Structure and function of microbial α-l-fucosidases: a mini review

por Wu, Haiyang, Owen, C. David, Juge, Nathalie
Publicado 2023

Sialidases from gut bacteria: a mini-review

por Juge, Nathalie, Tailford, Louise, Owen, C David
Publicado 2016

Biochemical and structural basis of sialic acid utilization by gut microbes

por Bell, Andrew, Severi, Emmanuele, Owen, C David, Latousakis, Dimitrios, Juge, Nathalie
Publicado 2023

Streptococcus pneumoniae NanC: STRUCTURAL INSIGHTS INTO THE SPECIFICITY AND MECHANISM OF A SIALIDASE THAT PRODUCES A SIALIDASE INHIBITOR

por Owen, C. David, Lukacik, Petra, Potter, Jane A., Sleator, Olivia, Taylor, Garry L., Walsh, Martin A.
Publicado 2015

Discovery of intramolecular trans-sialidases in human gut microbiota suggests novel mechanisms of mucosal adaptation

por Tailford, Louise E., Owen, C. David, Walshaw, John, Crost, Emmanuelle H., Hardy-Goddard, Jemma, Le Gall, Gwenaelle, de Vos, Willem M., Taylor, Garry L., Juge, Nathalie
Publicado 2015

Investigation of the milling characteristics of different focused-ion-beam sources assessed by three-dimensional electron diffraction from crystal lamellae

por Parkhurst, James M., Crawshaw, Adam D., Siebert, C. Alistair, Dumoux, Maud, Owen, C. David, Nunes, Pedro, Waterman, David, Glen, Thomas, Stuart, David I., Naismith, James H., Evans, Gwyndaf
Publicado 2023

An in-solution snapshot of SARS-COV-2 main protease maturation process and inhibition

por Noske, Gabriela Dias, Song, Yun, Fernandes, Rafaela Sachetto, Chalk, Rod, Elmassoudi, Haitem, Koekemoer, Lizbé, Owen, C. David, El-Baba, Tarick J., Robinson, Carol V., Oliva, Glaucius, Godoy, Andre Schutzer
Publicado 2023

Penicillin Derivatives Inhibit the SARS-CoV-2 Main Protease by Reaction with Its Nucleophilic Cysteine

por Malla, Tika R., Brewitz, Lennart, Muntean, Dorian-Gabriel, Aslam, Hiba, Owen, C. David, Salah, Eidarus, Tumber, Anthony, Lukacik, Petra, Strain-Damerell, Claire, Mikolajek, Halina, Walsh, Martin A., Schofield, Christopher J.
Publicado 2022

Elucidation of a unique sialic acid metabolism pathway in mucus-foraging Ruminococcus gnavus unravels mechanisms of bacterial adaptation to the gut

por Bell, Andrew, Brunt, Jason, Crost, Emmanuelle, Vaux, Laura, Nepravishta, Ridvan, Owen, C. David, Latousakis, Dimitrios, Xiao, An, Li, Wanqing, Chen, Xi, Walsh, Martin A., Claesen, Jan, Angulo, Jesus, Thomas, Gavin H., Juge, Nathalie
Publicado 2019

xia2.multiplex: a multi-crystal data-analysis pipeline

por Gildea, Richard J., Beilsten-Edmands, James, Axford, Danny, Horrell, Sam, Aller, Pierre, Sandy, James, Sanchez-Weatherby, Juan, Owen, C. David, Lukacik, Petra, Strain-Damerell, Claire, Owen, Robin L., Walsh, Martin A., Winter, Graeme
Publicado 2022

The structure of nontypeable Haemophilus influenzae SapA in a closed conformation reveals a constricted ligand-binding cavity and a novel RNA binding motif

por Lukacik, Petra, Owen, C. David, Harris, Gemma, Bolla, Jani Reddy, Picaud, Sarah, Alibay, Irfan, Nettleship, Joanne E., Bird, Louise E., Owens, Raymond J., Biggin, Philip C., Filippakopoulos, Panagis, Robinson, Carol V., Walsh, Martin A.
Publicado 2021

Mass spectrometry reveals potential of β-lactams as SARS-CoV-2 M(pro) inhibitors

por Malla, Tika R., Tumber, Anthony, John, Tobias, Brewitz, Lennart, Strain-Damerell, Claire, Owen, C David, Lukacik, Petra, Chan, H. T. Henry, Maheswaran, Pratheesh, Salah, Eidarus, Duarte, Fernanda, Yang, Haitao, Rao, Zihe, Walsh, Martin A., Schofield, Christopher J.
Publicado 2021

