A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model

por Zhang, Bin, Yao, Yuemang, Cornec, Anne-Sophie, Oukoloff, Killian, James, Michael J., Koivula, Pyry, Trojanowski, John Q., Smith, Amos B., Lee, Virginia M.-Y., Ballatore, Carlo, Brunden, Kurt R.
Publicado 2018

Multitargeted Imidazoles: Potential Therapeutic Leads for Alzheimer’s and Other Neurodegenerative Diseases

por Cornec, Anne-Sophie, Monti, Ludovica, Kovalevich, Jane, Makani, Vishruti, James, Michael J., Vijayendran, Krishna G., Oukoloff, Killian, Yao, Yuemang, Lee, Virginia M.-Y., Trojanowski, John Q., Smith, Amos B., Brunden, Kurt R., Ballatore, Carlo
Publicado 2017

Inhibition of the HEG1–KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells

por Lopez‐Ramirez, Miguel Alejandro, McCurdy, Sara, Li, Wenqing, Haynes, Mark K., Hale, Preston, Francisco, Karol, Oukoloff, Killian, Bautista, Matthew, Choi, Chelsea H.J., Sun, Hao, Gongol, Brendan, Shyy, John Y., Ballatore, Carlo, Sklar, Larry A., Gingras, Alexandre R.
Publicado 2021

Microtubule-Stabilizing 1,2,4-Triazolo[1,5-a]pyrimidines as Candidate Therapeutics for Neurodegenerative Disease: Matched Molecular Pair Analyses and Computational Studies Reveal N...

por Alle, Thibault, Varricchio, Carmine, Yao, Yuemang, Lucero, Bobby, Nzou, Goodwell, Demuro, Stefania, Muench, Megan, Vuong, Khoa D., Oukoloff, Killian, Cornec, Anne-Sophie, Francisco, Karol R., Caffrey, Conor R., Lee, Virginia M.-Y., Smith, Amos B., Brancale, Andrea, Brunden, Kurt R., Ballatore, Carlo
Publicado 2022