High-resolution crystal structure of arthropod Eiger TNF suggests a mode of receptor engagement and altered surface charge within endosomes

por Bertinelli, Mattia, Paesen, Guido C., Grimes, Jonathan M., Renner, Max
Publicado 2019

Structural Insights into the Human Metapneumovirus Glycoprotein Ectodomain

por Leyrat, Cedric, Paesen, Guido C., Charleston, James, Renner, Max, Grimes, Jonathan M.
Publicado 2014

Recent Advances in Bunyavirus Glycoprotein Research: Precursor Processing, Receptor Binding and Structure

por Hulswit, Ruben J. G., Paesen, Guido C., Bowden, Thomas A., Shi, Xiaohong
Publicado 2021

Comparison of Entropic Contributions to Binding in a “Hydrophilic” versus “Hydrophobic” Ligand−Protein Interaction

por Syme, Neil R., Dennis, Caitriona, Bronowska, Agnieszka, Paesen, Guido C., Homans, Steve W.
Publicado 2010

Structural dissection of human metapneumovirus phosphoprotein using small angle x-ray scattering

por Renner, Max, Paesen, Guido C., Grison, Claire M., Granier, Sébastien, Grimes, Jonathan M., Leyrat, Cédric
Publicado 2017

Insights from the crystal structure of the chicken CREB3 bZIP suggest that members of the CREB3 subfamily transcription factors may be activated in response to oxidative stress

por Sabaratnam, Keshalini, Renner, Max, Paesen, Guido, Harlos, Karl, Nair, Venugopal, Owens, Raymond J., Grimes, Jonathan M.
Publicado 2019

X-ray structure and activities of an essential Mononegavirales L-protein domain

por Paesen, Guido C., Collet, Axelle, Sallamand, Corinne, Debart, Françoise, Vasseur, Jean-Jacques, Canard, Bruno, Decroly, Etienne, Grimes, Jonathan M.
Publicado 2015

Nucleocapsid assembly in pneumoviruses is regulated by conformational switching of the N protein

por Renner, Max, Bertinelli, Mattia, Leyrat, Cédric, Paesen, Guido C, Saraiva de Oliveira, Laura Freitas, Huiskonen, Juha T, Grimes, Jonathan M
Publicado 2016

The Structure of OMCI, a Novel Lipocalin Inhibitor of the Complement System

por Roversi, Pietro, Lissina, Olga, Johnson, Steven, Ahmat, Nurfilza, Paesen, Guido C., Ploss, Kerstin, Boland, Wilhelm, Nunn, Miles A., Lea, Susan M.
Publicado 2007

The methyltransferase domain of the Sudan ebolavirus L protein specifically targets internal adenosines of RNA substrates, in addition to the cap structure

por Martin, Baptiste, Coutard, Bruno, Guez, Théo, Paesen, Guido C, Canard, Bruno, Debart, Françoise, Vasseur, Jean-Jacques, Grimes, Jonathan M, Decroly, Etienne
Publicado 2018

Structural basis of cholesterol binding by a novel clade of dendritic cell modulators from ticks

por Roversi, Pietro, Johnson, Steven, Preston, Stephen G., Nunn, Miles A., Paesen, Guido C., Austyn, Jonathan M., Nuttall, Patricia A., Lea, Susan M.
Publicado 2017

Contrasting Modes of New World Arenavirus Neutralization by Immunization-Elicited Monoclonal Antibodies

por Ng, Weng M., Sahin, Mehmet, Krumm, Stefanie A., Seow, Jeffrey, Zeltina, Antra, Harlos, Karl, Paesen, Guido C., Pinschewer, Daniel D., Doores, Katie J., Bowden, Thomas A.
Publicado 2022

Novel Immunomodulators from Hard Ticks Selectively Reprogramme Human Dendritic Cell Responses

por Preston, Stephen G., Majtán, Juraj, Kouremenou, Chrisoula, Rysnik, Oliwia, Burger, Lena F., Cabezas Cruz, Alejandro, Chiong Guzman, Maylin, Nunn, Miles A., Paesen, Guido C., Nuttall, Patricia A., Austyn, Jonathan M.
Publicado 2013

Bifunctional Lipocalin Ameliorates Murine Immune Complex-induced Acute Lung Injury

por Roversi, Pietro, Ryffel, Bernhard, Togbe, Dieudonnée, Maillet, Isabelle, Teixeira, Mauro, Ahmat, Nurfilza, Paesen, Guido C., Lissina, Olga, Boland, Wilhelm, Ploss, Kerstin, Caesar, Joseph J. E., Leonhartsberger, Susanne, Lea, Susan M., Nunn, Miles A.
Publicado 2013

Molecular rationale for antibody-mediated targeting of the hantavirus fusion glycoprotein

por Rissanen, Ilona, Stass, Robert, Krumm, Stefanie A, Seow, Jeffrey, Hulswit, Ruben JG, Paesen, Guido C, Hepojoki, Jussi, Vapalahti, Olli, Lundkvist, Åke, Reynard, Olivier, Volchkov, Viktor, Doores, Katie J, Huiskonen, Juha T, Bowden, Thomas A
Publicado 2020

