The Hen or the Egg: Inflammatory Aspects of Murine MPN Models

por Jutzi, Jonas S., Pahl, Heike L.
Publicado 2015

The Cross Marks the Spot: The Emerging Role of JmjC Domain-Containing Proteins in Myeloid Malignancies

por Staehle, Hans Felix, Pahl, Heike Luise, Jutzi, Jonas Samuel
Publicado 2021

Pharmacological Inhibition of Insulin Growth Factor-1 Receptor (IGF-1R) Alone or in Combination With Ruxolitinib Shows Therapeutic Efficacy in Preclinical Myeloproliferative Neopla...

por Basu, Titiksha, Bertrand, Hannah, Karantzelis, Nikolaos, Gründer, Albert, Pahl, Heike L.
Publicado 2021

Water pipe smoking as a cause of secondary erythrocytosis

por Javorniczky, Nora Rebeka, Waller, Cornelius F, Pahl, Heike L, von Bubnoff, Nikolas, Becker, Heiko
Publicado 2019

Jmjd1c is dispensable for healthy adult hematopoiesis and Jak2(V617F)-driven myeloproliferative disease initiation in mice

por Staehle, Hans F., Heinemann, Johannes, Gruender, Albert, Omlor, Anne M., Pahl, Heike Luise, Jutzi, Jonas Samuel
Publicado 2020

Concomitant constitutive LNK and NFE2 mutation with loss of sumoylation in a case of hereditary thrombocythemia

por Böckelmann, Lukas Clemens, Basu, Titiksha, Gründer, Albert, Wang, Wei, Breucker, Jan, Kaiser, Sandra, Pichler, Andrea, Pahl, Heike Luise
Publicado 2021

Gab2 is Essential for Transformation by FLT3-ITD in Acute Myeloid Leukemia

por Sies, Katharina, Spohr, Corinna, Gründer, Albert, Todorova, Rumyana, Uhl, Franziska Maria, Huber, Julia, Zeiser, Robert, Pahl, Heike Luise, Becker, Heiko, Aumann, Konrad, Brummer, Tilman, Halbach, Sebastian
Publicado 2019

Haematopoietic stem cell survival and transplantation efficacy is limited by the BH3-only proteins Bim and Bmf

por Labi, Verena, Bertele, Daniela, Woess, Claudia, Tischner, Denise, Bock, Florian J, Schwemmers, Sven, Pahl, Heike L, Geley, Stephan, Kunze, Mirjam, Niemeyer, Charlotte M, Villunger, Andreas, Erlacher, Miriam
Publicado 2013

The histone demethylase JMJD2C constitutes a novel NFE2 target gene that is required for the survival of JAK2(V617F) mutated cells

por Staehle, Anne Marie, Peeken, Jan Caspar, Vladimirov, Georg, Hoeness, Mirjam Elisabeth, Bojtine Kovacs, Sarolta, Karantzelis, Nikolaos, Gruender, Albert, Koellerer, Christoph, Jutzi, Jonas Samuel, Pahl, Heike Luise, Staehle, Hans Felix
Publicado 2023

LSD1 Inhibition Prolongs Survival in Mouse Models of MPN by Selectively Targeting the Disease Clone

por Jutzi, Jonas S., Kleppe, Maria, Dias, Jennifer, Staehle, Hans Felix, Shank, Kaitlyn, Teruya-Feldstein, Julie, Gambheer, Sudheer Madan Mohan, Dierks, Christine, Rienhoff, Hugh Y., Levine, Ross L., Pahl, Heike L.
Publicado 2018

Ptch2 loss drives myeloproliferation and myeloproliferative neoplasm progression

por Klein, Claudius, Zwick, Anabel, Kissel, Sandra, Forster, Christine Ulrike, Pfeifer, Dietmar, Follo, Marie, Illert, Anna Lena, Decker, Sarah, Benkler, Thomas, Pahl, Heike, Oostendorp, Robert A.J., Aumann, Konrad, Duyster, Justus, Dierks, Christine
Publicado 2016

Real-world analysis of ruxolitinib in myelofibrosis: interim results focusing on patients who were naïve to JAK inhibitor therapy treated within the JAKoMo non-interventional, phas...

por Koschmieder, Steffen, Isfort, Susanne, Schulte, Clemens, Jacobasch, Lutz, Geer, Thomas, Reiser, Marcel, Koenigsmann, Michael, Heinrich, Bernhard, Wehmeyer, Jürgen, von der Heyde, Eyck, Tesch, Hans, Gröschl, Benedikt, Bachhuber, Petra, Großer, Susanne, Pahl, Heike L.
Publicado 2023

MPN patients harbor recurrent truncating mutations in transcription factor NF-E2

por Jutzi, Jonas S., Bogeska, Ruzhica, Nikoloski, Gorica, Schmid, Corina A., Seeger, Thalia S., Stegelmann, Frank, Schwemmers, Sven, Gründer, Albert, Peeken, Jan C., Gothwal, Monika, Wehrle, Julius, Aumann, Konrad, Hamdi, Kamar, Dierks, Christine, Wang, Wei, Döhner, Konstanze, Jansen, Joop H., Pahl, Heike L.
Publicado 2013

New C3H Kit(N824K/WT) cancer mouse model develops late-onset malignant mammary tumors with high penetrance

por Klein-Rodewald, Tanja, Micklich, Kateryna, Sanz-Moreno, Adrián, Tost, Monica, Calzada-Wack, Julia, Adler, Thure, Klaften, Matthias, Sabrautzki, Sibylle, Aigner, Bernhard, Kraiger, Markus, Gailus-Durner, Valerie, Fuchs, Helmut, Gründer, Albert, Pahl, Heike, Wolf, Eckhard, Hrabe de Angelis, Martin, Rathkolb, Birgit
Publicado 2022

A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2

por Kaufmann, Kai B., Gründer, Albert, Hadlich, Tobias, Wehrle, Julius, Gothwal, Monika, Bogeska, Ruzhica, Seeger, Thalia S., Kayser, Sarah, Pham, Kien-Binh, Jutzi, Jonas S., Ganzenmüller, Lucas, Steinemann, Doris, Schlegelberger, Brigitte, Wagner, Julia M., Jung, Manfred, Will, Britta, Steidl, Ulrich, Aumann, Konrad, Werner, Martin, Günther, Thomas, Schüle, Roland, Rambaldi, Alessandro, Pahl, Heike L.
Publicado 2012

Kidney Dysfunction Is Associated with Thrombosis and Disease Severity in Myeloproliferative Neoplasms: Implications from the German Study Group for MPN Bioregistry

por Gecht, Judith, Tsoukakis, Ioannis, Kricheldorf, Kim, Stegelmann, Frank, Klausmann, Martine, Griesshammer, Martin, Schulz, Holger, Hollburg, Wiebke, Göthert, Joachim R., Sockel, Katja, Heidel, Florian H., Gattermann, Norbert, Maintz, Christoph, Al-Ali, Haifa K., Platzbecker, Uwe, Hansen, Richard, Hänel, Mathias, Parmentier, Stefani, Bommer, Martin, Pahl, Heike L., Lang, Fabian, Kirschner, Martin, Isfort, Susanne, Brümmendorf, Tim H., Döhner, Konstanze, Koschmieder, Steffen
Publicado 2021