Identification of 6-(piperazin-1-yl)-1,3,5-triazine as a chemical scaffold with broad anti-schistosomal activities

por Padalino, Gilda, Chalmers, Iain W., Brancale, Andrea, Hoffmann, Karl F.
Publicado 2020

Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni

por Padalino, Gilda, Ferla, Salvatore, Brancale, Andrea, Chalmers, Iain W., Hoffmann, Karl F.
Publicado 2018

Erratum to ‘Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni’ [IJP Drugs...

por Padalino, Gilda, Ferla, Salvatore, Brancale, Andrea, Chalmers, Iain W., Hoffmann, Karl F.
Publicado 2019

Identification of anti-schistosomal, anthelmintic and anti-parasitic compounds curated and text-mined from the scientific literature

por Coghlan, Avril, Padalino, Gilda, O'Boyle, Noel M., Hoffmann, Karl F., Berriman, Matthew
Publicado 2022

(Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach

por Cosseau, Céline, Wolkenhauer, Olaf, Padalino, Gilda, Geyer, Kathrin K., Hoffmann, Karl F., Grunau, Christoph
Publicado 2017

Using ChEMBL to Complement Schistosome Drug Discovery

por Padalino, Gilda, Coghlan, Avril, Pagliuca, Giampaolo, Forde-Thomas, Josephine E., Berriman, Matthew, Hoffmann, Karl F.
Publicado 2023

Histone methylation changes are required for life cycle progression in the human parasite Schistosoma mansoni

por Roquis, David, Taudt, Aaron, Geyer, Kathrin K., Padalino, Gilda, Hoffmann, Karl F., Holroyd, Nancy, Berriman, Matt, Aliaga, Benoît, Chaparro, Cristian, Grunau, Christoph, Augusto, Ronaldo de Carvalho
Publicado 2018

The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets

por Whatley, Kezia C. L., Padalino, Gilda, Whiteland, Helen, Geyer, Kathrin K., Hulme, Benjamin J., Chalmers, Iain W., Forde-Thomas, Josephine, Ferla, Salvatore, Brancale, Andrea, Hoffmann, Karl F.
Publicado 2019

Schistosoma mansoni Larval Extracellular Vesicle protein 1 (SmLEV1) is an immunogenic antigen found in EVs released from pre-acetabular glands of invading cercariae

por Gasan, Thomas A., Kuipers, Marije E., Roberts, Grisial H., Padalino, Gilda, Forde-Thomas, Josephine E., Wilson, Shona, Wawrzyniak, Jakub, Tukahebwa, Edridah M., Hoffmann, Karl F., Chalmers, Iain W.
Publicado 2021

Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes

por Padalino, Gilda, Celatka, Cassandra A., Rienhoff Jr., Hugh Y., Kalin, Jay H., Cole, Philip A., Lassalle, Damien, Forde-Thomas, Josephine, Chalmers, Iain W., Brancale, Andrea, Grunau, Christoph, Hoffmann, Karl F.
Publicado 2023

Schistosoma mansoni α-N-acetylgalactosaminidase (SmNAGAL) regulates coordinated parasite movement and egg production

por Hulme, Benjamin J., Geyer, Kathrin K., Forde-Thomas, Josephine E., Padalino, Gilda, Phillips, Dylan W., Ittiprasert, Wannaporn, Karinshak, Shannon E., Mann, Victoria H., Chalmers, Iain W., Brindley, Paul J., Hokke, Cornelis H., Hoffmann, Karl F.
Publicado 2022

Structural Investigations on Novel Non-Nucleoside Inhibitors of Human Norovirus Polymerase

por Giancotti, Gilda, Nannetti, Giulio, Padalino, Gilda, Landini, Martina, Santos-Ferreira, Nanci, Van Dycke, Jana, Naccarato, Valentina, Patel, Usheer, Silvestri, Romano, Neyts, Johan, Gozalbo-Rovira, Roberto, Rodríguez-Díaz, Jésus, Rocha-Pereira, Joana, Brancale, Andrea, Ferla, Salvatore, Bassetto, Marcella
Publicado 2022

Modified Hederagenin Derivatives Demonstrate Ex Vivo Anthelmintic Activity against Fasciola hepatica

por Chakroborty, Anand, Pritchard, Deiniol R., Bouillon, Marc E., Cervi, Anna, Kraehenbuehl, Rolf, Wild, Charlotte, Fenn, Caroline, Holdsworth, Peter, Capner, Colin, Padalino, Gilda, Forde-Thomas, Josephine E., Payne, Joseph, Smith, Brendan G., Fisher, Maggie, Lahmann, Martina, Baird, Mark S., Hoffmann, Karl F.
Publicado 2023

Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation

por Padalino, Gilda, El-Sakkary, Nelly, Liu, Lawrence J., Liu, Chenxi, Harte, Danielle S.G., Barnes, Rachel E., Sayers, Edward, Forde-Thomas, Josephine, Whiteland, Helen, Bassetto, Marcella, Ferla, Salvatore, Johnson, George, Jones, Arwyn T., Caffrey, Conor R., Chalmers, Iain, Brancale, Andrea, Hoffmann, Karl F.
Publicado 2021

Perspective on Schistosomiasis Drug Discovery: Highlights from a Schistosomiasis Drug Discovery Workshop at Wellcome Collection, London, September 2022

por Caldwell, Nicola, Afshar, Rana, Baragaña, Beatriz, Bustinduy, Amaya L., Caffrey, Conor R., Collins, James J., Fusco, Daniela, Garba, Amadou, Gardner, Mark, Gomes, Mireille, Hoffmann, Karl F., Hsieh, Michael, Lo, Nathan C., McNamara, Case W., Nono, Justin Komguep, Padalino, Gilda, Read, Kevin D., Roestenberg, Meta, Spangenberg, Thomas, Specht, Sabine, Gilbert, Ian H.
Publicado 2023