G9a/GLP-dependent H3K9me2 patterning alters chromatin structure at CpG islands in hematopoietic progenitors

por Schones, Dustin E, Chen, Xiaoji, Trac, Candi, Setten, Ryan, Paddison, Patrick J
Publicado 2014

Exit from Pluripotency Is Gated by Intracellular Redistribution of the bHLH Transcription Factor Tfe3

por Betschinger, Joerg, Nichols, Jennifer, Dietmann, Sabine, Corrin, Philip D., Paddison, Patrick J., Smith, Austin
Publicado 2013

Functional dissection of human mitotic genes using CRISPR–Cas9 tiling screens

por Herman, Jacob A., Arora, Sonali, Carter, Lucas, Zhu, Jun, Biggins, Sue, Paddison, Patrick J.
Publicado 2022

A simple and highly efficient method for multi‐allelic CRISPR‐Cas9 editing in primary cell cultures

por Hoellerbauer, Pia, Kufeld, Megan, Arora, Sonali, Wu, Hua‐Jun, Feldman, Heather M., Paddison, Patrick J.
Publicado 2020

Gene knock-outs in human CD34+ hematopoietic stem and progenitor cells and in the human immune system of mice

por Kuppers, Daniel A., Linton, Jonathan, Ortiz Espinosa, Sergio, McKenna, Kelly M., Rongvaux, Anthony, Paddison, Patrick J.
Publicado 2023

A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency

por Hsieh, Emily, Janssens, Derek H., Paddison, Patrick J., Browne, Edward P., Henikoff, Steve, OhAinle, Molly, Emerman, Michael
Publicado 2023

Ion channel expression patterns in glioblastoma stem cells with functional and therapeutic implications for malignancy

por Pollak, Julia, Rai, Karan G., Funk, Cory C., Arora, Sonali, Lee, Eunjee, Zhu, Jun, Price, Nathan D., Paddison, Patrick J., Ramirez, Jan-Marino, Rostomily, Robert C.
Publicado 2017

Both YAP1-MAML2 and constitutively active YAP1 drive the formation of tumors that resemble NF2 mutant meningiomas in mice

por Szulzewsky, Frank, Arora, Sonali, Arakaki, Aleena K.S., Sievers, Philipp, Almiron Bonnin, Damian A., Paddison, Patrick J., Sahm, Felix, Cimino, Patrick J., Gujral, Taranjit S., Holland, Eric C.
Publicado 2022

ZNF131 suppresses centrosome fragmentation in glioblastoma stem-like cells through regulation of HAUS5

por Ding, Yu, Herman, Jacob A., Toledo, Chad M., Lang, Jackie M., Corrin, Philip, Girard, Emily J., Basom, Ryan, Delrow, Jeffrey J., Olson, James M., Paddison, Patrick J.
Publicado 2017

Global and context-specific transcriptional consequences of oncogenic Fbw7 mutations

por Thirimanne, H Nayanga, Wu, Feinan, Janssens, Derek H, Swanger, Jherek, Diab, Ahmed, Feldman, Heather M, Amezquita, Robert A, Gottardo, Raphael, Paddison, Patrick J, Henikoff, Steven, Clurman, Bruce E
Publicado 2022

Hyper-active RAS/MAPK introduces cancer-specific mitotic vulnerabilities

por Herman, Jacob A., Romain, Romario R., Hoellerbauer, Pia, Shirnekhi, Hazheen K., King, David C., DeLuca, Keith F., Osborne Nishimura, Erin, Paddison, Patrick J., DeLuca, Jennifer G.
Publicado 2022

Histone deposition pathways determine the chromatin landscapes of H3.1 and H3.3 K27M oncohistones

por Sarthy, Jay F, Meers, Michael P, Janssens, Derek H, Henikoff, Jorja G, Feldman, Heather, Paddison, Patrick J, Lockwood, Christina M, Vitanza, Nicholas A, Olson, James M, Ahmad, Kami, Henikoff, Steven
Publicado 2020

