Roles of PI3Kγ and PI3Kδ in mantle cell lymphoma proliferation and migration contributing to efficacy of the PI3Kγ/δ inhibitor duvelisib

por Till, Kathleen J., Abdullah, Mariah, Alnassfan, Tahera, Janet, Gallardo Zapata, Marks, Thomas, Coma, Silvia, Weaver, David T., Pachter, Jonathan A., Pettitt, Andrew R., Slupsky, Joseph R.
Publicado 2023

Inhibition of FAK kinase activity preferentially targets cancer stem cells

por Kolev, Vihren N., Tam, Winnie F., Wright, Quentin G., McDermott, Sean P., Vidal, Christian M., Shapiro, Irina M., Xu, Qunli, Wicha, Max S., Pachter, Jonathan A., Weaver, David T.
Publicado 2017

The activation of SRC family kinases and focal adhesion kinase with the loss of the amplified, mutated EGFR gene contributes to the resistance to afatinib, erlotinib and osimertini...

por Murakami, Yuichi, Sonoda, Kahori, Abe, Hideyuki, Watari, Kosuke, Kusakabe, Daiki, Azuma, Koichi, Kawahara, Akihiko, Akiba, Jun, Oneyama, Chitose, Pachter, Jonathan A., Sakai, Kazuko, Nishio, Kazuto, Kuwano, Michihiko, Ono, Mayumi
Publicado 2017

Targeting Focal Adhesion Kinase Renders Pancreatic Cancers Responsive to Checkpoint Immunotherapy

por Jiang, Hong, Hegde, Samarth, Knolhoff, Brett L., Zhu, Yu, Herndon, John M., Meyer, Melissa A., Nywening, Timothy M., Hawkins, William G., Shapiro, Irina M., Weaver, David T., Pachter, Jonathan A., Wang-Gillam, Andrea, DeNardo, David G.
Publicado 2016

Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity

por Serrels, Alan, Lund, Tom, Serrels, Bryan, Byron, Adam, McPherson, Rhoanne C., von Kriegsheim, Alexander, Gómez-Cuadrado, Laura, Canel, Marta, Muir, Morwenna, Ring, Jennifer E., Maniati, Eleni, Sims, Andrew H., Pachter, Jonathan A., Brunton, Valerie G., Gilbert, Nick, Anderton, Stephen M., Nibbs, Robert J.B., Frame, Margaret C.
Publicado 2015

The extracellular matrix and focal adhesion kinase signaling regulate cancer stem cell function in pancreatic ductal adenocarcinoma

por Begum, Asma, Ewachiw, Theodore, Jung, Clinton, Huang, Ally, Norberg, K. Jessica, Marchionni, Luigi, McMillan, Ross, Penchev, Vesselin, Rajeshkumar, N. V., Maitra, Anirban, Wood, Laura, Wang, Chenguang, Wolfgang, Christopher, DeJesus-Acosta, Ana, Laheru, Daniel, Shapiro, Irina M., Padval, Mahesh, Pachter, Jonathan A., Weaver, David T., Rasheed, Zeshaan A., Matsui, William
Publicado 2017

Natural Killer cell activation, reduced ACE2, TMPRSS2, cytokines G-CSF, M-CSF and SARS-CoV-2-S pseudovirus infectivity by MEK inhibitor treatment of human cells

por Zhou, Lanlan, Huntington, Kelsey, Zhang, Shengliang, Carlsen, Lindsey, So, Eui-Young, Parker, Cassandra, Sahin, Ilyas, Safran, Howard, Kamle, Suchitra, Lee, Chang-Min, Lee, Chun Geun, Elias, Jack A., Campbell, Kerry S., Naik, Mandar T., Atwood, Walter J., Youssef, Emile, Pachter, Jonathan A., Navaraj, Arunasalam, Seyhan, Attila A., Liang, Olin, El-Deiry, Wafik S.
Publicado 2020

Tumor FAK orchestrates immunosuppression in ovarian cancer via the CD155/TIGIT axis

por Ozmadenci, Duygu, Shankara Narayanan, Jayanth S., Andrew, Jacob, Ojalill, Marjaana, Barrie, Allison M., Jiang, Shulin, Iyer, Samhita, Chen, Xiao Lei, Rose, Michael, Estrada, Valeria, Molinolo, Alfredo, Bertotto, Thomas, Mikulski, Zbigniew, McHale, Michael C., White, Rebekah R., Connolly, Denise C., Pachter, Jonathan A., Kuchroo, Vijay K., Stupack, Dwayne G., Schlaepfer, David D.
Publicado 2022

High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma

por Arang, Nadia, Lubrano, Simone, Ceribelli, Michele, Rigiracciolo, Damiano C., Saddawi-Konefka, Robert, Faraji, Farhoud, Ramirez, Sydney I., Kim, Daehwan, Tosto, Frances A., Stevenson, Erica, Zhou, Yuan, Wang, Zhiyong, Bogomolovas, Julius, Molinolo, Alfredo A., Swaney, Danielle L., Krogan, Nevan J., Yang, Jing, Coma, Silvia, Pachter, Jonathan A., Aplin, Andrew E., Alessi, Dario R., Thomas, Craig J., Gutkind, J. Silvio
Publicado 2023

FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy

por Diaz Osterman, Carlos J, Ozmadenci, Duygu, Kleinschmidt, Elizabeth G, Taylor, Kristin N, Barrie, Allison M, Jiang, Shulin, Bean, Lisa M, Sulzmaier, Florian J, Jean, Christine, Tancioni, Isabelle, Anderson, Kristen, Uryu, Sean, Cordasco, Edward A, Li, Jian, Chen, Xiao Lei, Fu, Guo, Ojalill, Marjaana, Rappu, Pekka, Heino, Jyrki, Mark, Adam M, Xu, Guorong, Fisch, Kathleen M, Kolev, Vihren N, Weaver, David T, Pachter, Jonathan A, Győrffy, Balázs, McHale, Michael T, Connolly, Denise C, Molinolo, Alfredo, Stupack, Dwayne G, Schlaepfer, David D
Publicado 2019