Fucosidases from the human gut symbiont Ruminococcus gnavus

por Wu, Haiyang, Rebello, Osmond, Crost, Emmanuelle H., Owen, C. David, Walpole, Samuel, Bennati-Granier, Chloe, Ndeh, Didier, Monaco, Serena, Hicks, Thomas, Colvile, Anna, Urbanowicz, Paulina A., Walsh, Martin A., Angulo, Jesus, Spencer, Daniel I. R., Juge, Nathalie
Publicado 2020

An automatic pipeline for the design of irreversible derivatives identifies a potent SARS-CoV-2 M(pro) inhibitor

por Zaidman, Daniel, Gehrtz, Paul, Filep, Mihajlo, Fearon, Daren, Gabizon, Ronen, Douangamath, Alice, Prilusky, Jaime, Duberstein, Shirly, Cohen, Galit, Owen, C. David, Resnick, Efrat, Strain-Damerell, Claire, Lukacik, Petra, Barr, Haim, Walsh, Martin A., von Delft, Frank, London, Nir
Publicado 2021

In vitro selection of macrocyclic peptide inhibitors containing cyclic γ(2,4)-amino acids targeting the SARS-CoV-2 main protease

por Miura, Takashi, Malla, Tika R., Owen, C. David, Tumber, Anthony, Brewitz, Lennart, McDonough, Michael A., Salah, Eidarus, Terasaka, Naohiro, Katoh, Takayuki, Lukacik, Petra, Strain-Damerell, Claire, Mikolajek, Halina, Walsh, Martin A., Kawamura, Akane, Schofield, Christopher J., Suga, Hiroaki
Publicado 2023

Unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus

por Owen, C. David, Tailford, Louise E., Monaco, Serena, Šuligoj, Tanja, Vaux, Laura, Lallement, Romane, Khedri, Zahra, Yu, Hai, Lecointe, Karine, Walshaw, John, Tribolo, Sandra, Horrex, Marc, Bell, Andrew, Chen, Xi, Taylor, Gary L., Varki, Ajit, Angulo, Jesus, Juge, Nathalie
Publicado 2017

Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine

por Brewitz, Lennart, Dumjahn, Leo, Zhao, Yilin, Owen, C. David, Laidlaw, Stephen M., Malla, Tika R., Nguyen, Dung, Lukacik, Petra, Salah, Eidarus, Crawshaw, Adam D., Warren, Anna J., Trincao, Jose, Strain-Damerell, Claire, Carroll, Miles W., Walsh, Martin A., Schofield, Christopher J.
Publicado 2023

The human gut symbiont Ruminococcus gnavus shows specificity to blood group A antigen during mucin glycan foraging: Implication for niche colonisation in the gastrointestinal tract

por Wu, Haiyang, Crost, Emmanuelle H., Owen, C David, van Bakel, Wouter, Martínez Gascueña, Ana, Latousakis, Dimitrios, Hicks, Thomas, Walpole, Samuel, Urbanowicz, Paulina A., Ndeh, Didier, Monaco, Serena, Sánchez Salom, Laura, Griffiths, Ryan, Reynolds, Raven S., Colvile, Anna, Spencer, Daniel I. R., Walsh, Martin, Angulo, Jesus, Juge, Nathalie
Publicado 2021

Accelerating drug target inhibitor discovery with a deep generative foundation model

por Chenthamarakshan, Vijil, Hoffman, Samuel C., Owen, C. David, Lukacik, Petra, Strain-Damerell, Claire, Fearon, Daren, Malla, Tika R., Tumber, Anthony, Schofield, Christopher J., Duyvesteyn, Helen M.E., Dejnirattisai, Wanwisa, Carrique, Loic, Walter, Thomas S., Screaton, Gavin R., Matviiuk, Tetiana, Mojsilovic, Aleksandra, Crain, Jason, Walsh, Martin A., Stuart, David I., Das, Payel
Publicado 2023

Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19

por Redhead, Martin A., Owen, C. David, Brewitz, Lennart, Collette, Amelia H., Lukacik, Petra, Strain-Damerell, Claire, Robinson, Sean W., Collins, Patrick M., Schäfer, Philipp, Swindells, Mark, Radoux, Chris J., Hopkins, Iva Navratilova, Fearon, Daren, Douangamath, Alice, von Delft, Frank, Malla, Tika R., Vangeel, Laura, Vercruysse, Thomas, Thibaut, Jan, Leyssen, Pieter, Nguyen, Tu-Trinh, Hull, Mitchell, Tumber, Anthony, Hallett, David J., Schofield, Christopher J., Stuart, David I., Hopkins, Andrew L., Walsh, Martin A.
Publicado 2021