Complexity of Generating Mouse Models to Study the Upper Motor Neurons: Let Us Shift Focus from Mice to Neurons

por Genc, Baris, Gozutok, Oge, Ozdinler, P. Hande
Publicado 2019

Mutations and Protein Interaction Landscape Reveal Key Cellular Events Perturbed in Upper Motor Neurons with HSP and PLS

por Gozutok, Oge, Helmold, Benjamin Ryan, Ozdinler, P. Hande
Publicado 2021

The Timing and Extent of Motor Neuron Vulnerability in ALS Correlates with Accumulation of Misfolded SOD1 Protein in the Cortex and in the Spinal Cord

por Genc, Baris, Gozutok, Oge, Kocak, Nuran, Ozdinler, P. Hande
Publicado 2020

Mitochondrial dysregulation occurs early in ALS motor cortex with TDP-43 pathology and suggests maintaining NAD(+) balance as a therapeutic strategy

por Gautam, Mukesh, Gunay, Aksu, Chandel, Navdeep S., Ozdinler, P. Hande
Publicado 2022

A Chemoattractant Role for NT-3 in Proprioceptive Axon Guidance

por Genç, Barış, Özdinler, P. Hande, Mendoza, April E, Erzurumlu, Reha S
Publicado 2004

Mitoautophagy: A Unique Self-Destructive Path Mitochondria of Upper Motor Neurons With TDP-43 Pathology Take, Very Early in ALS

por Gautam, Mukesh, Xie, Edward F., Kocak, Nuran, Ozdinler, P. Hande
Publicado 2019

Retrograde labeling, transduction, and genetic targeting allow cellular analysis of corticospinal motor neurons: implications in health and disease

por Jara, Javier H., Genç, Barış, Klessner, Jodi L., Özdinler, P. Hande
Publicado 2014

Absence of alsin function leads to corticospinal motor neuron vulnerability via novel disease mechanisms

por Gautam, Mukesh, Jara, Javier H., Sekerkova, Gabriella, Yasvoina, Marina V., Martina, Marco, Özdinler, P. Hande
Publicado 2016

Protein-protein interactions reveal key canonical pathways, upstream regulators, interactome domains, and novel targets in ALS

por Dervishi, Ina, Gozutok, Oge, Murnan, Kevin, Gautam, Mukesh, Heller, Daniel, Bigio, Eileen, Ozdinler, P. Hande
Publicado 2018

MCP1-CCR2 and neuroinflammation in the ALS motor cortex with TDP-43 pathology

por Jara, Javier H., Gautam, Mukesh, Kocak, Nuran, Xie, Edward F., Mao, Qinwen, Bigio, Eileen H., Özdinler, P. Hande
Publicado 2019

Upper motor neurons are a target for gene therapy and UCHL1 is necessary and sufficient to improve cellular integrity of diseased upper motor neurons

por Genç, Barış, Jara, Javier H., Sanchez, Santana S., Lagrimas, Amiko K. B., Gozutok, Oge, Kocak, Nuran, Zhu, Yongling, Özdinler, P. Hande
Publicado 2022

Corticospinal Motor Neurons Are Susceptible to Increased ER Stress and Display Profound Degeneration in the Absence of UCHL1 Function

por Jara, Javier H., Genç, Barış, Cox, Gregory A., Bohn, Martha C., Roos, Raymond P., Macklis, Jeffrey D., Ulupınar, Emel, Özdinler, P. Hande
Publicado 2015

2-Year-Old and 3-Year-Old Italian ALS Patients with Novel ALS2 Mutations: Identification of Key Metabolites in Their Serum and Plasma

por Gautam, Mukesh, Carratore, Renata Del, Helmold, Benjamin, Tessa, Alessandra, Gozutok, Oge, Chandel, Navdeep, Idrisoglu, Halil, Bongioanni, Paolo, Battini, Roberta, Ozdinler, P.Hande
Publicado 2022

Improving mitochondria and ER stability helps eliminate upper motor neuron degeneration that occurs due to mSOD1 toxicity and TDP‐43 pathology

por Genç, Barış, Gautam, Mukesh, Gözütok, Öge, Dervishi, Ina, Sanchez, Santana, Goshu, Gashaw M., Koçak, Nuran, Xie, Edward, Silverman, Richard B., Özdinler, P. Hande
Publicado 2021

Visualization of Sensory Neurons and Their Projections in an Upper Motor Neuron Reporter Line

por Genç, Barış, Lagrimas, Amiko Krisa Bunag, Kuru, Pınar, Hess, Robert, Tu, Michael William, Menichella, Daniela Maria, Miller, Richard J., Paller, Amy S., Özdinler, P. Hande
Publicado 2015

The Electrophysiological Determinants of Corticospinal Motor Neuron Vulnerability in ALS

por Jara, Javier H., Sheets, Patrick L., Nigro, Maximiliano José, Perić, Mina, Brooks, Carolyn, Heller, Daniel B., Martina, Marco, Andjus, Pavle R., Ozdinler, P. Hande
Publicado 2020

Apical dendrite degeneration, a novel cellular pathology for Betz cells in ALS

por Genç, Barış, Jara, Javier H., Lagrimas, Amiko K. B., Pytel, Peter, Roos, Raymond P., Mesulam, M. Marsel, Geula, Changiz, Bigio, Eileen H., Özdinler, P. Hande
Publicado 2017

Evidence for an early innate immune response in the motor cortex of ALS

por Jara, Javier H., Genç, Barış, Stanford, Macdonell J., Pytel, Peter, Roos, Raymond P., Weintraub, Sandra, Mesulam, M. Marsel, Bigio, Eileen H., Miller, Richard J., Özdinler, P. Hande
Publicado 2017

Complementary feature selection from alternative splicing events and gene expression for phenotype prediction

por Labuzzetta, Charles J, Antonio, Margaret L, Watson, Patricia M, Wilson, Robert C, Laboissonniere, Lauren A, Trimarchi, Jeffrey M, Genc, Baris, Ozdinler, P Hande, Watson, Dennis K, Anderson, Paul E
Publicado 2016

Modeling mammalian spermatogonial differentiation and meiotic initiation in vitro

por Kirsanov, Oleksandr, Johnson, Taylor, Malachowski, Taylor, Niedenberger, Bryan A., Gilbert, Emma A., Bhowmick, Debajit, Ozdinler, P. Hande, Gray, Douglas A., Fisher-Wellman, Kelsey, Hermann, Brian P., Geyer, Christopher B.
Publicado 2022