Comparison of Pharmacokinetics of the GalNAc-Conjugated Antisense Oligonucleotide GSK3389404 in Participants with Chronic Hepatitis B Infection across the Asia-Pacific Region

por Han, Kelong, Ito, Hiroshi, Elston, Robert, Cremer, Jennifer, Hood, Steve, Paff, Melanie, Theodore, Dickens
Publicado 2022

B-Clear Phase 2b Study Design: Establishing the Efficacy and Safety of Bepirovirsen in Patients with Chronic Hepatitis B Virus Infection

por Cremer, Jennifer, Elston, Robert, Campbell, Fiona M., Kendrick, Stuart, Paff, Melanie, Quinn, Geoff, Theodore, Dickens
Publicado 2023

Safety, Tolerability, Pharmacokinetics, and Acceptability of Oral and Long-Acting Cabotegravir in HIV-Negative Chinese Men

por Han, Kelong, Wannamaker, Paul, Lu, Hongzhou, Zhu, Biao, Wang, Meixia, Paff, Melanie, Spreen, William R., Ford, Susan L.
Publicado 2022

Preclinical and Phase 1 Assessment of Antisense Oligonucleotide Bepirovirsen in Hepatitis B Virus–Transgenic Mice and Healthy Human Volunteers: Support for Clinical Dose Selection...

por Han, Kelong, Theodore, Dickens, McMullen, Gina, Swayze, Eric, McCaleb, Michael, Billioud, Gaetan, Wieland, Stefan, Hood, Steve, Paff, Melanie, Bennett, C. Frank, Kwoh, T. Jesse
Publicado 2022

A Randomized, Double‐Blind, Placebo‐Controlled, First‐Time‐in‐Human Study to Assess the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of GSK3389...

por Han, Kelong, Cremer, Jennifer, Elston, Robert, Oliver, Stuart, Baptiste‐Brown, Sharon, Chen, Shuguang, Gardiner, David, Davies, Matt, Saunders, Joanne, Hamatake, Robert, Losos, Jan, Leivers, Martin, Hood, Steve, van der Berg, Frans, Paff, Melanie, Ritter, James M., Theodore, Dickens
Publicado 2019

Safety, tolerability and antiviral activity of the antisense oligonucleotide bepirovirsen in patients with chronic hepatitis B: a phase 2 randomized controlled trial

por Yuen, Man-Fung, Heo, Jeong, Jang, Jeong-Won, Yoon, Jung-Hwan, Kweon, Young-Oh, Park, Sung-Jae, Tami, Yvonne, You, Shihyun, Yates, Phillip, Tao, Yu, Cremer, Jennifer, Campbell, Fiona, Elston, Robert, Theodore, Dickens, Paff, Melanie, Bennett, C. Frank, Kwoh, T. Jesse
Publicado 2021