Quercetin and luteolin are single-digit micromolar inhibitors of the SARS-CoV-2 RNA-dependent RNA polymerase

por Munafò, Federico, Donati, Elisa, Brindani, Nicoletta, Ottonello, Giuliana, Armirotti, Andrea, De Vivo, Marco
Publicado 2022

Design, synthesis, docking, and biochemical characterization of non-nucleoside SARS-CoV-2 RdRp inhibitors

por Brindani, Nicoletta, Munafò, Federico, Menichetti, Andrea, Donati, Elisa, Nigro, Michela, Ottonello, Giuliana, Armirotti, Andrea, De Vivo, Marco
Publicado 2023

Design, Synthesis, In Vitro and In Vivo Characterization of Selective NKCC1 Inhibitors for the Treatment of Core Symptoms in Down Syndrome

por Borgogno, Marco, Savardi, Annalisa, Manigrasso, Jacopo, Turci, Alessandra, Portioli, Corinne, Ottonello, Giuliana, Bertozzi, Sine Mandrup, Armirotti, Andrea, Contestabile, Andrea, Cancedda, Laura, De Vivo, Marco
Publicado 2021

Design, Synthesis, Dynamic Docking, Biochemical Characterization, and in Vivo Pharmacokinetics Studies of Novel Topoisomerase II Poisons with Promising Antiproliferative Activity

por Arencibia, Jose M., Brindani, Nicoletta, Franco-Ulloa, Sebastian, Nigro, Michela, Kuriappan, Jissy Akkarapattiakal, Ottonello, Giuliana, Bertozzi, Sine Mandrup, Summa, Maria, Girotto, Stefania, Bertorelli, Rosalia, Armirotti, Andrea, De Vivo, Marco
Publicado 2020

Design, Synthesis, and Biological Evaluation of a Series of Oxazolone Carboxamides as a Novel Class of Acid Ceramidase Inhibitors

por Caputo, Samantha, Di Martino, Simona, Cilibrasi, Vincenzo, Tardia, Piero, Mazzonna, Marco, Russo, Debora, Penna, Ilaria, Summa, Maria, Bertozzi, Sine Mandrup, Realini, Natalia, Margaroli, Natasha, Migliore, Marco, Ottonello, Giuliana, Liu, Min, Lansbury, Peter, Armirotti, Andrea, Bertorelli, Rosalia, Ray, Soumya S., Skerlj, Renato, Scarpelli, Rita
Publicado 2020

Lead Optimization of Benzoxazolone Carboxamides as Orally Bioavailable and CNS Penetrant Acid Ceramidase Inhibitors

por Di Martino, Simona, Tardia, Piero, Cilibrasi, Vincenzo, Caputo, Samantha, Mazzonna, Marco, Russo, Debora, Penna, Ilaria, Realini, Natalia, Margaroli, Natasha, Migliore, Marco, Pizzirani, Daniela, Ottonello, Giuliana, Bertozzi, Sine Mandrup, Armirotti, Andrea, Nguyen, Duc, Sun, Ying, Bongarzone, Ernesto R., Lansbury, Peter, Liu, Min, Skerlj, Renato, Scarpelli, Rita
Publicado 2020

Identification, Structure–Activity Relationship, and Biological Characterization of 2,3,4,5-Tetrahydro-1H-pyrido[4,3-b]indoles as a Novel Class of CFTR Potentiators

por Brindani, Nicoletta, Gianotti, Ambra, Giovani, Simone, Giacomina, Francesca, Di Fruscia, Paolo, Sorana, Federico, Bertozzi, Sine Mandrup, Ottonello, Giuliana, Goldoni, Luca, Penna, Ilaria, Russo, Debora, Summa, Maria, Bertorelli, Rosalia, Ferrera, Loretta, Pesce, Emanuela, Sondo, Elvira, Galietta, Luis J. V., Bandiera, Tiziano, Pedemonte, Nicoletta, Bertozzi, Fabio
Publicado 2020