Direct AKT activation in tumor-infiltrating lymphocytes markedly increases interferon-γ (IFN-γ) for the regression of tumors resistant to PD-1 checkpoint blockade

por Santinon, François, Ezzahra, Bennani Fatima, Bachais, Meriem, Sarabia Pacis, Alain, Rudd, Christopher E.
Publicado 2022

Characterizing 5-hydroxymethylcytosine in human prefrontal cortex at single base resolution

por Gross, Jeffrey A., Pacis, Alain, Chen, Gary G., Barreiro, Luis B., Ernst, Carl, Turecki, Gustavo
Publicado 2015

Single-Cell RNA-Seq Analysis of Cells from Degenerating and Non-Degenerating Intervertebral Discs from the Same Individual Reveals New Biomarkers for Intervertebral Disc Degenerati...

por Cherif, Hosni, Mannarino, Matthew, Pacis, Alain Sarabia, Ragoussis, Jiannis, Rabau, Oded, Ouellet, Jean A., Haglund, Lisbet
Publicado 2022

Gene activation precedes DNA demethylation in response to infection in human dendritic cells

por Pacis, Alain, Mailhot-Léonard, Florence, Tailleux, Ludovic, Randolph, Haley E., Yotova, Vania, Dumaine, Anne, Grenier, Jean-Christophe, Barreiro, Luis B.
Publicado 2019

A coordinated progression of progenitor cell states initiates urinary tract development

por Sanchez-Ferras, Oraly, Pacis, Alain, Sotiropoulou, Maria, Zhang, Yuhong, Wang, Yu Chang, Bourgey, Mathieu, Bourque, Guillaume, Ragoussis, Jiannis, Bouchard, Maxime
Publicado 2021

Genome graphs detect human polymorphisms in active epigenomic state during influenza infection

por Groza, Cristian, Chen, Xun, Pacis, Alain, Simon, Marie-Michelle, Pramatarova, Albena, Aracena, Katherine A., Pastinen, Tomi, Barreiro, Luis B., Bourque, Guillaume
Publicado 2023

EpiVar Browser: advanced exploration of epigenomics data under controlled access

por Lougheed, David R, Liu, Hanshi, Aracena, Katherine A, Grégoire, Romain, Pacis, Alain, Pastinen, Tomi, Barreiro, Luis B, Joly, Yann, Bujold, David, Bourque, Guillaume
Publicado 2023

Transposable elements are associated with the variable response to influenza infection

por Chen, Xun, Pacis, Alain, Aracena, Katherine A., Gona, Saideep, Kwan, Tony, Groza, Cristian, Lin, Yen Lung, Sindeaux, Renata, Yotova, Vania, Pramatarova, Albena, Simon, Marie-Michelle, Pastinen, Tomi, Barreiro, Luis B., Bourque, Guillaume
Publicado 2023

Molecular Signature of CAID Syndrome: Noncanonical Roles of SGO1 in Regulation of TGF-β Signaling and Epigenomics

por Piché, Jessica, Gosset, Natacha, Legault, Lisa-Marie, Pacis, Alain, Oneglia, Andrea, Caron, Maxime, Chetaille, Philippe, Barreiro, Luis, Liu, Donghai, Qi, Xioyan, Nattel, Stanley, Leclerc, Séverine, Breton-Larrivée, Mélanie, McGraw, Serge, Andelfinger, Gregor
Publicado 2018

Loss of hepatic Flcn protects against fibrosis and inflammation by activating autophagy pathways

por Paquette, Mathieu, Yan, Ming, Ramírez-Reyes, Josué M. J., El-Houjeiri, Leeanna, Biondini, Marco, Dufour, Catherine R., Jeong, Hyeonju, Pacis, Alain, Giguère, Vincent, Estall, Jennifer L., Siegel, Peter M., Audet-Walsh, Étienne, Pause, Arnim
Publicado 2021

Modeling High-Grade Serous Ovarian Carcinoma Using a Combination of In Vivo Fallopian Tube Electroporation and CRISPR-Cas9–Mediated Genome Editing

por Teng, Katie, Ford, Matthew J., Harwalkar, Keerthana, Li, YuQi, Pacis, Alain S., Farnell, David, Yamanaka, Nobuko, Wang, Yu-Chang, Badescu, Dunarel, Ton Nu, Tuyet Nhung, Ragoussis, Jiannis, Huntsman, David G., Arseneau, Jocelyne, Yamanaka, Yojiro
Publicado 2021

M. tuberculosis Reprograms Hematopoietic Stem Cells to Limit Myelopoiesis and Impair Trained Immunity

por Khan, Nargis, Downey, Jeffrey, Sanz, Joaquin, Kaufmann, Eva, Blankenhaus, Birte, Pacis, Alain, Pernet, Erwan, Ahmed, Eisha, Cardoso, Silvia, Nijnik, Anastasia, Mazer, Bruce, Sassetti, Christopher, Behr, Marcel A., Soares, Miguel P., Barreiro, Luis B., Divangahi, Maziar
Publicado 2020

Non-CG methylation and multiple histone profiles associate child abuse with immune and small GTPase dysregulation

por Lutz, Pierre-Eric, Chay, Marc-Aurèle, Pacis, Alain, Chen, Gary G., Aouabed, Zahia, Maffioletti, Elisabetta, Théroux, Jean-François, Grenier, Jean-Christophe, Yang, Jennie, Aguirre, Maria, Ernst, Carl, Redensek, Adriana, van Kempen, Léon C., Yalcin, Ipek, Kwan, Tony, Mechawar, Naguib, Pastinen, Tomi, Turecki, Gustavo
Publicado 2021

