vincenzo, Koenis, Duco, Moeton, Martina, Scheij, Saskia, Ottenhoff, Roelof, Bleijlevens, Boris, Loregger, Anke, Zelcer, Noam
Publicado 2017

Investigations on therapeutic glucocerebrosidases through paired detection with fluorescent activity-based probes

por Kallemeijn, Wouter W., Scheij, Saskia, Hoogendoorn, Sascha, Witte, Martin D., Herrera Moro Chao, Daniela, van Roomen, Cindy P. A. A., Ottenhoff, Roelof, Overkleeft, Herman S., Boot, Rolf G., Aerts, Johannes M. F. G.
Publicado 2017

Gpnmb Is a Potential Marker for the Visceral Pathology in Niemann-Pick Type C Disease

por Marques, André R. A., Gabriel, Tanit L., Aten, Jan, van Roomen, Cindy P. A. A., Ottenhoff, Roelof, Claessen, Nike, Alfonso, Pilar, Irún, Pilar, Giraldo, Pilar, Aerts, Johannes M. F. G., van Eijk, Marco
Publicado 2016

Correction of Liver Steatosis by a Hydrophobic Iminosugar Modulating Glycosphingolipids Metabolism

por Lombardo, Elisa, van Roomen, Cindy P. A. A., van Puijvelde, Gijs H., Ottenhoff, Roelof, van Eijk, Marco, Aten, Jan, Kuiper, Johan, Overkleeft, Herman S., Groen, Albert K., Verhoeven, Arthur J., Aerts, Johannes M. F. G., Bietrix, Florence
Publicado 2012

GCase and LIMP2 Abnormalities in the Liver of Niemann Pick Type C Mice

por van der Lienden, Martijn J. C., Aten, Jan, Marques, André R. A., Waas, Ingeborg S. E., Larsen, Per W. B., Claessen, Nike, van der Wel, Nicole N., Ottenhoff, Roelof, van Eijk, Marco, Aerts, Johannes M. F. G.
Publicado 2021

Reducing Glycosphingolipid Content in Adipose Tissue of Obese Mice Restores Insulin Sensitivity, Adipogenesis and Reduces Inflammation

por van Eijk, Marco, Aten, Jan, Bijl, Nora, Ottenhoff, Roelof, van Roomen, Cindy P. A. A., Dubbelhuis, Peter F., Seeman, Ingar, Ghauharali-van der Vlugt, Karen, Overkleeft, Hermen S., Arbeeny, Cynthia, Groen, Albert K., Aerts, Johannes M. F. G.
Publicado 2009

Chemical Proteomic Analysis of Serine Hydrolase Activity in Niemann-Pick Type C Mouse Brain

por van Rooden, Eva J., van Esbroeck, Annelot C. M., Baggelaar, Marc P., Deng, Hui, Florea, Bogdan I., Marques, André R. A., Ottenhoff, Roelof, Boot, Rolf G., Overkleeft, Herman S., Aerts, Johannes M. F. G., van der Stelt, Mario
Publicado 2018

Inactivation of the E3 Ubiquitin Ligase IDOL Attenuates Diet-Induced Obesity and Metabolic Dysfunction in Mice

por van Loon, Nienke M., Ottenhoff, Roelof, Kooijman, Sander, Moeton, Martina, Scheij, Saskia, Roscam Abbing, Reinout L.P., Gijbels, Marion J.J., Levels, Johannes H.M., Sorrentino, Vincenzo, Berbée, Jimmy F.P., Rensen, Patrick C.N., Zelcer, Noam
Publicado 2018

Hepatic SREBP signaling requires SPRING to govern systemic lipid metabolism in mice and humans

por Hendrix, Sebastian, Kingma, Jenina, Ottenhoff, Roelof, Valiloo, Masoud, Svecla, Monika, Zijlstra, Lobke F., Sachdev, Vinay, Kovac, Kristina, Levels, Johannes H. M., Jongejan, Aldo, de Boer, Jan F., Kuipers, Folkert, Rimbert, Antoine, Norata, Giuseppe D., Loregger, Anke, Zelcer, Noam
Publicado 2023

A PPARγ-Bnip3 Axis Couples Adipose Mitochondrial Fusion-Fission Balance to Systemic Insulin Sensitivity

por Tol, Marc J., Ottenhoff, Roelof, van Eijk, Marco, Zelcer, Noam, Aten, Jan, Houten, Sander M., Geerts, Dirk, van Roomen, Cindy, Bierlaagh, Marlou C., Scheij, Saskia, Hoeksema, Marten A., Aerts, Johannes M., Bogan, Jonathan S., Dorn, Gerald W., Argmann, Carmen A., Verhoeven, Arthur J.
Publicado 2016

