Plasmodium Niemann-Pick type C1-related protein is a druggable target required for parasite membrane homeostasis

por Istvan, Eva S, Das, Sudipta, Bhatnagar, Suyash, Beck, Josh R, Owen, Edward, Llinas, Manuel, Ganesan, Suresh M, Niles, Jacquin C, Winzeler, Elizabeth, Vaidya, Akhil B, Goldberg, Daniel E
Publicado 2019

Combining Stage Specificity and Metabolomic Profiling to Advance Antimalarial Drug Discovery

por Murithi, James M., Owen, Edward S., Istvan, Eva S., Lee, Marcus C.S., Ottilie, Sabine, Chibale, Kelly, Goldberg, Daniel E., Winzeler, Elizabeth A., Llinás, Manuel, Fidock, David A., Vanaerschot, Manu
Publicado 2020

PfMFR3: A Multidrug-Resistant Modulator in Plasmodium falciparum

por Rocamora, Frances, Gupta, Purva, Istvan, Eva S., Luth, Madeline R., Carpenter, Emma F., Kümpornsin, Krittikorn, Sasaki, Erika, Calla, Jaeson, Mittal, Nimisha, Carolino, Krypton, Owen, Edward, Llinás, Manuel, Ottilie, Sabine, Goldberg, Daniel E., Lee, Marcus C. S., Winzeler, Elizabeth A.
Publicado 2021

Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity

por Vanaerschot, Manu, Murithi, James M., Pasaje, Charisse Flerida A., Ghidelli-Disse, Sonja, Dwomoh, Louis, Bird, Megan, Spottiswoode, Natasha, Mittal, Nimisha, Arendse, Lauren B., Owen, Edward S., Wicht, Kathryn J., Siciliano, Giulia, Bösche, Markus, Yeo, Tomas, Kumar, T.R. Santha, Mok, Sachel, Carpenter, Emma F., Giddins, Marla J., Sanz, Olalla, Ottilie, Sabine, Alano, Pietro, Chibale, Kelly, Llinás, Manuel, Uhlemann, Anne-Catrin, Delves, Michael, Tobin, Andrew B., Doerig, Christian, Winzeler, Elizabeth A., Lee, Marcus C.S., Niles, Jacquin C., Fidock, David A.
Publicado 2020

Open-source discovery of chemical leads for next-generation chemoprotective antimalarials

por Antonova-Koch, Yevgeniya, Meister, Stephan, Abraham, Matthew, Luth, Madeline R., Ottilie, Sabine, Lukens, Amanda K., Sakata-Kato, Tomoyo, Vanaerschot, Manu, Owen, Edward, Jado, Juan Carlos, Maher, Steven P., Calla, Jaeson, Plouffe, David, Zhong, Yang, Chen, Kaisheng, Chaumeau, Victor, Conway, Amy J., McNamara, Case W., Ibanez, Maureen, Gagaring, Kerstin, Serrano, Fernando Neria, Eribez, Korina, Taggard, Cullin McLean, Cheung, Andrea L., Lincoln, Christie, Ambachew, Biniam, Rouillier, Melanie, Siegel, Dionicio, Nosten, François, Kyle, Dennis E., Gamo, Francisco-Javier, Zhou, Yingyao, Llinás, Manuel, Fidock, David A., Wirth, Dyann F., Burrows, Jeremy, Campo, Brice, Winzeler, Elizabeth A.
Publicado 2018

Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention

por Summers, Robert L., Pasaje, Charisse Flerida A., Pisco, Joao P., Striepen, Josefine, Luth, Madeline R., Kumpornsin, Krittikorn, Carpenter, Emma F., Munro, Justin T., Lin, De, Plater, Andrew, Punekar, Avinash S., Shepherd, Andrew M., Shepherd, Sharon M., Vanaerschot, Manu, Murithi, James M., Rubiano, Kelly, Akidil, Aslı, Ottilie, Sabine, Mittal, Nimisha, Dilmore, A. Hazel, Won, Madalyn, Mandt, Rebecca E.K., McGowen, Kerry, Owen, Edward, Walpole, Chris, Llinás, Manuel, Lee, Marcus C.S., Winzeler, Elizabeth A., Fidock, David A., Gilbert, Ian H., Wirth, Dyann F., Niles, Jacquin C., Baragaña, Beatriz, Lukens, Amanda K.
Publicado 2022

Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics

por Cowell, Annie N., Istvan, Eva S., Lukens, Amanda K., Gomez-Lorenzo, Maria G., Vanaerschot, Manu, Sakata-Kato, Tomoyo, Flannery, Erika L., Magistrado, Pamela, Owen, Edward, Abraham, Matthew, LaMonte, Gregory, Painter, Heather J., Williams, Roy M., Franco, Virginia, Linares, Maria, Arriaga, Ignacio, Bopp, Selina, Corey, Victoria C., Gnädig, Nina F., Coburn-Flynn, Olivia, Reimer, Christin, Gupta, Purva, Murithi, James M., Moura, Pedro A., Fuchs, Olivia, Sasaki, Erika, Kim, Sang W., Teng, Christine H., Wang, Lawrence T., Akidil, Aslı, Adjalley, Sophie, Willis, Paul A., Siege, Dionicio, Tanaseichuk, Olga, Zhong, Yang, Zhou, Yingyao, Llinás, Manuel, Ottilie, Sabine, Gamo, Francisco-Javier, Lee, Marcus C. S., Goldberg, Daniel E., Fidock, David A., Wirth, Dyann F., Winzeler, Elizabeth A.
Publicado 2018