Multi-level functional genomics reveals molecular and cellular oncogenicity of patient-based 3′ untranslated region mutations

por Schuster, Samantha L., Arora, Sonali, Wladyka, Cynthia L., Itagi, Pushpa, Corey, Lukas, Young, Dave, Stackhouse, Bethany L., Kollath, Lori, Wu, Qian V., Corey, Eva, True, Lawrence D., Ha, Gavin, Paddison, Patrick J., Hsieh, Andrew C.
Publicado 2023

Comparison of tumor-associated YAP1 fusions identifies a recurrent set of functions critical for oncogenesis

por Szulzewsky, Frank, Arora, Sonali, Hoellerbauer, Pia, King, Claire, Nathan, Erica, Chan, Marina, Cimino, Patrick J., Ozawa, Tatsuya, Kawauchi, Daisuke, Pajtler, Kristian W., Gilbertson, Richard J., Paddison, Patrick J., Vasioukhin, Valeri, Gujral, Taranjit S., Holland, Eric C.
Publicado 2020

N(6)-methyladenosine mRNA marking promotes selective translation of regulons required for human erythropoiesis

por Kuppers, Daniel A., Arora, Sonali, Lim, Yiting, Lim, Andrea R., Carter, Lucas M., Corrin, Philip D., Plaisier, Christopher L., Basom, Ryan, Delrow, Jeffrey J., Wang, Shiyan, Hansen He, Housheng, Torok-Storb, Beverly, Hsieh, Andrew C., Paddison, Patrick J.
Publicado 2019

In vivo RNAi screen identifies NLK as a negative regulator of mesenchymal activity in glioblastoma

por Sa, Jason K., Yoon, Yeup, Kim, Misuk, Kim, Yeonghwan, Cho, Hee Jin, Lee, Jin-Ku, Kim, Gi-Soo, Han, Suji, Kim, Woon Jin, Shin, Yong Jae, Joo, Kyeung Min, Paddison, Patrick J., Ishitani, Tohru, Lee, Jeongwu, Nam, Do-Hyun
Publicado 2015

A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways

por Pattwell, Siobhan S., Arora, Sonali, Cimino, Patrick J., Ozawa, Tatsuya, Szulzewsky, Frank, Hoellerbauer, Pia, Bonifert, Tobias, Hoffstrom, Benjamin G., Boiani, Norman E., Bolouri, Hamid, Correnti, Colin E., Oldrini, Barbara, Silber, John R., Squatrito, Massimo, Paddison, Patrick J., Holland, Eric C.
Publicado 2020

Functional genomic analysis of adult and pediatric brain tumor isolates

por Hoellerbauer, Pia, Biery, Matt C., Arora, Sonali, Rao, Yiyun, Girard, Emily J., Mitchell, Kelly, Dighe, Pratiksha, Kufeld, Megan, Kuppers, Daniel A., Herman, Jacob A., Holland, Eric C., Soroceanu, Liliana, Vitanza, Nicholas A., Olson, James M., Pritchard, Justin R., Paddison, Patrick J.
Publicado 2023

PIP4K2A as a negative regulator of PI3K in PTEN-deficient glioblastoma

por Shin, Yong Jae, Sa, Jason K., Lee, Yeri, Kim, Donggeon, Chang, Nakho, Cho, Hee Jin, Son, Miseol, Oh, Michael Y.T., Shin, Kayoung, Lee, Jin-Ku, Park, Jiwon, Jo, Yoon Kyung, Kim, Misuk, Paddison, Patrick J., Tergaonkar, Vinay, Lee, Jeongwu, Nam, Do-Hyun
Publicado 2019

Neural G0: a quiescent‐like state found in neuroepithelial‐derived cells and glioma

por O’Connor, Samantha A, Feldman, Heather M, Arora, Sonali, Hoellerbauer, Pia, Toledo, Chad M, Corrin, Philip, Carter, Lucas, Kufeld, Megan, Bolouri, Hamid, Basom, Ryan, Delrow, Jeffrey, McFaline‐Figueroa, José L, Trapnell, Cole, Pollard, Steven M, Patel, Anoop, Paddison, Patrick J, Plaisier, Christopher L
Publicado 2021