Coordinated activation of c-Src and FOXM1 drives tumor cell proliferation and breast cancer progression

por Nandi, Ipshita, Smith, Harvey W., Sanguin-Gendreau, Virginie, Ji, Linjia, Pacis, Alain, Papavasiliou, Vasilios, Zuo, Dongmei, Nam, Stella, Attalla, Sherif S., Kim, Sung Hoon, Lusson, Sierra, Kuasne, Hellen, Fortier, Anne-Marie, Savage, Paul, Martinez Ramirez, Constanza, Park, Morag, Katzenellenbogen, John A., Katzenellenbogen, Benita S., Muller, William J.
Publicado 2023

Chemokine expression predicts T cell-inflammation and improved survival with checkpoint inhibition across solid cancers

por Romero, Joan Miguel, Titmuss, Emma, Wang, Yifan, Vafiadis, James, Pacis, Alain, Jang, Gun Ho, Zhang, Amy, Golesworthy, Bryn, Lenko, Tatiana, Williamson, Laura M., Grünwald, Barbara, O’Kane, Grainne M., Jones, Steven J. M., Marra, Marco. A., Wilson, Julie M., Gallinger, Steven, Laskin, Janessa, Zogopoulos, George
Publicado 2023

Bacterial infection remodels the DNA methylation landscape of human dendritic cells

por Pacis, Alain, Tailleux, Ludovic, Morin, Alexander M., Lambourne, John, MacIsaac, Julia L., Yotova, Vania, Dumaine, Anne, Danckaert, Anne, Luca, Francesca, Grenier, Jean-Christophe, Hansen, Kasper D., Gicquel, Brigitte, Yu, Miao, Pai, Athma, He, Chuan, Tung, Jenny, Pastinen, Tomi, Kobor, Michael S., Pique-Regi, Roger, Gilad, Yoav, Barreiro, Luis B.
Publicado 2015

Single-cell RNA sequencing reveals time- and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links ApoE to chronic pain

por Tansley, Shannon, Uttam, Sonali, Ureña Guzmán, Alba, Yaqubi, Moein, Pacis, Alain, Parisien, Marc, Deamond, Haley, Wong, Calvin, Rabau, Oded, Brown, Nicole, Haglund, Lisbet, Ouellet, Jean, Santaguida, Carlo, Ribeiro-da-Silva, Alfredo, Tahmasebi, Soroush, Prager-Khoutorsky, Masha, Ragoussis, Jiannis, Zhang, Ji, Salter, Michael W., Diatchenko, Luda, Healy, Luke M., Mogil, Jeffrey S., Khoutorsky, Arkady
Publicado 2022

Chemogenomic profiling of breast cancer patient-derived xenografts reveals targetable vulnerabilities for difficult-to-treat tumors

por Savage, Paul, Pacis, Alain, Kuasne, Hellen, Liu, Leah, Lai, Daniel, Wan, Adrian, Dankner, Matthew, Martinez, Constanza, Muñoz-Ramos, Valentina, Pilon, Virginie, Monast, Anie, Zhao, Hong, Souleimanova, Margarita, Annis, Matthew G., Aguilar-Mahecha, Adriana, Lafleur, Josiane, Bertos, Nicholas R., Asselah, Jamil, Bouganim, Nathaniel, Petrecca, Kevin, Siegel, Peter M., Omeroglu, Atilla, Shah, Sohrab P., Aparicio, Samuel, Basik, Mark, Meterissian, Sarkis, Park, Morag
Publicado 2020

Intra-Tumoral CD8+ T-Cell Infiltration and PD-L1 Positivity in Homologous Recombination Deficient Pancreatic Ductal Adenocarcinoma

por Golesworthy, Bryn, Wang, Yifan, Tanti, Amanda, Pacis, Alain, Romero, Joan Miguel, Cuggia, Adeline, Domecq, Celine, Bourdel, Guillaume, Denroche, Robert E., Jang, Gun Ho, Grant, Robert C., Borgida, Ayelet, Grünwald, Barbara T., Dodd, Anna, Wilson, Julie M., Bourque, Guillaume, O’Kane, Grainne M., Fischer, Sandra E., Kron, Chelsea Maedler, Fiset, Pierre-Olivier, Omeroglu, Atilla, Foulkes, William D., Gallinger, Steven, Guiot, Marie-Christine, Gao, Zu-Hua, Zogopoulos, George
Publicado 2022

ADRA1A–Gα(q) signalling potentiates adipocyte thermogenesis through CKB and TNAP

por Rahbani, Janane F., Scholtes, Charlotte, Lagarde, Damien M., Hussain, Mohammed F., Roesler, Anna, Dykstra, Christien B., Bunk, Jakub, Samborska, Bozena, O’Brien, Shannon L., Tripp, Emma, Pacis, Alain, Angueira, Anthony R., Johansen, Olivia S., Cinkornpumin, Jessica, Hossain, Ishtiaque, Lynes, Matthew D., Zhang, Yang, White, Andrew P., Pastor, William A., Chondronikola, Maria, Sidossis, Labros, Klein, Samuel, Kralli, Anastasia, Cypess, Aaron M., Pedersen, Steen B., Jessen, Niels, Tseng, Yu-Hua, Gerhart-Hines, Zachary, Seale, Patrick, Calebiro, Davide, Giguère, Vincent, Kazak, Lawrence
Publicado 2022