Multifunctional human monoclonal antibody combination mediates protection against Rift Valley fever virus at low doses

por Chapman, Nathaniel S., Hulswit, Ruben J. G., Westover, Jonna L. B., Stass, Robert, Paesen, Guido C., Binshtein, Elad, Reidy, Joseph X., Engdahl, Taylor B., Handal, Laura S., Flores, Alejandra, Gowen, Brian B., Bowden, Thomas A., Crowe, James E.
Publicado 2023

VelcroVax: a “Bolt-On” Vaccine Platform for Glycoprotein Display

por Kingston, Natalie J., Grehan, Keith, Snowden, Joseph S., Hassall, Mark, Alzahrani, Jehad, Paesen, Guido C., Sherry, Lee, Hayward, Connor, Roe, Amy, Stephen, Sam, Tomlinson, Darren, Zeltina, Antra, Doores, Katie J., Ranson, Neil A., Stacey, Martin, Page, Mark, Rose, Nicola J., Bowden, Thomas A., Rowlands, David J., Stonehouse, Nicola J.
Publicado 2023

Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera

por Zhou, Daming, Dejnirattisai, Wanwisa, Supasa, Piyada, Liu, Chang, Mentzer, Alexander J., Ginn, Helen M., Zhao, Yuguang, Duyvesteyn, Helen M.E., Tuekprakhon, Aekkachai, Nutalai, Rungtiwa, Wang, Beibei, Paesen, Guido C., Lopez-Camacho, Cesar, Slon-Campos, Jose, Hallis, Bassam, Coombes, Naomi, Bewley, Kevin, Charlton, Sue, Walter, Thomas S., Skelly, Donal, Lumley, Sheila F., Dold, Christina, Levin, Robert, Dong, Tao, Pollard, Andrew J., Knight, Julian C., Crook, Derrick, Lambe, Teresa, Clutterbuck, Elizabeth, Bibi, Sagida, Flaxman, Amy, Bittaye, Mustapha, Belij-Rammerstorfer, Sandra, Gilbert, Sarah, James, William, Carroll, Miles W., Klenerman, Paul, Barnes, Eleanor, Dunachie, Susanna J., Fry, Elizabeth E., Mongkolsapaya, Juthathip, Ren, Jingshan, Stuart, David I., Screaton, Gavin R.
Publicado 2021

Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera

por Supasa, Piyada, Zhou, Daming, Dejnirattisai, Wanwisa, Liu, Chang, Mentzer, Alexander J., Ginn, Helen M., Zhao, Yuguang, Duyvesteyn, Helen M.E., Nutalai, Rungtiwa, Tuekprakhon, Aekkachai, Wang, Beibei, Paesen, Guido C., Slon-Campos, Jose, López-Camacho, César, Hallis, Bassam, Coombes, Naomi, Bewley, Kevin R., Charlton, Sue, Walter, Thomas S., Barnes, Eleanor, Dunachie, Susanna J., Skelly, Donal, Lumley, Sheila F., Baker, Natalie, Shaik, Imam, Humphries, Holly E., Godwin, Kerry, Gent, Nick, Sienkiewicz, Alex, Dold, Christina, Levin, Robert, Dong, Tao, Pollard, Andrew J., Knight, Julian C., Klenerman, Paul, Crook, Derrick, Lambe, Teresa, Clutterbuck, Elizabeth, Bibi, Sagida, Flaxman, Amy, Bittaye, Mustapha, Belij-Rammerstorfer, Sandra, Gilbert, Sarah, Hall, David R., Williams, Mark A., Paterson, Neil G., James, William, Carroll, Miles W., Fry, Elizabeth E., Mongkolsapaya, Juthathip, Ren, Jingshan, Stuart, David I., Screaton, Gavin R.
Publicado 2021

The antigenic anatomy of SARS-CoV-2 receptor binding domain

por Dejnirattisai, Wanwisa, Zhou, Daming, Ginn, Helen M., Duyvesteyn, Helen M.E., Supasa, Piyada, Case, James Brett, Zhao, Yuguang, Walter, Thomas S., Mentzer, Alexander J., Liu, Chang, Wang, Beibei, Paesen, Guido C., Slon-Campos, Jose, López-Camacho, César, Kafai, Natasha M., Bailey, Adam L., Chen, Rita E., Ying, Baoling, Thompson, Craig, Bolton, Jai, Fyfe, Alex, Gupta, Sunetra, Tan, Tiong Kit, Gilbert-Jaramillo, Javier, James, William, Knight, Michael, Carroll, Miles W., Skelly, Donal, Dold, Christina, Peng, Yanchun, Levin, Robert, Dong, Tao, Pollard, Andrew J., Knight, Julian C., Klenerman, Paul, Temperton, Nigel, Hall, David R., Williams, Mark A., Paterson, Neil G., Bertram, Felicity K.R., Siebert, C. Alistair, Clare, Daniel K., Howe, Andrew, Radecke, Julika, Song, Yun, Townsend, Alain R., Huang, Kuan-Ying A., Fry, Elizabeth E., Mongkolsapaya, Juthathip, Diamond, Michael S., Ren, Jingshan, Stuart, David I., Screaton, Gavin R.
Publicado 2021