Cofactor-Mediated Conformational Dynamics Promote Product Release From Escherichia coli Dihydrofolate Reductase via an Allosteric Pathway

por Oyen, David, Fenwick, R. Bryn, Stanfield, Robyn L., Dyson, H. Jane, Wright, Peter E.
Publicado 2015

An Engineered Human-Antibody Fragment with Fentanyl Pan-Specificity that Reverses Carfentanil-Induced Respiratory Depression

por Eubanks, Lisa M., Pholcharee, Tossapol, Oyen, David, Natori, Yoshihiro, Zhou, Bin, Wilson, Ian A., Janda, Kim D.
Publicado 2023

Cryo-EM structure of P. falciparum circumsporozoite protein with a vaccine-elicited antibody is stabilized by somatically mutated inter-Fab contacts

por Oyen, David, Torres, Jonathan L., Cottrell, Christopher A., Richter King, C., Wilson, Ian A., Ward, Andrew B.
Publicado 2018

Defining the Structural Basis for Allosteric Product Release from E. coli Dihydrofolate Reductase Using NMR Relaxation Dispersion

por Oyen, David, Fenwick, R. Bryn, Aoto, Phillip C., Stanfield, Robyn L., Wilson, Ian A., Dyson, H. Jane, Wright, Peter E.
Publicado 2017

A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine

por Wu, Nicholas C., Zost, Seth J., Thompson, Andrew J., Oyen, David, Nycholat, Corwin M., McBride, Ryan, Paulson, James C., Hensley, Scott E., Wilson, Ian A.
Publicado 2017

Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum

por Pholcharee, Tossapol, Oyen, David, Flores-Garcia, Yevel, Gonzalez-Paez, Gonzalo, Han, Zhen, Williams, Katherine L., Volkmuth, Wayne, Emerling, Daniel, Locke, Emily, Richter King, C., Zavala, Fidel, Wilson, Ian A.
Publicado 2021

Structural basis for antibody recognition of the NANP repeats in Plasmodium falciparum circumsporozoite protein

por Oyen, David, Torres, Jonathan L., Wille-Reece, Ulrike, Ockenhouse, Christian F., Emerling, Daniel, Glanville, Jacob, Volkmuth, Wayne, Flores-Garcia, Yevel, Zavala, Fidel, Ward, Andrew B., King, C. Richter, Wilson, Ian A.
Publicado 2017

Electron-Microscopy-Based Epitope Mapping Defines Specificities of Polyclonal Antibodies Elicited during HIV-1 BG505 Envelope Trimer Immunization

por Bianchi, Matteo, Turner, Hannah L., Nogal, Bartek, Cottrell, Christopher A., Oyen, David, Pauthner, Matthias, Bastidas, Raiza, Nedellec, Rebecca, McCoy, Laura E., Wilson, Ian A., Burton, Dennis R., Ward, Andrew B., Hangartner, Lars
Publicado 2018

Diverse Antibody Responses to Conserved Structural Motifs in Plasmodium falciparum Circumsporozoite Protein

por Pholcharee, Tossapol, Oyen, David, Torres, Jonathan L., Flores-Garcia, Yevel, Martin, Gregory M., González-Páez, Gonzalo E., Emerling, Daniel, Volkmuth, Wayne, Locke, Emily, King, C. Richter, Zavala, Fidel, Ward, Andrew B., Wilson, Ian A.
Publicado 2020

A high-affinity antibody against the CSP N-terminal domain lacks Plasmodium falciparum inhibitory activity

por Thai, Elaine, Costa, Giulia, Weyrich, Anna, Murugan, Rajagopal, Oyen, David, Flores-Garcia, Yevel, Prieto, Katherine, Bosch, Alexandre, Valleriani, Angelo, Wu, Nicholas C., Pholcharee, Tossapol, Scally, Stephen W., Wilson, Ian A., Wardemann, Hedda, Julien, Jean-Philippe, Levashina, Elena A.
Publicado 2020

Structural delineation and phase-dependent activation of the costimulatory CD27:CD70 complex

por Liu, Weifeng, Maben, Zachary, Wang, Carole, Lindquist, Kevin C., Li, Manqing, Rayannavar, Vinayak, Lopez Armenta, Ilsel, Nager, Andrew, Pascua, Edward, Dominik, Pawel K., Oyen, David, Wang, Hui, Roach, Rachel Carson, Allan, Corey M., Mosyak, Lidia, Chaparro-Riggers, Javier
Publicado 2021

Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein

por Oyen, David, Torres, Jonathan L., Aoto, Phillip C., Flores-Garcia, Yevel, Binter, Špela, Pholcharee, Tossapol, Carroll, Sean, Reponen, Sini, Wash, Rachael, Liang, Qi, Lemiale, Franck, Locke, Emily, Bradley, Allan, King, C. Richter, Emerling, Daniel, Kellam, Paul, Zavala, Fidel, Ward, Andrew B., Wilson, Ian A.
Publicado 2020

Affinity-matured homotypic interactions induce spectrum of PfCSP structures that influence protection from malaria infection

por Martin, Gregory M., Torres, Jonathan L., Pholcharee, Tossapol, Oyen, David, Flores-Garcia, Yevel, Gibson, Grace, Moskovitz, Re’em, Beutler, Nathan, Jung, Diana D., Copps, Jeffrey, Lee, Wen-Hsin, Gonzalez-Paez, Gonzalo, Emerling, Daniel, MacGill, Randall S., Locke, Emily, King, C. Richter, Zavala, Fidel, Wilson, Ian A., Ward, Andrew B.
Publicado 2023

A public antibody lineage that potently inhibits malaria infection by dual binding to the circumsporozoite protein

por Tan, Joshua, Sack, Brandon K, Oyen, David, Zenklusen, Isabelle, Piccoli, Luca, Barbieri, Sonia, Foglierini, Mathilde, Fregni, Chiara Silacci, Marcandalli, Jessica, Jongo, Said, Abdulla, Salim, Perez, Laurent, Corradin, Giampietro, Varani, Luca, Sallusto, Federica, Sim, B Kim Lee, Hoffman, Stephen L, Kappe, Stefan H I, Daubenberger, Claudia, Wilson, Ian A, Lanzavecchia, Antonio
Publicado 2018

A novel CSP C-terminal epitope targeted by an antibody with protective activity against Plasmodium falciparum

por Beutler, Nathan, Pholcharee, Tossapol, Oyen, David, Flores-Garcia, Yevel, MacGill, Randall S., Garcia, Elijah, Calla, Jaeson, Parren, Mara, Yang, Linlin, Volkmuth, Wayne, Locke, Emily, Regules, Jason A., Dutta, Sheetij, Emerling, Daniel, Early, Angela M., Neafsey, Daniel E., Winzeler, Elizabeth A., King, C. Richter, Zavala, Fidel, Burton, Dennis R., Wilson, Ian A., Rogers, Thomas F.
Publicado 2022

Functional human IgA targets a conserved site on malaria sporozoites

por Tan, Joshua, Cho, Hyeseon, Pholcharee, Tossapol, Pereira, Lais S., Doumbo, Safiatou, Doumtabe, Didier, Flynn, Barbara J., Schön, Arne, Kanatani, Sachie, Aylor, Samantha O., Oyen, David, Vistein, Rachel, Wang, Lawrence, Dillon, Marlon, Skinner, Jeff, Peterson, Mary, Li, Shanping, Idris, Azza H., Molina-Cruz, Alvaro, Zhao, Ming, Olano, Lisa Renee, Lee, Patricia J., Roth, Alison, Sinnis, Photini, Barillas-Mury, Carolina, Kayentao, Kassoum, Ongoiba, Aissata, Francica, Joseph R., Traore, Boubacar, Wilson, Ian A., Seder, Robert A., Crompton, Peter D.
Publicado 2021

Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates

por Cottrell, Christopher A., van Schooten, Jelle, Bowman, Charles A., Yuan, Meng, Oyen, David, Shin, Mia, Morpurgo, Robert, van der Woude, Patricia, van Breemen, Mariëlle, Torres, Jonathan L., Patel, Raj, Gross, Justin, Sewall, Leigh M., Copps, Jeffrey, Ozorowski, Gabriel, Nogal, Bartek, Sok, Devin, Rakasz, Eva G., Labranche, Celia, Vigdorovich, Vladimir, Christley, Scott, Carnathan, Diane G., Sather, D. Noah, Montefiori, David, Silvestri, Guido, Burton, Dennis R., Moore, John P., Wilson, Ian A., Sanders, Rogier W., Ward, Andrew B., van Gils, Marit J.
Publicado 2020