Elevation of glycoprotein nonmetastatic melanoma protein B in type 1 Gaucher disease patients and mouse models

por Kramer, Gertjan, Wegdam, Wouter, Donker‐Koopman, Wilma, Ottenhoff, Roelof, Gaspar, Paulo, Verhoek, Marri, Nelson, Jessica, Gabriel, Tanit, Kallemeijn, Wouter, Boot, Rolf G., Laman, Jon D., Vissers, Johannes P.C., Cox, Timothy, Pavlova, Elena, Moran, Mary Teresa, Aerts, Johannes M., van Eijk, Marco
Publicado 2016

Reducing GBA2 Activity Ameliorates Neuropathology in Niemann-Pick Type C Mice

por Marques, André R. A., Aten, Jan, Ottenhoff, Roelof, van Roomen, Cindy P. A. A., Herrera Moro, Daniela, Claessen, Nike, Vinueza Veloz, María Fernanda, Zhou, Kuikui, Lin, Zhanmin, Mirzaian, Mina, Boot, Rolf G., De Zeeuw, Chris I., Overkleeft, Herman S., Yildiz, Yildiz, Aerts, Johannes M. F. G.
Publicado 2015

Human glucocerebrosidase mediates formation of xylosyl-cholesterol by β-xylosidase and transxylosidase reactions

por Boer, Daphne E., Mirzaian, Mina, Ferraz, Maria J., Zwiers, Kimberley C., Baks, Merel V., Hazeu, Marc D., Ottenhoff, Roelof, Marques, André R.A., Meijer, Rianne, Roos, Jonathan C.P., Cox, Timothy M., Boot, Rolf G., Pannu, Navraj, Overkleeft, Herman S., Artola, Marta, Aerts, Johannes M.
Publicado 2021

Visualization of Active Glucocerebrosidase in Rodent Brain with High Spatial Resolution following In Situ Labeling with Fluorescent Activity Based Probes

por Herrera Moro Chao, Daniela, Kallemeijn, Wouter W., Marques, Andre R. A., Orre, Marie, Ottenhoff, Roelof, van Roomen, Cindy, Foppen, Ewout, Renner, Maria C., Moeton, Martina, van Eijk, Marco, Boot, Rolf G., Kamphuis, Willem, Hol, Elly M., Aten, Jan, Overkleeft, Hermen S., Kalsbeek, Andries, Aerts, Johannes M. F. G.
Publicado 2015

Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism

por Loregger, Anke, Raaben, Matthijs, Nieuwenhuis, Joppe, Tan, Josephine M. E., Jae, Lucas T., van den Hengel, Lisa G., Hendrix, Sebastian, van den Berg, Marlene, Scheij, Saskia, Song, Ji-Ying, Huijbers, Ivo J., Kroese, Lona J., Ottenhoff, Roelof, van Weeghel, Michel, van de Sluis, Bart, Brummelkamp, Thijn, Zelcer, Noam
Publicado 2020

Stabilization of Glucocerebrosidase by Active Site Occupancy

por Ben Bdira, Fredj, Kallemeijn, Wouter W., Oussoren, Saskia V., Scheij, Saskia, Bleijlevens, Boris, Florea, Bogdan I., van Roomen, Cindy P. A. A., Ottenhoff, Roelof, van Kooten, Marielle J. F. M., Walvoort, Marthe T. C., Witte, Martin D., Boot, Rolf G., Ubbink, Marcellus, Overkleeft, Herman S., Aerts, Johannes M. F. G.
Publicado 2017

Sterol-regulated transmembrane protein TMEM86a couples LXR signaling to regulation of lysoplasmalogens in macrophages

por van Wouw, Suzanne A.E., van den Berg, Marlene, El Ouraoui, Maroua, Meurs, Amber, Kingma, Jenina, Ottenhoff, Roelof, Loix, Melanie, Hoeksema, Marten A., Prange, Koen, Pasterkamp, Gerard, Hendriks, Jerome J.A., Bogie, Jeroen F.J., van Klinken, Jan B., Vaz, Frederic M., Jongejan, Aldo, de Winther, Menno P.J., Zelcer, Noam
Publicado 2022

Glucosylated cholesterol in mammalian cells and tissues: formation and degradation by multiple cellular β-glucosidases

por Marques, André R. A., Mirzaian, Mina, Akiyama, Hisako, Wisse, Patrick, Ferraz, Maria J., Gaspar, Paulo, Ghauharali-van der Vlugt, Karen, Meijer, Rianne, Giraldo, Pilar, Alfonso, Pilar, Irún, Pilar, Dahl, Maria, Karlsson, Stefan, Pavlova, Elena V., Cox, Timothy M., Scheij, Saskia, Verhoek, Marri, Ottenhoff, Roelof, van Roomen, Cindy P. A. A., Pannu, Navraj S., van Eijk, Marco, Dekker, Nick, Boot, Rolf G., Overkleeft, Herman S., Blommaart, Edward, Hirabayashi, Yoshio, Aerts, Johannes M.
Publicado 2016