Exploration of Targeted Anti-tumor Therapy: a contribution to the development of targeted therapies

por Normanno, Nicola, Packham, Graham
Publicado 2020

Targeted inhibition of mRNA translation initiation factors as a novel therapeutic strategy for mature B-cell neoplasms

por Taylor, Joe, Yeomans, Alison M, Packham, Graham
Publicado 2020

Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer

por Whitton, Bradleigh, Okamoto, Haruko, Packham, Graham, Crabb, Simon J.
Publicado 2018

Development of PROTACs to address clinical limitations associated with BTK-targeted kinase inhibitors

por Arthur, Rachael, Valle-Argos, Beatriz, Steele, Andrew J., Packham, Graham
Publicado 2020

The NF-κB p50:p50:HDAC-1 repressor complex orchestrates transcriptional inhibition of multiple pro-inflammatory genes

por Elsharkawy, Ahmed M., Oakley, Fiona, Lin, Feng, Packham, Graham, Mann, Derek A., Mann, Jelena
Publicado 2010

Epigenetic modulators as therapeutic targets in prostate cancer

por Graça, Inês, Pereira-Silva, Eva, Henrique, Rui, Packham, Graham, Crabb, Simon J., Jerónimo, Carmen
Publicado 2016

Metabolic targets of watercress and PEITC in MCF-7 and MCF-10A cells explain differential sensitisation responses to ionising radiation

por Giallourou, Natasa S., Rowland, Ian R., Rothwell, Steve D., Packham, Graham, Commane, Daniel M., Swann, Jonathan R.
Publicado 2018

High throughput imaging cytometer with acoustic focussing

por Zmijan, Robert, Jonnalagadda, Umesh S., Carugo, Dario, Kochi, Yu, Lemm, Elizabeth, Packham, Graham, Hill, Martyn, Glynne-Jones, Peter
Publicado 2015

Synthesis and Biological Evaluation of JAHAs: Ferrocene-Based Histone Deacetylase Inhibitors

por Spencer, John, Amin, Jahangir, Wang, Minghua, Packham, Graham, Alwi, Sharifah S. Syed, Tizzard, Graham J., Coles, Simon J., Paranal, Ronald M., Bradner, James E., Heightman, Tom D.
Publicado 2011

Targeted inhibition of eIF4A suppresses B-cell receptor-induced translation and expression of MYC and MCL1 in chronic lymphocytic leukemia cells

por Wilmore, Sarah, Rogers-Broadway, Karly-Rai, Taylor, Joe, Lemm, Elizabeth, Fell, Rachel, Stevenson, Freda K., Forconi, Francesco, Steele, Andrew J., Coldwell, Mark, Packham, Graham, Yeomans, Alison
Publicado 2021

Stratifying risk of recurrence in stage II colorectal cancer using deregulated stromal and epithelial microRNAs

por Bullock, Marc D., Pickard, Karen, Mitter, Richard, Sayan, A. Emre, Primrose, John N., Ivan, Cristina, Calin, George A., Thomas, Gareth J., Packham, Graham K., Mirnezami, Alex H.
Publicado 2015

A combination of trastuzumab and BAG-1 inhibition synergistically targets HER2 positive breast cancer cells

por Papadakis, Emmanouil, Robson, Natalia, Yeomans, Alison, Bailey, Sarah, Laversin, Stephanie, Beers, Stephen, Sayan, A. Emre, Ashton-Key, Margaret, Schwaiger, Stefan, Stuppner, Hermann, Troppmair, Jakob, Packham, Graham, Cutress, Ramsey
Publicado 2016

Annexin A3 is a mammary marker and a potential neoplastic breast cell therapeutic target

por Zeidan, Bashar, Jackson, Thomas R., Larkin, Samantha E.T., Cutress, Ramsey I., Coulton, Gary R., Ashton-Key, Margaret, Murray, Nick, Packham, Graham, Gorgoulis, Vassilis, Garbis, Spiros D., Townsend, Paul A.
Publicado 2015

LSD1 inhibition attenuates androgen receptor V7 splice variant activation in castration resistant prostate cancer models

por Regufe da Mota, Sergio, Bailey, Sarah, Strivens, Rosemary A., Hayden, Annette L., Douglas, Leon R., Duriez, Patrick J., Borrello, M. Teresa, Benelkebir, Hanae, Ganesan, A., Packham, Graham, Crabb, Simon J.
Publicado 2018

A Cyclic Peptide Inhibitor of HIF-1 Heterodimerization That Inhibits Hypoxia Signaling in Cancer Cells

por Miranda, Elena, Nordgren, Ida K., Male, Abigail L., Lawrence, Charlotte E., Hoakwie, Franciane, Cuda, Francesco, Court, William, Fox, Keith R., Townsend, Paul A., Packham, Graham K., Eccles, Suzanne A., Tavassoli, Ali
Publicado 2013

DC-SIGN binding to mannosylated B-cell receptors in follicular lymphoma down-modulates receptor signaling capacity

por Valle-Argos, Beatriz, Chiodin, Giorgia, Bryant, Dean J., Taylor, Joe, Lemm, Elizabeth, Duriez, Patrick J., Rock, Philip J., Strefford, Jonathan C., Forconi, Francesco, Burack, Richard W., Packham, Graham, Stevenson, Freda K.
Publicado 2021

B-cell receptor dependent phagocytosis and presentation of particulate antigen by chronic lymphocytic leukemia cells

por Minton, Annabel R., Smith, Lindsay D., Bryant, Dean J., Strefford, Jonathan C., Forconi, Francesco, Stevenson, Freda K., Tumbarello, David A., James, Edd, Løset, Geir Åge, Munthe, Ludvig A., Steele, Andrew J., Packham, Graham
Publicado 2022

Network analysis reveals a major role for 14q32 cluster miRNAs in determining transcriptional differences between IGHV-mutated and unmutated CLL

por Bryant, Dean, Smith, Lindsay, Rogers-Broadway, Karly Rai, Karydis, Laura, Woo, Jeongmin, Blunt, Matthew D., Forconi, Francesco, Stevenson, Freda K., Goodnow, Christopher, Russell, Amanda, Humburg, Peter, Packham, Graham, Steele, Andrew J., Strefford, Jonathan C.
Publicado 2023

B-cell receptor signaling induces proteasomal degradation of PDCD4 via MEK1/2 and mTORC1 in malignant B cells

por Taylor, Joe, Wilmore, Sarah, Marriot, Sophie, Rogers-Broadway, Karly-Rai, Fell, Rachel, Minton, Annabel R., Branch, Tom, Ashton-Key, Meg, Coldwell, Mark, Stevenson, Freda K., Forconi, Francesco, Steele, Andrew J., Packham, Graham, Yeomans, Alison
Publicado 2022

PEITC-mediated inhibition of mRNA translation is associated with both inhibition of mTORC1 and increased eIF2α phosphorylation in established cell lines and primary human leukemia...

por Yeomans, Alison, Lemm, Elizabeth, Wilmore, Sarah, Cavell, Breeze E., Valle-Argos, Beatriz, Krysov, Sergey, Hidalgo, Marina Sanchez, Leonard, Elodie, Willis, Anne E., Forconi, Francesco, Stevenson, Freda K., Steele, Andrew J., Coldwell, Mark J., Packham, Graham
Publicado 2016