Fragment-Based Approach to Targeting Inosine-5′-monophosphate Dehydrogenase (IMPDH) from Mycobacterium tuberculosis

por Trapero, Ana, Pacitto, Angela, Singh, Vinayak, Sabbah, Mohamad, Coyne, Anthony G., Mizrahi, Valerie, Blundell, Tom L., Ascher, David B., Abell, Chris
Publicado 2018

Lst4, the yeast Fnip1/2 orthologue, is a DENN-family protein

por Pacitto, Angela, Ascher, David B., Wong, Louise H., Blaszczyk, Beata K., Nookala, Ravi K., Zhang, Nianshu, Dokudovskaya, Svetlana, Levine, Tim P., Blundell, Tom L.
Publicado 2015

Synthesis and Structure–Activity relationship of 1-(5-isoquinolinesulfonyl)piperazine analogues as inhibitors of Mycobacterium tuberculosis IMPDH

por Singh, Vinayak, Pacitto, Angela, Donini, Stefano, Ferraris, Davide M., Boros, Sándor, Illyés, Eszter, Szokol, Bálint, Rizzi, Menico, Blundell, Tom L., Ascher, David B., Pato, Janos, Mizrahi, Valerie
Publicado 2019

Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer

por Nookala, Ravi K., Langemeyer, Lars, Pacitto, Angela, Ochoa-Montaño, Bernardo, Donaldson, Jane C., Blaszczyk, Beata K., Chirgadze, Dimitri Y., Barr, Francis A., Bazan, J. Fernando, Blundell, Tom L.
Publicado 2012

The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis

por Singh, Vinayak, Donini, Stefano, Pacitto, Angela, Sala, Claudia, Hartkoorn, Ruben C., Dhar, Neeraj, Keri, Gyorgy, Ascher, David B., Mondésert, Guillaume, Vocat, Anthony, Lupien, Andréanne, Sommer, Raphael, Vermet, Hélène, Lagrange, Sophie, Buechler, Joe, Warner, Digby F., McKinney, John D., Pato, Janos, Cole, Stewart T., Blundell, Tom L., Rizzi, Menico, Mizrahi, Valerie
Publicado 2016